Sex Hormone Binding Globulin, Borderline low Testosterone and Cortisol

[Elision]

Does anyone have a better understanding of the relationship between SHBG, Testosterone and Cortisol? I thought that usually when SHBG was high, usually free testosterone is low (bound to SHBG) and cortisol is high (trying to stimulate SHBG).

Does stress have a relationship with increased SHBG, which then binds to excess testosterone, and in the long term (stress) leads to low cortisol also?

Last few blood tests show
SHBG 107 HIGH
Free Testosterone 8 ALMOST UNDER MIN REFERENCE RANGE
Cortisol 235 NOTED AS BORDERLINE LOW

Estrogen to Progest ratio and totals are normal

 

[bruschi11]

Wouldn’t worry about the actual hormones. What they tell us is that you’re sick. Esspecially when they are shifted to that badly to that degree.

I think working on gut and mineral balance is certainly key when it comes to fixing these health problems. Maybe look for Lyme, have a Geneva diagnostics stool test done, and definitely have hair test done.

 

[Elision]

@bruschi11

Doctors in Aus are rarely, if ever, willing to test for Lyme disease :/ The Geneva stool test appears to only be accessible for those in the US, do you know of an Aus equivalent?

And my hair tests are in this thread https://hackstasis.com/threads/elisions-health-log.1351/#post-42270

 

[Area-1255]

High SHBG is usually caused by high E2. You can use Arimidex + Proviron to reduce it. Or a test-booster like Pro 17.

 

[Elision]

High SHBG is usually caused by high E2. You can use Arimidex + Proviron to reduce it. Or a test-booster like Pro 17.

What about something like Estroblock?

 

[Elision]

High SHBG is usually caused by high E2. You can use Arimidex + Proviron to reduce it. Or a test-booster like Pro 17.

@Area-1255 Also, I don't have high E2. It was well within normal range, and the ratio of E2 to progest was normal too. Supposedly SHBG can increase when there is a problem with cortisol though

 

[Helen]

SBHG increases and decreases with the thyroid.

your TSH is 0.76, indicating faster thyroid or lower calcium, vitaimin D , or may be copper

In faster metabolism testosterone to DHT conversion goes down. thus kids and when you are young have less body hair, more health.

And when people get older, they get higher DHT , hair on their back, bald etc. Slower metabolism ( slower thyroid ) and low Sex binding globulin

 

[Elision]

SBHG increases and decreases with the thyroid.

your TSH is 0.76, indicating faster thyroid or lower calcium, vitaimin D , or may be copper

In faster metabolism testosterone to DHT conversion goes down. thus kids and when you are young , less body hair, more health

And when people get older, they get higher DHT , back hair, bald etc. Slower metabolism ( slower thyroid ) and low Sex binding globulin

@Helen Have you seen my hair test results? My Ca/K ratio was like 33, indicating slow thyroid and normal copper

https://hackstasis.com/threads/elisions-health-log.1351/#post-42307

 

[Helen]

the only test I see is 4 lows with high phosphorus, indicating fast burned out metabolism.

 

[Helen]

thyroid usually takes out potassium out of the cell. May be you had iron problems or b2(b6) problems along with copper may be vitamin A also. and this caused lower NAD( which decreases progesterone ) . and now you cant put potassium in the cell. thus probably reverse t3 went up a little. and cortisol is low since progesterone is not there to get cortisol from


Are you following traceelements program?

 

[Elision]

the only test I see is 4 lows with high phosphorus, indicating fast burned out metabolism.

@Helen So you're saying the ratio doesn't matter because I'm in four lows pattern? Did you see the second test, where I went into 3 lows (Mag went up, phos went down)?

 

[Helen]

@Helen So you're saying the ratio doesn't matter because I'm in four lows pattern? Did you see the second test, where I went into 3 lows (Mag went up, phos went down)?

Second test is the same body chemistry, you just took magnesium or something or b6

B6 is appropriate in this body chemistry to increase energy.

 

[Elision]

thyroid usually takes out potassium out of the cell. May be you had iron problems or b2 problems along with copper. and this caused lower NAD. and now you cant put potassium in the cell. thus probably reverse t3 went up a little. and cortisol is low.


Are you following traceelements program?

@Helen Reverse T3 was 248 pmol/l

I haven't done a trace elements program as yet. The practitioner I was with didn't suggest following it. She suggested B Vits, Copper and Molydenum, plus nettle and tribulus (this did help regulate my cycle). I never actually got the supplement recommendation from interclinical labs

 

[Elision]

Second test is the same body chemistry, you just took magnesium or something or b6

B6 is appropriate in this body chemistry to increase energy.

@Helen Yep, second test I was taking the equivalent of 600mg mag from mag chlor and 25mg B6 (plus other b's). Do you think this was actually helping me, or just propping up?

 

[Helen]

I would test your progesterone , and if that is really low I would look to support IDO enzyme. iron b2 b6 vit A and then take some potassium and see if this raises your cortisol.

YOu need to go on TEI program, why guess. they know what to do in this body chemistry

 

[Elision]

I would test your progesterone , and if that is really low I would look to support IDO enzyme. iron b2 b6 vit A and then take some potassium and see if this raises your cortisol.

YOu need to go on TEI program, why guess. they know what to do in this body chemistry

@Helen Last test progesterone was around 50 and normal range is >6

 

[Helen]

@Elision you also can test b1 and b2 levels in blood. b2 is connected to iron metabolism and molybdenum( both of which you show low on your hairtest)

may be there is an imbalance between b1 and b2

 

[Elision]

@Helen Thanks, will check my B1 and B2 when I retest iron and cortisol. I do take 10mg of B1 and 10mg of B2 at the moment, so I imagine it may be ok?

I find taking the B's do really help keep me more calm and even, although I also take Gaba and l-theanine with them, so can't be sure what's doing it.

I'm wondering though, why the iron won't go up, even though I've been taking the b's, if they are most of the problem?

 

[Helen]

@Helen Thanks, will check my B1 and B2 when I retest iron and cortisol. I do take 10mg of B1 and 10mg of B2 at the moment, so I imagine it may be ok?

I find taking the B's do really help keep me more calm and even, although I also take Gaba and l-theanine with them, so can't be sure what's doing it.

I'm wondering though, why the iron won't go up, even though I've been taking the b's, if they are most of the problem?

Iron is dependant on a lot of things. like manganese , copper, vitamin A. riboflavin molybdenum

what is your iron levels in blood are they high or low?

 

[Elision]

Iron is dependant on a lot of things. like manganese , copper, vitamin A. riboflavin molybdenum

what is your iron levels in blood are they high or low?

@Helen Iron levels are always either in range or high but ferritin sits between 10-25ug/L. The only time it's gotten a little higher was when I was taking copper and it went to 48

Re Testosterone, my total T was ok, but the free T was low because the SHBG was so high. Can this perhaps mean that the T is not the cause of the high SHBG?