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The way we determine what theories are accurate is to test the model predictions against real world data. For example, can I tell TEI a patient's ACTH level, and TEI calculates what the patient's cortisol level will be? If TEI has a supercomputer simulation, they should be able to do this. Then...

TEI definitely does something to the HPA axis, but the science of mineral balances does not go as in depth as these mathematical models of the HPA axis and related neuroendocrinology. So it could help, but it is not based on the current leading science. Additionally, since no one really knows...

There is a delay between ACTH release and cortisol release from the adrenal glands. Low cortisol can blunt its own production via negative feedback to the pituitary gland if the pituitary GR receptors are upregulated. For ex, ACTH starts to rise due to upstream stress response, cortisol starts...

PFS may induce some kind of insulin resistance. So rather than shuttling glucose out of your blood (which came from carbs you ate), your body just lets it hang around at high levels, making you feel shitty. You can try pharmacological routes like metformin or berberine to enhance insulin. Some...

For PSSD that involves HPA axis dysfunction, you should check cortisol levels. Get AM and PM cortisol blood tests, as well as ACTH. TEI sometimes gives you adrenal gland extract in their supplements, which contains cortisol. So stay off that for a few days before getting cortisol blood tests...

I think what is important here is NMDA/glutamate. Some PSSD types may be related to dysfunction of the hypothalmus. This would explain HPA axis issues we see in some people, like myself with low cortisol. A hypoactive hypothalmus reduces glutamate firing in general. What we should try to do is...

Some studies relevant to GABA: Low dose fluoxetine reverses decrease in allopreg caused by exogenous T. High androgens may downregulate 5aR and 3aHSOR enzymes, reducing allo and thus downregulating GABA-A. Fluoxetine can increase allo content at a low dose that does not cause serotonin reuptake...

A few people did try cypro on PSSDForum and felt better for a few days after taking it. It seems like a low dose (~1mg) is best, and to also support acetylcholine and dopamine while on it. 5HT1A receptors could also be involved as it appears they regulate cortisol as well. Cypro might also...

This could mean, people with overexpressed GR are having their adrenal androgens suppressed as it is over sensitive to cortisol. This suggests that reducing AR activation, like what happens when you reduce DHT with fin, could increase GR expression. I'm reminded of the guy on PropeciaHelp...

They say in the paper that a2 agonists release BDNF. This has been a subject of interest recently on the PSSD forum, and might explain recoveries with psychedelics. It also appears there is a link between GR activation and GABAA. For people like me with low cortisol, we could have hyper...

@Helen interesting. I eat a fair amount of spinach and greens, but I'll add K2 to the list of things to try soon. @Shanks I took around 3x 25mg (before meals) for 3 weeks. I've been off it for a few days now and havent noticed anything different from how I already was.

Been a while since my last update. Some interesting things are happening. I moved to a new state so I have been really busy with life, but still experimenting with things of course. My anhedonia has been better in the last two months. I attribute this to Profrontal (2g Sarcosine + 2g NAC)...

I've had good results with Profrontal (Sarcosine + NAC) for anhedonia. This combo supposedly enhances NMDA signaling. I dont have anywhere near as bad of symptoms as you but if you suspect NDMA then it's worth a shot, IMO. It took a little over a month for me to notice improvements.

This recent study on rat PSSD found low tyrosine hydroxylase, thus reduced dopamine synthesis from tyrosine. Some people have improved on mucuna puriens/L- DOPA, so there is both theoretical and experimental support for dopamine supplementation. I plan to try mucuna puriens soon, but the trick...

I have them, but have not tried yet since I'm currently trialing some other stuff. Will probably give them a short run in a few weeks though.

Zadig you are standing on the shoulders of giants. You only found out about thyroid+hc etc because others posted their experiences with them. It is selfish of you to benefit from other's experiences, but not post your own. We are all in this together, and need all the data we can get...

Why not use nicotinamide which doesnt cause flushing like other forms of b3? I took 2g the other day and didnt notice anything.

After looking over my old blood tests, I became curious of my thyroid function, as I had some nearly out of range results. So I checked my thyroid hormones. It looks like I'm almost in hypothyroid territory. Some docs would say a TSH over 2 can be hypothyroidic, although this is controversial...

@zadig777 bro you need to have a little more patience. Most of the cured stores take place over weeks or months, often with no improvements in the first few weeks. If something is going to help you, chances are you're not gunna know until you take it for at least a few weeks.

Damn that is one cold muthafucka