Anyone try Sulbutiamine for PFS?
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Niles
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Interesting thought - I may have to try this out. I used sulbutiamine as a pre workout prior to PFS and noticed it did give me good mental and clean/non-jittery physical energy, but a tolerance built very quickly. After the first three days of use, I had to scale back to using just once a week to get any sort of effect (commonly reported). I wonder what the reason behind the quick build in tolerance is, and what that would mean for taking it while in PFS.
[EDIT]
Just used my bulksupplements free sample to get some. Will be trying this soon.
[EDIT]
Just used my bulksupplements free sample to get some. Will be trying this soon.
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I assume, that same as thiamine this will cause zinc deficiency . May be this is a reason why zinc is not torelated in PFS state by many since zinc by increasing insulin puts pressure on b1. I wonder if b1 in this form or hcl form along with zinc or copper can help
So many people try to load up on thiamine , but then find themselves with hypokalemia, weakness .. This is why in electrolytes protocol i rec to take b1 and folic acid with electrolytes or zinc. I guess it is possible, that thiamine is used up by finasteride heavily and zinc is lost at the same time. And then there is no stomach acid to absorb both and oxidative stress overwhelms the system.
So many people try to load up on thiamine , but then find themselves with hypokalemia, weakness .. This is why in electrolytes protocol i rec to take b1 and folic acid with electrolytes or zinc. I guess it is possible, that thiamine is used up by finasteride heavily and zinc is lost at the same time. And then there is no stomach acid to absorb both and oxidative stress overwhelms the system.
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Just remembered something that I think is relevant: Thiamine (and hence Sulbutiamine) are similar in action to Acetazolamide. Both are sulfur-based carbonic anhydrase inhibitors. Therefore, supplementing Sulbutiamine can be very beneficial as long as necessary cofactors are also supplemented (as described in the first post on this thread: PSSD Proposed Solution)
I suspect that Sulbutiamine can replace Acetazolamide, for the same effect, although I am not sure at what dosage level.
Please note, although this is a PFS thread, the remaining alkalosis is common for both PSSD and PFS, so I think this is useful to consider.
I suspect that Sulbutiamine can replace Acetazolamide, for the same effect, although I am not sure at what dosage level.
Please note, although this is a PFS thread, the remaining alkalosis is common for both PSSD and PFS, so I think this is useful to consider.
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Interesting, did you try supplementing potassium at the same time you took it?
Yes, absolutely. And you also want to supplement Magnesium, too, as B1 antagonizes B6, and B6 retains Magnesium. Or/and add some B6.
B vitamins are complex
Orion
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Yes, absolutely. And you also want to supplement Magnesium, too, as B1 antagonizes B6, and B6 retains Magnesium. Or/and add some B6.
B vitamins are complex
Since I cannot easily get ACE/diamox will be trying high dose thiamine with B vits, K and Mg electrolyte co-factors. Read some info on accutane that it causes severe thiamine deficiencies and therefore reduces the pentose pathway production of NADPH. Complete saturating the system with B1 seems to be the course to healing this, 1,500mg/day dosages. Not sure for how long though? 1 week, 1 month...
I have oily skin issues that are stopped by high dose pantothenic acid(used long time ago) or malic acid both which seem to increase NADPH production in the Krebs cycle. Hopefully B1 will get the pentose pathway production of NADPH back online. Read that the bulk of our NADPH production(60%) should be completed in the pentose pathway.
Thanks for the info this post too; https://hackstasis.com/threads/pssd-proposed-solution.205/post-3445
you are welcome!
Just keep in mind to balance B1 with B6, Magnesium, Copper, Potassium. B1 is very protective of dopamine producing cells and dopamine neurons, however it does so by "shielding" them from dopamine activation, thus allowing their rebuilding. Therefore, while on B1, you may experience low dopamine symptoms (without dopamine actually being low). Feel free to take a break if you need, or add more B6, which is pro-dopaminergic. It's important to feel in control, as low-dopamine type depression can creep in gradually and you may not be aware at first.
Also, I want to use this opportunity to say that Sodium-Copper-Chlorophyllin is another good form of Copper.