Role of glucocorticoid receptors

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talkingant

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Check out this article on glucocorticoid (cortisol) receptors:

Glucocorticoid Receptors: Gateways to Control Your Levels of Stress, Inflammation, and Anxiety - Selfhacked

Some quotes with my comments in red:

"When the glucocorticoid receptor is over-activated, it becomes resistant to the effects of the glucocorticoid hormones (R). This can cause excessive CRH and ACTH. When ACTH stimulates the adrenals, it can release other hormones like mineralocorticoids and androgens from the adrenals."

"Mutations of the NR3C1 gene (which encodes the glucocorticoid receptor) may also contribute to glucocorticoid resistance (R)." - I have at least two miner alleles in this gene

"Glucocorticoid resistance symptoms are similar to symptoms of low cortisol. In addition, the body compensates by increasing CRH and cortisol. CRH can cause excessive secretion of androgens and steroid hormones from the adrenals...also causes the body to be more vulnerable to HPA axis dysfunction"

"ACTH causes the adrenals to release a lot of androgens (testosterone and DHEA)" - My blood tests show high DHEA and Free Testosterone

"Dexamethasone (a synthetic glucocorticoid/steroid medication) has a high affinity for glucocorticoid receptors" - Some PFS'ers allegedly felt better on Dexamethasone

"Chronic lithium chloride injection increases glucocorticoid receptor production (mRNA expression) in rat brains" - Recently a woman on PSSDForum was cured while taking lithium (among other things)

"High vitamin B6 concentration suppresses glucocorticoid receptor production, while its deficiency enhances the body’s responsiveness to glucocorticoids (R)."

"Curcumin inhibited the glucocorticoid receptor’s ability to change cellular production in a human cell study (R)." - Some PSSD'ers report feeling better on curcumin

"Mifepristone...lowers glucocorticoid receptor activity (R)" - Some PFS/PSSD people here report feeling better after an RU-486 cycle

"Glucocorticoid Receptor Activation Decreases the Expression of 5-HT1A: neuronal serotonin receptor (R)" - This receptor is theorized to be involved in PSSD

Given all these connections, glucocorticoid receptors should be of interest to us here!
 
Helen

Helen

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@talkingant this is what I am talking about. GR and AR are connected like twin brothers

SSRI cause crazy cortisol release, SO when you come off your cortisol can be insensitive. Since SSRI caused constant crazy release of cortisol.

This is why people feel totally cured while on dexamethasone. https://hackstasis.com/threads/pfs-cases-explanations-and-ideas-to-try.1126/

This is the original theory on this forum. This is why I rec'd mifepristone and also this is why i rec'd miferprison together with progesterone, to upregulate cortisol receptor. In case of downregulated receptors.

This is why I was talking about anavar
 
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bruschi11

bruschi11

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Helen said:
@talkingant this is what I am talking about. GR and AR are connected like twin brothers

SSRI cause crazy cortisol release, SO when you come off your cortisol can be insensitive. Since SSRI caused constant crazy release of cortisol.

This is why people totally cured while on dexamethasone.
Click to expand...

Yup. It’s why post fast @freeflow and I and whomever else has likely experienced it- you wake up ready to go in the morning. Fasting sensitizes receptors to cortisol.

When cortisol is high enough and strong (sensitive) enough you’re going to wake up feeling great in the morning. Cortisol is what wakes you up!
 
T

talkingant

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@Helen how would Anavar effect glucocorticoid receptors? This study gave rats DHT and found it reduced GR. This study found male monkeys produced less cortisol when given high DHT. So there is definitely a connection between androgens and glucocorticoid receptors, we just need to figure out the interactions.
 
Helen

Helen

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talkingant said:
@Helen how would Anavar effect glucocorticoid receptors? This study gave rats DHT and found it reduced GR. This study found male monkeys produced less cortisol when given high DHT. So there is definitely a connection between androgens and glucocorticoid receptors, we just need to figure out the interactions.
Click to expand...

anavar is anti DHT. it blocks GR receptor and increases cortisol like crazy

I am still not sure for which case anavar is. but it definately fits one case.

I mean, I suggested mifeprisone together with progesterone to block cortisol receptor. Mifepriston also increases cortisol like crazy . since it blocks the receptor/ The reason why I suggested together with progesterone is since mife blocks progesterone also.

These are the 2 cases I was talking about. If you give someone anabolic. , this increases cortisol receptors. and increase AR receptors.

if you give something androgenic this decreases AR receptors. and decreases GR receptors. Receptors go together.

Since the more anabolism you get the more cortisol you will need.

The less anabolism you will have the less cortisol you will need.
 
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bruschi11

bruschi11

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Helen

Helen

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talkingant said:
@Helen how would Anavar effect glucocorticoid receptors? This study gave rats DHT and found it reduced GR. This study found male monkeys produced less cortisol when given high DHT. So there is definitely a connection between androgens and glucocorticoid receptors, we just need to figure out the interactions.
Click to expand...


talkingant. Lets try this with you , we know all your bloods, Lets try to fix you. Contact me via PM , I will give you my skype.
 
MNK99

MNK99

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What kind of life is this??!?! Why can't I be normalz??
 
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MNK99

MNK99

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Dopamine = cure.
Just like for pssd. Ref other threads.
Mnk go tcb rite now.
 
bruschi11

bruschi11

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I think I’m “wasting cortisol or potassium?” right now with possibly excessive use of ozone baths. Been doing 2 a day. Today I took 3. Putting the little bulb in the tub underneath my anus lol. Getting it as close to gut as possible.

I’m classic wired but tired feeling. It seems like body is just getting rid of my cortisol- cortisol production line moving so quickly. Definitely experiencing high blood pressure.

This is my 6th day on ozone water. It’s definitely excessive where I’m at now. It’s made me herx like crazy but at a faster pace, minds racing a lot. Hence why I’m on here all the time. Haha maybe I have high potassium like @MNK99 currently and it’s making me want to write all the time!

This is my last day using this stuff. I’m making more frequent bowel movements so hopefully it did what I desired it to do and my body can go to a better place when I come off this in the ensuing days.

Anxious to see what happens.
 
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R

RebelWithACause

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I also have the need to write all the time lately. Don't know if it has to do with potassium.

Slowly we are transforming in @Helen

Writing about minerals, vitamins, hormones, fasting, bathing in applejuice
 
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