I was wondering if anyone has gotten their genetic profiles done? It would be interesting to compare our genes and any common mutations in regards to our conditions. For instance, I suffer from pssd. And I’m homogenous for both COMTs. These mutations cause neurotransmitters and estrogens to not clear as quickly, and can cause a lot of problems. Recently I read about a female that has been cured in part by lithium. I started researching lithium and it’s relationship to COMT. Lithium helps those with COMT by helping to work better, and therefore being able to utilize b12. Im giving it a trial in the form of lithium orotate which is otc. Haven’t noticed too much as of yet, started yesterday.
23 and me
- Thread starter Maxin
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MNK99
Well-Known Member
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- 5,560
-I noticed it helped in horrible PFS last yr (I used it like 2-3 days), also now... but I use it infrequently (kind of obsessed with not gaining weight --- stupid).
-Also I wrote before, it helps a lot due to not tolerating NDMA... so Lithium, being a strong NDMA -antiagonist, can help too (unlike say: Collagen/gelatin -- which both hurt digestion).
-Lithium works well to reduce normal agitation, anxiety, extreme hyperactivity, and worse... but, also can make me tired. AND if doses too high, probably I become more inattentive / spacey. (ADHD, mood disorder likely... well both diagnosed ... both true, but whatever).
-Prescription dose lithium would probably eventually screw me over a lot (like 6mo to 2 or 8 yrs later who knows)... like hypothyroid, weight gain, hair loss, aging... and
-lack of emotions.
-I told some people (mostly, guys) try low doses ideally, so the 4.6mg dosage, I try cutting into 4ths, and only on really stressful days do I take 4.6 or more mg... mostly 1.2-2.3mg... or sometimes 2.3 morn and night, but I am not using everyday (anxiously, awaiting TEI results from late August 2018).
-Higher doses should be fine up to maybe 3-4 pills, but may as well keep it low, and cycle it to prevent tolerance, and damage.
-While I still kind of dislike Li, it is like the only thing outside of hardcore drugs that can change moods or anxiety etc "like that". Also, mmj -- but i save for nite or breaks...
-Just a Note: Collagen/Gelatin may have NDMA affects, hence I like Mg and Li for Antagonistic NDMA effects, and cannot tolerate Collagen/Gelatin as much.
-Really it just hurts digestion... but lots of foods do (for 1-2 days... maybe a week if I really ate badly for a week or two or more straight... maybe a month+ then, who knows).
-Bad digestion = worsened mood though and agitation/irritability for me. Before and surely PFS... but getting better, and ws pretty good at times, will be better than that, evntly.
-Also I wrote before, it helps a lot due to not tolerating NDMA... so Lithium, being a strong NDMA -antiagonist, can help too (unlike say: Collagen/gelatin -- which both hurt digestion).
-Lithium works well to reduce normal agitation, anxiety, extreme hyperactivity, and worse... but, also can make me tired. AND if doses too high, probably I become more inattentive / spacey. (ADHD, mood disorder likely... well both diagnosed ... both true, but whatever).
-Prescription dose lithium would probably eventually screw me over a lot (like 6mo to 2 or 8 yrs later who knows)... like hypothyroid, weight gain, hair loss, aging... and
-lack of emotions.
-I told some people (mostly, guys) try low doses ideally, so the 4.6mg dosage, I try cutting into 4ths, and only on really stressful days do I take 4.6 or more mg... mostly 1.2-2.3mg... or sometimes 2.3 morn and night, but I am not using everyday (anxiously, awaiting TEI results from late August 2018).
-Higher doses should be fine up to maybe 3-4 pills, but may as well keep it low, and cycle it to prevent tolerance, and damage.
-While I still kind of dislike Li, it is like the only thing outside of hardcore drugs that can change moods or anxiety etc "like that". Also, mmj -- but i save for nite or breaks...
-Just a Note: Collagen/Gelatin may have NDMA affects, hence I like Mg and Li for Antagonistic NDMA effects, and cannot tolerate Collagen/Gelatin as much.
-Really it just hurts digestion... but lots of foods do (for 1-2 days... maybe a week if I really ate badly for a week or two or more straight... maybe a month+ then, who knows).
-Bad digestion = worsened mood though and agitation/irritability for me. Before and surely PFS... but getting better, and ws pretty good at times, will be better than that, evntly.
Last edited:
Aleksandr
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I got mine done by DNAfit. They said i was sodium sensitive and a sodium retainer, my hair test shows this to be true, all 3 hair tests have high sodium despite cutting way down on salt and sodium rich foods.
