This may explain the horseshoe pattern in MPB?

tallglass13

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Many of you guys may have read this before. but it sure brings a realistic view of why men go bald in a horseshoe fashion.

The Mechanics of Male Pattern Baldness
Reposted from David M. Hatch, August 01st, 2010, 2:34 pm



Editor’s note: This is a reprint from the article located at www.MalePatternBaldness.net. All of the work was done by David Hatch, the owner of this website (and the artwork was done by Nathan Pitkin). Efforts have been made to contact him to get him involved in the discussion, but since this has been up since 1997, we have no clue if he wants to participate or even can still be contacted at his given email address.
This theory, however, has great merit and offers some explanation of the “missing link” of hair loss (ex: the PATTERN of MPB, which to my knowledge hasn’t ever been fully explained), and we would like it talked about -and never forgotten if the MalePatternBaldness.net website ever disappears. Hopefully he will join us in the future -but the discussion shall continue regardless!
So, what we will do is post his article IN FULL, and then discuss it amongst ourselves below…​
THE MECHANICS OF MALE PATTERN BALDNESS:
AN ENGINEERING APPROACH

By
David M. Hatch

(Copyright, 1997-2010 David M. Hatch, All rights reserved.)
mechanics-article-graphic.jpg

Thank you for your curiosity. Now lets see if I can maintain your interest. Being a layman, I was able to take a look at this condition known as Male Pattern Baldness without preconceived notions and yet, I lack the basics in both bio-mechanics and physics that the practitioners in those fields take for granted.
I guess the one thing that I have going for me in this case is, while ignorance may not be bliss, it protected me from the “We know everything there is to know about that area, so we never have to look there again”. So, for the time being, please give me the benefit of the doubt and walk with me through the sequence of observations that led to my conclusions.
One of the first things I realized was that we had handed this problem to the wrong people. It should have been given to the physicist, the mechanical engineer, the bio-physicist or the biomechanical engineer. Since it deals with the body, we asked the medical profession to address it. So far they haven’t gotten back to us yet with anything but sketchy results. Fiddling with DNA will be fine for future generations but what can we do today?
Bring this theory to the attention of any of the specialists mentioned above and they will instantly grasp the concept. Ask a medical person about Male Pattern Baldness and they will mentally consult all the data they have accumulated on the subject, but haven’t personally inspected, and not finding this theory there, will dismiss it.
So let’s see if there’s something we can do in the meantime about getting our hair back while the medicos unlock the secrets of the universe.
Alright, here we go. Let’s observe the obvious. Look at a head with male pattern baldness…In the mirror. As you might have guessed, I have a vested interest in the resolution of this amazingly introverting condition, hence, my acute and heart felt attention. At the age of eighteen, I noticed an abundance of short dark hairs at my hairline and didn’t know what to make of it. Then, not too long after that I noticed the crown receding and the temples cutting back sharply. Then the sickening realization that the hair on the entire top of my head was getting thinner. What was once extroverted attention, crashed back on me and all I could think about was my hair.
Let’s face it, the first thing that people notice about you is your gender and the next is your face and hair. The only thing that could distract that would be if you were on fire. “Well, he was on fire and had thinning hair”. That’s what a witness would say.
Men the world over from that moment of shocking realization to the desperate flight into dozens of topical remedies to wigs that fool no one to the hacking and hewing of surgery, millions of dollars have been spent. I believe the majority of “well adjusted” balding men who are “OK with it” might possibly be coaxed into saying that they wouldn’t mind having their hair back if it were possible. I believe that, like whisky and chewing tobacco, baldness is an acquired taste. I can’t imagine any young man in the entire world at the moment he realizes he’s losing his hair shouting with joy, “Hooray! I’m going bald!” No, I don’t think so. OK, with absolutely no evaluation at all, let’s look at what’s in front of us; let’s observe the obvious. Imagine a balding head rotating before you.
figure-1.jpg

