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As we know finasteride is a progestin with an ability to bind to progesterone and cortisol receptor
Basically making cortisol and progesterone receptors not sensitive after you quit the drug in once case and may be making them too sensitive in another.
As we know cortisol reception at the DNA level is with zinc finger. Without zinc finger cortisol simply does not work. and body keeps it high in blood .
This circulating high cortisol binds to aldo receptor and causes magnesium loss plus potassium loss. Thus we see progesterone high also and inability of the body to raise potassium thus low metabolism and alkalosis with either volume reduction or volume expanstion.( depending on PSSD, PFS) When you crash from FIN, you crash hard and you have very low metabolism. Since you cant retain potassium.
When there is no potassium and low metabolism copper becomes biounavaible this causes the hairloss. that is why there are quite a few patents of using CU HIS along with glycine. Since those are the base aminos, and problematic to digest in alkalosis states.
Patent US5177061 - Method for stimulating hair growth using GHL-Cu complexes Example of a patent.
Another study used histidine copper zinc cysteine for hair
For libido several studies used FOLATE plus histidine.
Histidine deficiency causes FOLATE deficiency. And folate deficiency causes histidine to be lost in the urine.
The role of histidine in the anemia of folate deficiency. | PubFacts.com
There are many studies showing histidine deficiency in MS, Parkinsons http://www.chiro.org/research/ABSTRACTS/Transdermal_Histamine_2.pdf
This is test some guy did with chronic fatique syndrome. My Theory - Histidine Depletion
SO basically people could find the missing link in their zinc finger and lower cortisol this way. For some it will be zinc, for some it will be histidine or its precursors, and for some it will be cysteine and its precursors. For some people they will be low in copper and high in zinc and low in histidine. If they take copper they feel bad. since cortisol goes up and causes hypokalemia. Thus they can take histidine with copper and feel fine.
Now I guess fin can downregulate this zinc finger or upregulate it. And this is why the body can't snap out of it. And also cortisol in the body does not work. It is high but is not working.
Zinc finger is zinc with cysteine, and histidine. For cysteine you need b6 ,plus magnesium plus serine. and methylation. For histidine you need phospforus and b2 and nad. For histidine is not that easy , there is a pathway in the body to synthesis it, but it requires 8 reactions with TONS OF atp, B2 , b3,folate, phosphorus, all the limiting things in usually sick individual.
Histidine is in hemoglboin, it is in CDO which converts cysteine, it is needed for histamine, without which there is no stomach acid. It is needed for nerv conductivity without that you dont have brain organ connection. It is part of insulin with zinc. That is why when there is no zinc finger and insensitive cortisol , it obviously lowers your insulin level, which we can see quit a bit in PFS. Also it is a part of SOD which a lot of people target for hairloss along with copper
Plus histidine along with lysine and arginine are base aminos. that is why always supplied with HCL.
I think fin downregulated or downregulated these systems and body cant get them back in , since it is stuck in low metabolism.
The downregulation could be caused by tanking potassium which made chloride biounvailable basically stopping stomach acid.
With that all your alkaline amino acids are not absorbed.
I think originally this zinc finger was also not working. And thus cortisol was raised and metabolism was down. this is why fin was invented to force the cortisol and progesterone.
Hairloss is basically cortisol insensitivity. Which causes high cortisol. And aldo binding and hypokalemia and then low thyroid effect.
Your coritsol is basically low you are very deficient in it. But unfortunately it does not work, and binds to aldo receptors causing harm by lowering potassium. If you make this cortisol sensitive, the actual level of it will fall, but its action will be high, this will not bind to aldosterone and will not cause hypokalemia. And this sensitive cortisol will allow your thyroid to go up in the cell.
So basically if you miss this zinc finger, your cortisol will be raised , and it will cause your metabolism to crash. And at the same time, you will be severely deficient in cortisol actions as antiinflammatory , since it simply does not work, but it is high.
Zinc finger is cysteine, histidine , and zinc. Just look for pathways how those amino acids are made. Those will be the nutrients to fight the hairloss and to lower cortisol BY MAKING IT MORE SENSITIVE
I found one study that tried to use histidine copper zinc cysteine for hairloss. With amazing results.