No, all you have to do is upload your 23 and me data to genetic genie. It is free.
As an update, this is day three for me in the lithium and my libido is definitely up. I had this weird sensation in my head, like receptors that haven’t been working we’re getting stimulated. And a twitching down there (I am female). Keep getting a surge of libido all day today. It is making me sleepy though. I took 5 mg in morning and evening.
MNK99
Well-Known Member
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- 5,560
-I may not have mentioned, but @Maxin, Lithium is (as far as I can tell) one of the only things that stimulate BDNF (Brain Derived Neurotrophic Factor -- a protein related to nerve cell growth, maturation, and maintenance). Also BDNF is related to nerve growth factor that some talk about.
---This could explain neuro and other sensations, with receptor activation... maybe. Definitely makes people sleepy... Maybe try cutting the dose a bit, or waiting 2-4 weeks to get used to it, and increase water intake as it is dehydrating as well.
- Acute and chronic effects of lithium on BDNF and GDNF mRNA and protein levels in rat primary neuronal, astroglial and neuroastroglia cultures
-ALSO: Other Studies:
Scholarly articles for "BDNF" + "lithium" + "human study"
Inverse correlation of brain and blood BDNF levels in a … - Elfving - Cited by 93
Inhibition of GSK3 by lithium, from single molecules to … - Freland - Cited by 121
… (BDNF) Val66Met polymorphism and plasma BDNF … - Li - Cited by 17
Inverse correlation of brain and blood BDNF levels in a genetic rat ...
Inverse correlation of brain and blood BDNF levels in a genetic rat model of depression | International Journal of Neuropsychopharmacology | Oxford Academic
by B Elfving - 2010 - Cited by 93 - Related articles
Brain-derived neurotrophic factor (BDNF) is an important member of the ..... and FRL rats are in accord with a human study where the mBDNF CSF levels were identical in ... Lithium treatment alters brain concentrations of nerve growth factor, ...Lithium: A Promising Treatment for Fragile X Syndrome - NCBI - NIH
Lithium: A Promising Treatment for Fragile X Syndrome
by Z Liu - 2014 - Cited by 15 - Related articles
May 11, 2014 - A double-blind clinical trial of lithium treatment in FXS patients is ..... With all of the evidence that lithium can reverse fragile X phenotypes in animal models and in the pilot human study(Table ..... BDNF in fragile X syndrome.Inhibition of GSK3 by lithium, from single molecules to signaling ...
Inhibition of GSK3 by lithium, from single molecules to signaling networks
by L Freland - 2012 - Cited by 121 - Related articles
Feb 20, 2012 - Keywords: lithium, glycogen synthase kinase 3, arrestin, Akt, mood ..... To our knowledge, there is no human study implicating GSK3 or any of the other ..... Peripheral BDNFproduces antidepressant-like effects in cellular and ...IJMS | Free Full-Text | Neuroprotective Effects of Psychotropic Drugs in ...
www.mdpi.com/1422-0067/14/11/22558/html
Nov 15, 2013 - Clinical data consist of an uncontrolled lithium case series (n = 3) suggesting ... fluoxetine, sertraline), and BDNF (lithium, valproate, sertraline) and ...... be drawn from the preclinical data until human study is undertaken.(PDF) Neuroprotective Effects of Psychotropic... - ResearchGate
https://www.researchgate.net/.../258701304_Neuroprotective_Effects_of_Psychotropic_...
Aug 1, 2018 - BDNF (lithium, valproate, sertraline) and downregulated AP-1 DNA binding (lithium), ...... until human study is undertaken. Examples of variable ...[PDF]A reduced risk of stroke with lithium exposure in bipolar ... - Deep Blue
https://deepblue.lib.umich.edu/bitstream/handle/2027.42/115969/bdi12336.pdf?... by C Lan - 2015 - Cited by 12 - Related articles
PS-matched subjects with bipolar disorder without lithium use ... (BDNF), which plays a key role in neuronal devel- ... However, only one human study has.Brain-Derived Neurotrophic Factor and Major Depression ...
https://journals.lww.com/.../Brain_Derived_Neurotrophic_Factor_and_Major.1.aspx by JT Rado - 2007 - Related articles
Recent investigations of brain-derived neurotrophic factor (BDNF) support its .... human study by the same group found significantly elevated levels of BDNF ..... electroconvulsive seizures and lithium on brain-derived neurotrophic factor mRNA ...Lithium: A mineral that affects mood, Alzheimer's disease, obesity, and ...
www.geneticlifehacks.com/lithium-a-mineral-that-affects-mood-alzheimers-disease-ob...