figure-3.jpg

We see a circular area in the center of the back of the head where the hair is the thinnest or nonexistent in the exact center of the circle.
Next, in profile, we see a strip of hair that appears to separate the balding circle in the back of the head from the thinning or bald area at the temple and crown. Face on, we see the hair on the sides of the head the sharply defined “M” line of yesteryear or more advanced, a few sparse hairs at the crown possibly divided by a completely bald;section at the exact crest of the skull.
As the head turns, we see a repeat of the first profile. We observe that there is symmetry to this pattern;left and right are almost identical with slight variations. In the case of the very advanced baldness, we see a very sharply defined border of the hair on the back and sides of the head. In the back of the head, the bald area dips down; almost to where the head and neck come together. In almost all cases the skin of the scalp appears to be shiny. Figure 1
You know, I’m going to stop here for a moment and tell you what got me started investigating in this direction. What would cause the scalp to be shiny? By pulling it tight against the skull. It seems that the one thing that all the practitioners in their field of M.P.B. might grudgingly agree to is that the scalp can be tight. Why hasn’t anyone asked the question how can a scalp be tight and then proceed to look into it to see if there might be some connection? This made me wonder about the nature of stress. What is it?
I think I’ve come up with a tidy definition.
Stress is the resistance to or against something approaching, present; or departing. All things departing were once present and all things present were once approaching. Look at your own life, and every scenario can be distilled to this basic.
OK, do I hear the grinding of teeth?; A little too much of the obvious? Hang in there folks. Now our story takes an interesting turn. We now are going under the skin of the head. Where we stop is at the galea, that tendon like membrane that the scalp is bonded to. Here we see the bilateral symmetry (both left and right sides alike) of the small muscles that attach to the galea.
I’ve included an illustration from some anatomy books for credibility; but Nate Pitkins’ illustrations really communicate the situation.
As an aside, I was wondering what the galea and its attaching muscles were designed for. Possibly the pumping of spinal fluid prior to the hardening of the sutures of the skull?
But I’m drifting, ...back to the story.
figure-4.jpg

Underneath the galea separated by a thin membrane we see the large muscles that close the jaw and that this muscle mass climbs quite a ways up each side of the skull. Interestingly, it appears that the front attachment of the galea to the muscles of the forehead looks surprisingly like the line of a normal hairline. In other words, the normal hairline follows exactly the line where the galea attaches to the muscles of the forehead.
In profile, we see the clamshell shaped muscles that attach the galea to the side of the head. Please note the shape of these muscles. They are fan shaped so that when contracting, they exert a pull across an area of almost 150 degrees.
On the back of the head we see the two muscles attached to the galea exactly where the flat plates of the skull end and the sharply curved dome of the skull begins.
figures-3-5.png

Also, of major importance to this theory are the muscles that attach to the back of the ear. In some people these muscles are under voluntary control and they can move their ears at will.
My theory, according to what I have been able to observe of the male pattern and the underlying structure of the galea, its muscle attachment points and the shape of the skull is this:
The scalp and its capillary bed are bonded to the galea, which actually floats over the skull and is only attached to the skull by the muscles described above. These muscles, for some reason, arrive in a state of continuous contraction. Because of the mirror image placement (left and right side) of these muscles, as they contract, they create a down force by tightening the galea/scalp unit against the curve of the skull sufficient to impede blood flow to the hair follicles.
If you were to remove the curve of the skull and could see the opposing attachment points across a flat surface, it would look exactly like the attachment and tightening points of a drumhead. Kind of makes me think of a reverse Eskimo blanket toss thing. Only instead of Eskimos twanging one of their fellows into the air, these muscles attached to the galea are trying to twang you into the ground and the only thing that happens is you lose your hair.
Let’s start with the fan shaped muscles on the sides of the head. When it contracts, it’s pulling along a 150-degree radius inward toward one point.
figures-3-6.jpg

