PSSD Discussions

[Helen]

I think PSSD is connected to deficiencies in magnesium and manganese and possible copper.

As I saw on the blood tests, people with PSSD have high aldosterone, and high progesterone. We could try to lower aldo with magnesium and kill 3 beta hsd with manganese.

Both of these minerals increase binding to 5-HT(1A) receptor.

Enhancement of agonist binding to 5-HT1A receptors in rat brain membranes by millimolar Mn2+. - PubMed - NCBI


SO you can try those 2.

or try manganese copper potassium magnesium selenium vitamin D methionine. ( fast oxidizer route)


Also manganese is connected with histidine, since manganese activates carnosinase. And when histidine is really low, manganese is being used hard. to break down carnosine and this can cause anorexia.

Manganese also breaks down arginine, and so when it goes down, herpes outbreaks can happen.

 

[DGS94]

I'll try these out when I'm back from holiday in a couple of weeks. What kind of doses would you recommend?

 

[Blue88]

I think PSSD is connected to deficiencies in magnesium and manganese and possible copper.

As I saw on the blood tests, people with PSSD have high aldosterone, and high progesterone. We could try to lower aldo with magnesium and kill 3 beta hsd with manganese.

Both of these minerals increase binding to 5-HT(1A) receptor.

Enhancement of agonist binding to 5-HT1A receptors in rat brain membranes by millimolar Mn2+. - PubMed - NCBI


SO you can try those 2.

or try manganese copper potassium magnesium selenium vitamin D methionine. ( fast oxidizer route)


Also manganese is connected with histidine, since manganese activates carnosinase. And when histidine is really low, manganese is being used hard. to break down carnosine and this can cause anorexia.

Manganese also breaks down arginine, and so when it goes down, herpes outbreaks can happen.

Hi Gbol, thank you for taking the time to provide these options. Are you looking to provide similar protocols but for hair loss in the other section of the forum?

 

[Jaxx]

Awesome to see a PSSD suggestion!
The multi vitamin i was taking actually had most of this. You reckon the amount is too low or i should try option 2 instead

Vitaminen Vitamine A (RE) (25% als betacaroteen) 800 µg100Vitamine B1 1,4 mg127 Vitamine B2 1,75 mg 125 Vitamine B3 (niacine)(NE)20 mg125 Vitamine B5 (pantotheenzuur)7,5 mg125Vitamine B6 2 mg143Vitamine B8 (biotine) 62,5 µg125Vitamine B11 (foliumzuur)200 µg100Vitamine B122,5 µg 100Vitamine C 100 mg125Vitamine D5 µg100Vitamine E (α-TE) 15 mg 125Vitamine K 4030 µg40
Mineralen Calcium 162 mg (20%) Chroom 40 µg (100) Iron 5 mg (36%) Fosfor 125 mg (18%) Iodine 100 µg 67 Copper 500 µg (50%) Magnesium 100 mg (27%) Manganese 2 mg (100%) Molybdeen 50 µg 100 Selenium 30 µg (55%) Zinc 5 mg (50%) Luteïne500 µg *

 

[Helen]

Also it looks like it could be directly connected to zinc finger protocol. And may be histidine deficiency along with copper deficiency.

Manganese could be just used a lot now to break down carnosine.. So we have possibilities to try

 

[barbaar]

@gbolduev are there any specific tests pssd people should do to give you more information? Or can we follow the PFS test recommendations?

 

[Shadow]

@Ghost theory is about 5HT1A receptors being desensitized thus causing the problems. Then I ask, we know that this desensitization always occur while taking SSRI, so, why the symptoms start or worse after stopping the drug? If the desensitization was the responsible, why we didnt have the full symptomatology while on SSRI?

I still raise the neurosteroids flag. Neurosteroids - PFS, PSSD and PAS

 

[Helen]

@Ghost theory is about 5HT1A receptors being desensitized thus causing the problems. Then I ask, we know that this desensitization always occur while taking SSRI, so, why the symptoms start or worse after stopping the drug? If the desensitization was the responsible, why we didnt have the full symptomatology while on SSRI?

I still raise the neurosteroids flag. Neurosteroids - PFS, PSSD and PAS

why would you have full symptomatology while you are feeding serotonin with SRRI, providing extra levels of serotonin. When you stop the drug , then the normal physiological levels of serotonin and even high levels of it , cant provide enough serotonin to match SRRI levels.

this is why serotonin is raised which increases progesterone and kills its breakdown into neurosteroids. Since otherwise estrogen will break down serotonin and you cant afford it.

I am pretty sure it is all about zinc finger. And manganese and magnesium loss is just to provide extra cysteine and histidine. Also probably zinc is lost HUGE

 

[Shadow]

why would you have full symptomatology while you are feeding serotonin with SRRI, providing extra levels of serotonin.

It is a good point, but if this was the case, reinstating the drug would at least alleviate the symptoms right?

 

[Helen]

It is a good point, but if this was the case, reinstating the drug would at least alleviate the symptoms right?

Probably yes, unless your serotonin production just burned out already from pumping huge serotonin levels all the time.

Dont forget, body will be using zinc finger, and slowly histidine will burn out along with cysteine and zinc, this will totally block the conversion of folate into its active form. And this stops methylation totally. So you go back on SRRI , and there is no nothing to work with anymore.

I think this is the mechanism for PSSD.

 

[Shadow]

Probably yes, unless your serotonin production just burned out already from pumping huge serotonin levels all the time.

Dont forget, body will be using zinc finger, and slowly histidine will burn out along with cysteine and zinc, this will totally block the conversion of folate into its active form. And this stops methylation totally. So you go back on SRRI , and there is no nothing to work with anymore.

I think this is the mechanism for PSSD.

I tried reinstating and I ended up even worse, not only from sexual sides.

Whatever the mechanism is, it needs to have the ability to do what he does very fast! @Ghost was affected by 4 pills only! I know of people who took 1 pill and developed nerve pain, there are women who got restless genital syndrome after a week of srris, this drug just dont make sense...

 

[Helen]

I tried reinstating and I ended up even worse, not only from sexual sides.

Whatever the mechanism is, it needs to have the ability to do what he does very fast! @Ghost was affected by 4 pills only! I know of people who took 1 pill and developed nerve pain, there are women who got restless genital syndrome after a week of srris, this drug just dont make sense...

No reason to go on it, it already caused deficiencies. so taking it again makes no sense.

 

[Shadow]

No reason to go on it, it already caused deficiencies. so taking it again makes no sense.

Yep, I wish I knew it before, at the time I trusted my Dr... unfortunately

 

[Crushed]

Gbolduev, Are there any specific tests you would prefer for members to have done now that you are looking at PSSD separately from PFS? Or do the same recommendations apply? I'm having tests done soon.

Thanks

 

[raven]

I have very high zinc levels, could this indicate anything

 

[Jamie]

I have very high zinc levels, could this indicate anything

Blood test or hair test?

 

[raven]

blood test

 

[Jamie]

blood test

Do you have Iron panel, copper tests also?

 

[raven]

My copper result was in the middle of the reference range and I didn't get a full iron panel but here was the result for Iron:
Iron 26 umol/L (10.6 - 28.3)

 

[Jamie]

Zincabosrbtion
There is something about absorption of zinc but I don't know what does this exactly mean