For the past few months, the user gbolduev has been discussing his theory on PFS over at the Ray Peat forum. Due to issues with moderation we thought it’d be best if the discussion was moved over here. This theory might also apply to other syndromes such as PSSD and post-Accutane, so stay tuned if you suffer from those.
Gbolduev has stated that drugs like finasteride act as a progestin in the body; meaning, they bind to progesterone receptors. This has many downstream effects, most notably on 3BHSD and many other enzymes (5ar), hormones (estradiol, cortisol, DHT), and minerals (potassium). Eventually, the body gets thrown into a chronic state of imbalance from which it is hard to recover.
The thought is that some people suffer from agonized prog receptors, while others suffer from antagonized receptors. Here are a few treatment protocols that were suggested for each case:
Case #1 – agonized receptors
1) Progesterone 50-400mg ED for 1 week w/ calorie restriction; then start on zinc + NAD
2) Magnesium 1000mg + B6 100-200mg + NAD 2000mg + zinc 100-200mg
3) Methylation using Thorne Multi-Vitamin Elite
4) Thyroid hormone + zinc + NAD
Case #2 – antagonized receptors
1) Copper 10mg ED; after 3 weeks add in zinc + NAD + magnesium + manganese + B6
2) High-dose manganese + co-factors
3) Estradiol + DHT
4) Andro + relora + licorice root
5) Pine pollen + relora + licorice root
6) Pine pollen + relora + nettle
There are ongoing trials with RU486 taking place. Others have tried fasting, methylation, pine pollen, and Ella (another anti-progestin) with good results. If you are unsure of which “case” you might fit into or have any questions in general, please post here. There are many people willing to help!
NOTE TO NEW MEMBERS: THIS IS SIMPLY A DISCUSSION THREAD, NONE OF THESE PROTOCOLS SHOULD BE FOLLOWED. VISIT THIS THREAD IN ORDER TO KEEP UP WITH PROTOCOLS THAT HAVE BEEN MUCH FURTHER EXPERIMENTED.
Summary of PFS, PSSD & Post Accutane Potential Treatments (as of 12/16)
Gbolduev has stated that drugs like finasteride act as a progestin in the body; meaning, they bind to progesterone receptors. This has many downstream effects, most notably on 3BHSD and many other enzymes (5ar), hormones (estradiol, cortisol, DHT), and minerals (potassium). Eventually, the body gets thrown into a chronic state of imbalance from which it is hard to recover.
The thought is that some people suffer from agonized prog receptors, while others suffer from antagonized receptors. Here are a few treatment protocols that were suggested for each case:
Case #1 – agonized receptors
1) Progesterone 50-400mg ED for 1 week w/ calorie restriction; then start on zinc + NAD
2) Magnesium 1000mg + B6 100-200mg + NAD 2000mg + zinc 100-200mg
3) Methylation using Thorne Multi-Vitamin Elite
4) Thyroid hormone + zinc + NAD
Case #2 – antagonized receptors
1) Copper 10mg ED; after 3 weeks add in zinc + NAD + magnesium + manganese + B6
2) High-dose manganese + co-factors
3) Estradiol + DHT
4) Andro + relora + licorice root
5) Pine pollen + relora + licorice root
6) Pine pollen + relora + nettle
There are ongoing trials with RU486 taking place. Others have tried fasting, methylation, pine pollen, and Ella (another anti-progestin) with good results. If you are unsure of which “case” you might fit into or have any questions in general, please post here. There are many people willing to help!
NOTE TO NEW MEMBERS: THIS IS SIMPLY A DISCUSSION THREAD, NONE OF THESE PROTOCOLS SHOULD BE FOLLOWED. VISIT THIS THREAD IN ORDER TO KEEP UP WITH PROTOCOLS THAT HAVE BEEN MUCH FURTHER EXPERIMENTED.
Summary of PFS, PSSD & Post Accutane Potential Treatments (as of 12/16)
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