figure-1.jpg

Well, on the opposite side is the mirror image muscle doing the exact same thing. When this tug of war is done over the curved surface of the skull, you get some interesting down force multiplication.
Let’s apply this theory to the pattern and see if it works. If you were to have two equal and opposite forces being applied across a curve, where would the force be greatest? At the exact center or highest point of the curve. Where does the bald spot start? At the center! As it grows, it radiates symmetrically. Why is it that when these muscles contract over the flat plates of the skull there is no hair loss? No curve, no down force, no blood flow impediment. You remember those muscles I mentioned earlier? The ones behind the ears that pull them back? Well, when those contract, guess where the slack gets taken up. Right, these amplify the down force exerted by the side muscles enormously.
Now let’s take a look at how the side muscles affect the crown of the head. Apparently, this kind of never ending muscular contraction is called Biological Tension. In the case of hair loss, it only has to be great enough to defeat the push of normal blood pressure. When that happens, no nutrients in and no waste out. The follicle starves to death.
Let’s go back to looking at the mechanics of the structure for a moment. Where the scalp/galea bond ends along the forehead, the fatty layer and capillary bed are at their thinnest.
To use an example, think of when you’ve climbed into a bed where the top sheet is very tight and your feet are taking positions you never thought they could. Where is this sheet tightest? At your feet where it curves down and under the mattress. Where is male pattern baldness usually first noticed? At the crown and temples. Let’s use the pattern itself to explain how the side muscles affect blood flow to the scalp. It’s interesting to note that in so many cases of M.P.B. at the crest of the skull there appears to be an area at the exact center where the hair is thinner or nonexistent and that is bordered on each side by hair that is a little thicker. This balder area is usually 1/4 to 3/4 inch in width.
Back to the example of the tight sheet but this time stick the hood of a ‘37 Buick with the nose toward the foot of the bed. Where is the sheet tightest? At the hood ornament! It appears that most skulls have this raised crest of bone and that introduces a higher elevation and a sharper curve and this multiplies the down force even more. Hence, less blood flow equals faster hair loss along the crest than along the bordering sides.
All right, let’s move on to those pesky muscles at the back of the head.
figures-3-5.png

Now it’s interesting what happens when these muscles haul down on the galea. Because of the geometry of the skull, (some what egg shaped looking at it from the top) when the left side contracts, the resistance occurs where the galea attaches over the right eye and right temple. Vise versa for the right side. It’s interesting that these muscles pull back in an “X” configuration. Right back pulls left front, left back pulls right front.

figures-1-5.png

figure-4.jpg

Because of this cross pull on the scalp, and due to the topography of the skull sometimes you will see those little “islands” of hair at the crown of the head where the counter forces neutralize each other. (David Letterman).
Once again, back to the bed sheet analogy. The pull of the muscles on the back of the head squeezes the scalp down against the curve of the skull along the attaching line at the forehead and temples where the scalp is thinnest.
There’s one more thing that this theory explains. Why is there a strip of hair that seems to separate the bald spot in the back and the one on the crown like the band on headphones? The reason that this area is one of the last to go is because of the soft tissue of the jaw muscles gives under the compression of the scalp over them.
So as you can see, the combined pull of these six muscles creates a system of down force on the scalp that is perfectly balanced and quite complete.
THE HANDLING
What needs to be done is to release the scalp capillary bed from the constant down force generated by the muscles attached to the galea so that blood flow can be re-established to the whole scalp. The simplest and least invasive technique would be to inject those muscles [back of head, behind ear] with Botox used already to relax muscles between the eyes . Botox lasts only four to six months and severing the muscles surgically would be permanent. I recommend small vertical incisions over each muscle group and the horizontal cut done under the scalp.
A NOTE OF CAUTION (To the doctors who will perform this procedure): I do not recommend the use of Botox on the side muscles since they could not be injected without affecting the large jaw muscles that are just underneath them. All the other muscles [back of head, behind ear] are isolated and can be addressed safely.
WHERE DO WE GO FROM HERE?
Once the underlying scalp muscle tension is handled permanently, all the M.P.B. handlings that are on the market will explode with enhanced effectiveness in the re-establishment of the capillary bed of the scalp.
IN CONCLUSION
This theory and handling are specifically and exclusively focusing on the condition known as Male Pattern Baldness. So class, your homework assignment is to look at the balding heads around you and see how this theory might apply. It is my belief that this condition is caused only by the loss of blood flow to the hair follicles and if blood flow can be restored, then maybe the follicles could be encouraged to once again do what they do best.
Unfortunately, there is no way that I can patent this procedure and become a billionaire overnight, so please get it to the community of plastic surgeons so that they can make even more money.
The beauty of this theory is the simplicity with which it can be proved or disproved.
Both the Botox and the surgery are minimally invasive and at this point I would recommend that only the muscles behind the ears and back of the head be addressed for now.

figures-3-5.png

Thank you for your time and attention, please feel free to contact to me with your thoughts on this theory.
I would like to thank and recommend the prodigiously talented Nathan Pitkin, the Jimi Hendrix of pen and ink for his amazing drawings that convey the concept better than any words.
Copyright, 1997-2010 David M. Hatch, all rights reserved.
www.MalePatternBaldness.net.
 