Also I think that is WHY RU worked with progesterone better. RU blocked cortisol, this probably upregulated zinc finger.
And at the same time you take progesterone with cofactors.
So to finish this up, may be we can try to increase zinc finger, with magnesium b6, b2, b3, Fоlate, phosphorus, histidine, cysteine. selenium And at the same time feed potassium and may be some copper. And do something for phosphorus
T
Just a theory of how to deal with it on the receptors and mineral levels. Worth a try I think
Welcome some discussion and may be we can find a correct protocol.
IIMPORTANT. Also I would assume there will be the case of exact opposite if fin upregulated the zinc finger. In this case I would assume dexamethasone or progesterone will help.
WE need not to jump into this protocol, but discuss it first. And see which case we are.
This is basically the same protocol as I outlined originally for 2 cases, but with more details as to cortisol and progesterone receptors. And don't forget it is all theory for now. So we need to try 2 routes here, to upregulate zinc finger or downregulate it.
To downregulate I would assume we can use dexamethasone , progesterone. To upregulate we can use us the scheme above.
I guess for some one case will be for hairloss, and another case will be for PFS
All these cases are outlined in original PFS thread. I just started this new discussion so we can may be accent this zinc finger here.
It is about fixing the alkalosis that was caused and fixing digestion:
Chronic stress, metal toxicities, computer work( blue light), vaccines, drinking tons of milk can decrease your zinc finger. This will keep CORTISOL HIGH, since it is not working well. This cortisol usually binds to aldo receptors and causes hypokalemia and hypomagnemia. Also there is a possibility of chloride loss from vomitting and antacids. This causes LOW STOMACH ACID
due to loss of the electrolytes. Because of this you don't digest protein correctly and also your systemic protein is very low. You have lactic acidosis, with problems with hemoglobin, insulin etc.
Cortisol is raised in all these conditions since body is missing zinc finger . Cysteine can actually be high , since histidine is missing and not able to convert it further to glutathione and taurine pathway. Cortisol is high , but not sensitive, in most cases it causes hypokalemia, which mimics low thyroid effect. IT HAS NOTHING TO DO with your thyroid. You are not hypo thyroid, and never take any hormones. Thyroid is totally fine, when you upregulate your zinc finger, cortisol will work and will activate all copper enzymes and cortisol will increases protein synthesis and the actual level of cortisol will fall. Insensitive cortisol causes lack of protein and connective tissue, NOT THE OPPOSITE. CORTISOL ACTIVATES PROTEIN SYNTHESIS and puts ZINC IN THE CELL TO DO SO. It activates collagen synthesis. When cortisol is high, means body is trying to make more of it,since it is not working good enough.
This is why when you are fasting your protein synthesis is even better and the body is creating new tissue at better speed and of a better quality. So please stop listening to people saying cortisol is evil . THEY ARE TOTALLY ABSOLUTELY WRONG. CORTISOL IS NOT WORKING , IT IS RAISED for a reason, And those who lower it, suffer from protein synthesis problems. They need to increase its reception and this will cause cortisol to lower without decreasing protein synthesis and zinc from the cell.
Cortisol is HIGH in the first alarm stage of stress, when zinc finger is missing, but slowly it gets lower and lower and lower and that is when you get into low cortisol and very slow oxidizer. Cortisol goes down with the development of the protein deficiency.
Diet
30% carbs, 50 protein, 20 fat. Vary this by increasing carbs with physical activity
Good carbs= rice
Good protein= sea food in form of shrimp, oysters, mussels, octopus , non fat fish, tuna is ok.
Plenty of vegetables( like Kale, spinach, etc) PUT HEAVY ACCENT ON SPINACH AND KALE and try to eat it with every meal.
Some fruit, not much. Apples , nectarines, all kinds of fruits that you like.
Milk wise, I recommend almond milk for calcium.
Once a year, 20 day fast Breuss style. And actually you can juice Breuss all this time.
THE SECOND CASE IS when zinc finger is raised and lets say you have high histidine. IN this case you probably have low folate and inability to break down histidine into glutamic acid.
