AR ( androgen receptor ) density and PFS

[Helen]

http://www.associazionevittimefinas...ochemical-Evaluation-of-Androgen-Receptor.pdf


From this it is clear that there is zero problem of AR protein going from cytoplasm into nucleous , just as I mentioned before.

Also it is clear that density of ARs is huge. and increasing AR density in case 1) is just increasing compensation.

They also mention that density might be or NOT compensatory.


so we have 3 things here

1) either denisity is increased as compensatory mechanism since histone signaling ( methylation , acetylation )or zinc finger is impaired which connect those ARs to the DNA. So the body tries hard to make more and more ARS . this is why if you restore the signaling you go bald.

2) or AR overexpressed itself and this high density is causing the shut down of NADPH system ( in some people)



3) there is a problem with potassium system in the body ( progesterone) which then stops folate and all other things from working which then impairs the AR singaling.



lets not forget that finasteride can effect all systems where NADPH is.


NADPH is needed to make thyroid hormone. cortisol, etc

 

[wuf]

http://www.associazionevittimefinas...ochemical-Evaluation-of-Androgen-Receptor.pdf


From this it is clear that there is zero problem of AR protein going from cytoplasm into nucleous , just as I mentioned before.

Also it is clear that density of ARs is huge. and increasing AR density in case 1) is just increasing compensation.

They also mention that density might be or NOT compensatory.


so we have 3 things here

1) either denisity is increased as compensatory mechanism since histone signaling ( methylation , acetylation )or zinc finger is impaired which connect those ARs to the DNA. So the body tries hard to make more and more ARS . this is why if you restore the signaling you go bald.

2) or AR overexpressed itself and this high density is causing the shut down of NADPH system ( in some people)



3) there is a problem with potassium system in the body ( progesterone) which then stops folate and all other things from working which then impairs the AR singaling.



lets not forget that finasteride can effect all systems where NADPH is.


NADPH is needed to make thyroid hormone. cortisol, etc

I think that the way to understand if the cause of PFS is coming from point 1 or point 2, we have to consider the recovered people and what they did to recover and understand what the supplements they have used were impacting to.
Example R Andro: what does it impact? the AR or NADPH system?
other example seen by user Scene, he used minerals. What did minerals impact? the AR or NADPH system?
User CHI, he used diet, excercise and some supplements. what does it impact? the AR or NADPH system?
other used AI, what does it impact? the AR or NADPH system?
ETC...

What I am basically saying is that now we know the root of PFS as you mentioned many times, but we are turning around it, without understanding how and where to act to restore this situation.
In my opinion we should now try to understand what people who recovered did and to wich mechanism, to the AR or NADPH system? or both?
Using this logic I think we should become more practice and we should share people of the forum to jump on some specific protocol, I mean many people together and see the different impact on each other..this will be the way to understand what is working and in which cases.
We now know that we have some common blood issue (acid folic etc...)….That post will be useless if we do not all do those blood tests and try the same protocol sharing people into groups.
I think we really have to be more organized to act this way, and it is possible.. we are just talking and talking from years, I think we should jump on protocols since we have Helen having a great IQ and understanding in this topic.

I mean, I think we should really jump on detailed protocol based on these 2 info we have: root of the problem + recovered protocol from recovered people.
Or stay on TEI for 25 years))) (kidding)

 

[wuf]

I think that the way to understand if the cause of PFS is coming from point 1 or point 2, we have to consider the recovered people and what they did to recover and understand what the supplements they have used were impacting to.
Example R Andro: what does it impact? the AR or NADPH system?
other example seen by user Scene, he used minerals. What did minerals impact? the AR or NADPH system?
User CHI, he used diet, excercise and some supplements. what does it impact? the AR or NADPH system?
other used AI, what does it impact? the AR or NADPH system?
ETC...

What I am basically saying is that now we know the root of PFS as you mentioned many times, but we are turning around it, without understanding how and where to act to restore this situation.
In my opinion we should now try to understand what people who recovered did and to wich mechanism, to the AR or NADPH system? or both?
Using this logic I think we should become more practice and we should share people of the forum to jump on some specific protocol, I mean many people together and see the different impact on each other..this will be the way to understand what is working and in which cases.
We now know that we have some common blood issue (acid folic etc...)….That post will be useless if we do not all do those blood tests and try the same protocol sharing people into groups.
I think we really have to be more organized to act this way, and it is possible.. we are just talking and talking from years, I think we should jump on protocols since we have Helen having a great IQ and understanding in this topic.

I mean, I think we should really jump on detailed protocol based on these 2 info we have: root of the problem + recovered protocol from recovered people.
Or stay on TEI for 25 years))) (kidding)

@Helen
Another thing to consider is my case:
I have moments/days where I do work "perfectly".
How is this possible????
I guess something is changing in methylation or NADPH system and not in AR department, since I think to reduce the HUGE quantity of ARs I have (due to PFS) it won't happen in 1 day (ARs reduced) and 3 days later I feel shit again (ARs HUGE again)… so based on this UPS and DOWNS I think that HUGE ARs are not changing but matbe the NADPH system is changing let me feeling better.. it means that NADPH system is not 100% locked by the HUGE amount of ARs.
Plus, even people who used finasteride and did not have PFS, they had HUGE amount of ARs while using finasteride and once stopped they got to a normal number because the NADPH system started to work again.
I mean, what we do have is like if we are still using finasteride, and finasteride acts on NADPH system, not by increasing the ARs numbers itself, but this is a consequence. so I think NADPH system is the MAIN ROOT and restoring it, ARs will get fixed.

 

[HerrFisch]

@wuf
and dont forget that nadph system is affected by your colitis as well.

Ever tried high dose b1 ? Its crazy how it boosts cortisol

 

[wuf]

@wuf
and dont forget that nadph system is affected by your colitis as well.

Ever tried high dose b1 ? Its crazy how it boosts cortisol

I never tried b1.
Why should I?

 

[wuf]

I want to point something about this threat.
From Melcangi study, we can read that the issue is the 5 alpha reductase enzyme who is missing in tissue of people.
It is missing in different quantity in liquor brain and other tissues depending from the person who got tested.
So, the issue is not about ARs but about 5alpha reductase enzyme not working properly and that is why we have suppressed DHT metabolites.
This is the issue with pfs, no other bullshit.