Helen

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@tallglass13 When using chelators, I lost my hair every single time in a horse shoe pattern within a month.
It is possible the muscle got more tense of course ,but I think it has to do with nitric oxide and glutathione.
 

mattyb

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I like it, but it's not all encompassing. This explains the pattern of hair loss, but not the physiological mechanism of hair loss and why it happens to only men vs. women.

Another interesting aspect of the scalp is that the veins of the upper scalp are among the few veins in the body that completely lack valves to prevent backflow of venous blood. So you get a toxic buildup of metabolic waste in the scalp. I could see tension in the galea compressing the veins further, limiting outflow of venous blood and encouraging select pooling. Women overcome this because they are much better at adapting to valvular dysfunction due to the vasculogenic stimulation from female sex hormones used to promote vasculogenesis in the fetus. This is why women are much more likely to develop spider veins and varicose veins, whereas men are much less likely to develop these but much more likely to encounter MBP.

Short men are also more likely to experience hair loss, but one would think that arterial blood flow would actually be better in short men vs. tall men, since it's easier to pump blood up to the top of the head. So arterial blood supply to me doesn't make as much sense. Short men would receive blood quicker from the heart, but wouldn't have any advantage in venous clearance, so would be more likely to quickly build up toxic metabolic byproducts in the scalp, impeding the function of hair follicles and causing their atrophy. Not only that, but DHT is strongly angiogenic - so if we though it was about arterial blood flow, then DHT would help hair loss. But that's not really the case.
 

Aleksandr

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@tallglass13 seems like this is from ages ago. Did anyone ever have the operation or botox their galea?
 

tallglass13

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I trust you @Helen, but the way this author describes how the down ward pull , and the peak on the top of the head. Also, how uniform the balding is on each side whether its the temples or the crown, the end result is very even and uniformed hair loss. But increasing our NO and glutathione systems will still be priority for protocols, since it affects other areas of our health.
 

tallglass13

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I think when people take spironolactone or finasteride, they are lowering aldosterone, which then decreases the volume of the blood , abdomen, scalp, everything. DHT causes larger muscles and maybe overgrowth of the muscles surrounding the galea. So when you go transgender, everything gets smaller, and the higher progesterone and estradiol gives hair the thickness.
 

tallglass13

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@Ingeno , the hairs can be revived. I posted some picture of transgender Male to female , who regrow hair from taking finasteride plus estradiol.
 

MNK99

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Yeah, it's probably bs, people who think they just die... Those cells, or follicles, hence all the weirdos that would rather become female and regrow hair... (I mean, sure if they actually had gender dysphoria, but the hair forums and other places make it seem like full hair >>>> being you, i.e. better than being the male you were). Although the sick hair gains don't lie. Neither does the penis removal nor breast growth and skull changes tho. Also entire gender switch. They were after a better life and now they live it as the girl next door.
 

Helen

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@tallglass13

Usually people have high DHT with hairloss. that means that they are slow oxidizers. This means that GR is overexpressed.

and histidine does not get converted into histamine. Thus there is no arachidonic acid which is needed to GROW hair.

This is why estradiol works, estradiol lowers GR expression. and thus increases histamine. which increases arachidonic acid


The original problem is in redox in the cell
 

mattyb

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@mattyb would follicles that have been 'dead' for a long time be able to be revived in any way?

Most people's follicles don't actually disappear, they just shrink to almost nothing. I've been bald for ten years now, I still have all my hair - it looks like I have a full head of hair in good lighting. The hairs are just so damn thin, fuzzy, and white.
 

Helen

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RedStaR

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You can't use cancer cells as a benchmark, there are many subtypes of receptors in a given type, and the effects are not universal in all bio locations. This oversimplification is very naive and I see it done everywhere on the internet.