Basically making cortisol and progesterone receptors not sensitive after you quit the drug in once case and may be making them too sensitive in another.
As we know cortisol reception at the DNA level is with zinc finger. Without zinc finger cortisol simply does not work. and body keeps it high in blood .
This circulating high cortisol binds to aldo receptor and causes magnesium loss plus potassium loss. Thus we see progesterone high also and inability of the body to raise potassium thus low metabolism and alkalosis with either volume reduction or volume expanstion.( depending on PSSD, PFS) When you crash from FIN, you crash hard and you have very low metabolism. Since you cant retain potassium.
When there is no potassium and low metabolism copper becomes biounavaible this causes the hairloss. that is why there are quite a few patents of using CU HIS along with glycine. Since those are the base aminos, and problematic to digest in alkalosis states.
Patent US5177061 - Method for stimulating hair growth using GHL-Cu complexes Example of a patent.
Another study used histidine copper zinc cysteine for hair
For libido several studies used FOLATE plus histidine.
Histidine deficiency causes FOLATE deficiency. And folate deficiency causes histidine to be lost in the urine.
The role of histidine in the anemia of folate deficiency. | PubFacts.com
There are many studies showing histidine deficiency in MS, Parkinsons http://www.chiro.org/research/ABSTRACTS/Transdermal_Histamine_2.pdf
This is test some guy did with chronic fatique syndrome. My Theory - Histidine Depletion
SO basically people could find the missing link in their zinc finger and lower cortisol this way. For some it will be zinc, for some it will be histidine or its precursors, and for some it will be cysteine and its precursors. For some people they will be low in copper and high in zinc and low in histidine. If they take copper they feel bad. since cortisol goes up and causes hypokalemia. Thus they can take histidine with copper and feel fine.
Now I guess fin can downregulate this zinc finger or upregulate it. And this is why the body can't snap out of it. And also cortisol in the body does not work. It is high but is not working.
Zinc finger is zinc with cysteine, and histidine. For cysteine you need b6 ,plus magnesium plus serine. and methylation. For histidine you need phospforus and b2 and nad. For histidine is not that easy , there is a pathway in the body to synthesis it, but it requires 8 reactions with TONS OF atp, B2 , b3,folate, phosphorus, all the limiting things in usually sick individual.
Histidine is in hemoglboin, it is in CDO which converts cysteine, it is needed for histamine, without which there is no stomach acid. It is needed for nerv conductivity without that you dont have brain organ connection. It is part of insulin with zinc. That is why when there is no zinc finger and insensitive cortisol , it obviously lowers your insulin level, which we can see quit a bit in PFS. Also it is a part of SOD which a lot of people target for hairloss along with copper
Plus histidine along with lysine and arginine are base aminos. that is why always supplied with HCL.
I think fin downregulated or downregulated these systems and body cant get them back in , since it is stuck in low metabolism.
The downregulation could be caused by tanking potassium which made chloride biounvailable basically stopping stomach acid.
With that all your alkaline amino acids are not absorbed.
I think originally this zinc finger was also not working. And thus cortisol was raised and metabolism was down. this is why fin was invented to force the cortisol and progesterone.
Hairloss is basically cortisol insensitivity. Which causes high cortisol. And aldo binding and hypokalemia and then low thyroid effect.
Your coritsol is basically low you are very deficient in it. But unfortunately it does not work, and binds to aldo receptors causing harm by lowering potassium. If you make this cortisol sensitive, the actual level of it will fall, but its action will be high, this will not bind to aldosterone and will not cause hypokalemia. And this sensitive cortisol will allow your thyroid to go up in the cell.
So basically if you miss this zinc finger, your cortisol will be raised , and it will cause your metabolism to crash. And at the same time, you will be severely deficient in cortisol actions as antiinflammatory , since it simply does not work, but it is high.
Zinc finger is cysteine, histidine , and zinc. Just look for pathways how those amino acids are made. Those will be the nutrients to fight the hairloss and to lower cortisol BY MAKING IT MORE SENSITIVE
I found one study that tried to use histidine copper zinc cysteine for hairloss. With amazing results.