Apr 30, 2018 - A human study looked at telomere length in patients with bipolar disorder. ... One effect of chronic, low-dose lithium is an increase in BDNF, ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414989/
---This could explain neuro and other sensations, with receptor activation... maybe. Definitely makes people sleepy... Maybe try cutting the dose a bit, or waiting 2-4 weeks to get used to it, and increase water intake as it is dehydrating as well.
- Acute and chronic effects of lithium on BDNF and GDNF mRNA and protein levels in rat primary neuronal, astroglial and neuroastroglia cultures
-ALSO: Other Studies:
Scholarly articles for "BDNF" + "lithium" + "human study"
Inverse correlation of brain and blood BDNF levels in a … - Elfving - Cited by 93
Inhibition of GSK3 by lithium, from single molecules to … - Freland - Cited by 121
… (BDNF) Val66Met polymorphism and plasma BDNF … - Li - Cited by 17
Inverse correlation of brain and blood BDNF levels in a genetic rat ...
Inverse correlation of brain and blood BDNF levels in a genetic rat model of depression | International Journal of Neuropsychopharmacology | Oxford Academic
by B Elfving - 2010 - Cited by 93 - Related articles
Brain-derived neurotrophic factor (BDNF) is an important member of the ..... and FRL rats are in accord with a human study where the mBDNF CSF levels were identical in ... Lithium treatment alters brain concentrations of nerve growth factor, ...Lithium: A Promising Treatment for Fragile X Syndrome - NCBI - NIH
Lithium: A Promising Treatment for Fragile X Syndrome
by Z Liu - 2014 - Cited by 15 - Related articles
May 11, 2014 - A double-blind clinical trial of lithium treatment in FXS patients is ..... With all of the evidence that lithium can reverse fragile X phenotypes in animal models and in the pilot human study(Table ..... BDNF in fragile X syndrome.Inhibition of GSK3 by lithium, from single molecules to signaling ...
Inhibition of GSK3 by lithium, from single molecules to signaling networks
by L Freland - 2012 - Cited by 121 - Related articles
Feb 20, 2012 - Keywords: lithium, glycogen synthase kinase 3, arrestin, Akt, mood ..... To our knowledge, there is no human study implicating GSK3 or any of the other ..... Peripheral BDNFproduces antidepressant-like effects in cellular and ...IJMS | Free Full-Text | Neuroprotective Effects of Psychotropic Drugs in ...
www.mdpi.com/1422-0067/14/11/22558/html
Nov 15, 2013 - Clinical data consist of an uncontrolled lithium case series (n = 3) suggesting ... fluoxetine, sertraline), and BDNF (lithium, valproate, sertraline) and ...... be drawn from the preclinical data until human study is undertaken.(PDF) Neuroprotective Effects of Psychotropic... - ResearchGate
https://www.researchgate.net/.../258701304_Neuroprotective_Effects_of_Psychotropic_...
Aug 1, 2018 - BDNF (lithium, valproate, sertraline) and downregulated AP-1 DNA binding (lithium), ...... until human study is undertaken. Examples of variable ...[PDF]A reduced risk of stroke with lithium exposure in bipolar ... - Deep Blue
https://deepblue.lib.umich.edu/bitstream/handle/2027.42/115969/bdi12336.pdf?... by C Lan - 2015 - Cited by 12 - Related articles
PS-matched subjects with bipolar disorder without lithium use ... (BDNF), which plays a key role in neuronal devel- ... However, only one human study has.Brain-Derived Neurotrophic Factor and Major Depression ...
https://journals.lww.com/.../Brain_Derived_Neurotrophic_Factor_and_Major.1.aspx by JT Rado - 2007 - Related articles
Recent investigations of brain-derived neurotrophic factor (BDNF) support its .... human study by the same group found significantly elevated levels of BDNF ..... electroconvulsive seizures and lithium on brain-derived neurotrophic factor mRNA ...Lithium: A mineral that affects mood, Alzheimer's disease, obesity, and ...
www.geneticlifehacks.com/lithium-a-mineral-that-affects-mood-alzheimers-disease-ob...
Apr 30, 2018 - A human study looked at telomere length in patients with bipolar disorder. ... One effect of chronic, low-dose lithium is an increase in BDNF, ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414989/
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