Estrogen impairs glucocorticoid dependent negative feedback on the hypothalamic–pituitary–adrenal axis via estrogen receptor alpha within the hypothalamus

https://www.sciencedirect.com/science/article/abs/pii/S0306452208018484
 

Helen

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You can't use cancer cells as a benchmark, there are many subtypes of receptors in a given type, and the effects are not universal in all bio locations. This oversimplification is very naive and I see it done everywhere on the internet.

Estrogen impairs glucocorticoid dependent negative feedback on the hypothalamic–pituitary–adrenal axis via estrogen receptor alpha within the hypothalamus

https://www.sciencedirect.com/science/article/abs/pii/S0306452208018484


yes, I can use cancer cells or any other cells as benchmark.


this study shows exactly the same thing. estrogen downregulated GR expression and now DEX is unable to suppress cortisol))

Taken together, these data indicate that estradiol causes a dysregulation of HPA axis (−) feedback as evidenced by the inability of DEX to suppress diurnal and stress-induced CORT and ACTH secretion.


Stop wasting my time, as I told you already.
 

RedStaR

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yes, I can use cancer cells or any other cells as benchmark.


this study shows exactly the same thing. estrogen downregulated GR expression and now DEX is unable to suppress cortisol))

Taken together, these data indicate that estradiol causes a dysregulation of HPA axis (−) feedback as evidenced by the inability of DEX to suppress diurnal and stress-induced CORT and ACTH secretion.


Stop wasting my time, as I told you already.
Do you even read what I say?

Cortisol reduces it's own mRNA expression too, estrogen inhibits the process likely through regulation of nfkb, the autoreceptor downregulation is a dysfunction of the feedback mechanism, estrogen will always raise baseline cortisol and impair it's negative feedback mechanism. It's not as simple as E1 induces GR resistance.
 

Helen

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Do you even read what I say?

Cortisol reduces it's own mRNA expression too, estrogen inhibits the process likely through regulation of nfkb, the autoreceptor downregulation is a dysfunction of the feedback mechanism, estrogen will always raise baseline cortisol and impair it's negative feedback mechanism. It's not as simple as E1 induces GR resistance.


It is very clear what Estrogen does from that study that you posted . it lowered expression of GR. and thus induced GR resistance LOL

Same exact thing as in my study.
 

RedStaR

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It is very clear what Estrogen does from that study that you posted . it lowered expression of GR. and thus induced GR resistance LOL

Same exact thing as in my study.
It INCREASED cortisol secretion through an intelligent mechanism of blocking cortisol's OWN negative feedback mechanism by lowering Glucorticoid autoreceptor expression in the HPA. Again, there many types and locations of GR and every other nuclear receptor in the body. Each have their own function and crossreactivity with different ligands based on specific circumstances. Generlizations are naive at best.
 

Helen

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It INCREASED cortisol secretion through an intelligent mechanism of blocking cortisol's OWN negative feedback mechanism by lowering Glucorticoid autoreceptor expression in the HPA. Again, there many types and locations of GR and every other nuclear receptor in the body. Each have their own function and crossreactivity with different ligands based on specific circumstances. Generlizations are naive at best.


Taken together, these data indicate that estradiol causes a dysregulation of HPA axis (−) feedback as evidenced by the inability of DEX to suppress diurnal and stress-induced CORT and ACTH secretion.

Our study has shown that treatment of MCF-7 human breast cancer cells with 17-beta estradiol (E(2)) produced significant decreases in glucocorticoid receptor (GR) concentrations and GR mRNA levels
E(2) induced resistance to glucocorticoid action may be of potential clinical significance in a number of settings including breast cancer, neuroendocrine response to stress and osteoporosis and could possibly contribute to the differences in glucocorticoid responsiveness among patients.


Evening = stress induced cortisol levels were increased LOL This is a reaction to stress. obviously the levels will be higher if GR expression got downregulated


Intelligent mechanism LOL


STOP your BS already

You claimed complete opposite of all these studies. And now you are repeating after me.



You generalize and guess about everything constantly. same as you did about safety of Finasteride.

And these generalization costed many lives of people who you put on this bullshit.

So please stop talking to me about being naive.
 
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