Also I think that is WHY RU worked with progesterone better. RU blocked cortisol, this probably upregulated zinc finger.
And at the same time you take progesterone with cofactors.
So to finish this up, may be we can try to increase zinc finger, with magnesium b6, b2, b3, Fоlate, phosphorus, histidine, cysteine. selenium And at the same time feed potassium and may be some copper. And do something for phosphorus
T
Just a theory of how to deal with it on the receptors and mineral levels. Worth a try I think
Welcome some discussion and may be we can find a correct protocol.
IIMPORTANT. Also I would assume there will be the case of exact opposite if fin upregulated the zinc finger. In this case I would assume dexamethasone or progesterone will help.
WE need not to jump into this protocol, but discuss it first. And see which case we are.
This is basically the same protocol as I outlined originally for 2 cases, but with more details as to cortisol and progesterone receptors. And don't forget it is all theory for now. So we need to try 2 routes here, to upregulate zinc finger or downregulate it.
To downregulate I would assume we can use dexamethasone , progesterone. To upregulate we can use us the scheme above.
I guess for some one case will be for hairloss, and another case will be for PFS
All these cases are outlined in original PFS thread. I just started this new discussion so we can may be accent this zinc finger here.
It is about fixing the alkalosis that was caused and fixing digestion:
Chronic stress, metal toxicities, computer work( blue light), vaccines, drinking tons of milk can decrease your zinc finger. This will keep CORTISOL HIGH, since it is not working well. This cortisol usually binds to aldo receptors and causes hypokalemia and hypomagnemia. Also there is a possibility of chloride loss from vomitting and antacids. This causes LOW STOMACH ACID
due to loss of the electrolytes. Because of this you don't digest protein correctly and also your systemic protein is very low. You have lactic acidosis, with problems with hemoglobin, insulin etc.
Cortisol is raised in all these conditions since body is missing zinc finger . Cysteine can actually be high , since histidine is missing and not able to convert it further to glutathione and taurine pathway. Cortisol is high , but not sensitive, in most cases it causes hypokalemia, which mimics low thyroid effect. IT HAS NOTHING TO DO with your thyroid. You are not hypo thyroid, and never take any hormones. Thyroid is totally fine, when you upregulate your zinc finger, cortisol will work and will activate all copper enzymes and cortisol will increases protein synthesis and the actual level of cortisol will fall. Insensitive cortisol causes lack of protein and connective tissue, NOT THE OPPOSITE. CORTISOL ACTIVATES PROTEIN SYNTHESIS and puts ZINC IN THE CELL TO DO SO. It activates collagen synthesis. When cortisol is high, means body is trying to make more of it,since it is not working good enough.
This is why when you are fasting your protein synthesis is even better and the body is creating new tissue at better speed and of a better quality. So please stop listening to people saying cortisol is evil . THEY ARE TOTALLY ABSOLUTELY WRONG. CORTISOL IS NOT WORKING , IT IS RAISED for a reason, And those who lower it, suffer from protein synthesis problems. They need to increase its reception and this will cause cortisol to lower without decreasing protein synthesis and zinc from the cell.
Cortisol is HIGH in the first alarm stage of stress, when zinc finger is missing, but slowly it gets lower and lower and lower and that is when you get into low cortisol and very slow oxidizer. Cortisol goes down with the development of the protein deficiency.
Diet
30% carbs, 50 protein, 20 fat. Vary this by increasing carbs with physical activity
Good carbs= rice
Good protein= sea food in form of shrimp, oysters, mussels, octopus , non fat fish, tuna is ok.
Plenty of vegetables( like Kale, spinach, etc) PUT HEAVY ACCENT ON SPINACH AND KALE and try to eat it with every meal.
Some fruit, not much. Apples , nectarines, all kinds of fruits that you like.
Milk wise, I recommend almond milk for calcium.
Once a year, 20 day fast Breuss style. And actually you can juice Breuss all this time.
THE SECOND CASE IS when zinc finger is raised and lets say you have high histidine. IN this case you probably have low folate and inability to break down histidine into glutamic acid.
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