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  1. TubZy

    Megadosing vitamin E while on finasteride.

    @Jack17 would be interesting to see what happens if you take vitamin E while on avodart. It could get you to 100% and a good way to gauge androgenic effects is hair shedding
  2. TubZy

    Testosterone decreases brain 5AR1 and lowers allopregnenolone.

    How has your hair been during the course of your recovery? As your baseline increases does it correspond with increased hair shedding and oily skin etc?
  3. TubZy

    Testosterone decreases brain 5AR1 and lowers allopregnenolone.

    Same man, that is why CD nuts protocol (mainly the herbs in particular) never had that really good of an effect on me. By the time I started it my sleep improved a lot naturally and led to an improvement in some symptoms mainly sexual. The herbs for me never really did anything on the mental or...
  4. TubZy

    RU / "Mifepristone Challenge" Log

    @jinstewart did you get bloods drawn yet post RU?
  5. TubZy

    Testosterone decreases brain 5AR1 and lowers allopregnenolone.

    Interesting, was it like a daily multiple times per day habit or just like a few times a week (kinda like what @MCurtone is doing with GHB)? And last question do you you still dip today?
  6. TubZy

    Testosterone decreases brain 5AR1 and lowers allopregnenolone.

    Another interesting this for example tobacco and alcohol both increase neurosteroidd but non of it lasts and just a bandaid although @Walker recovered even still while dipping daily lol. @Helen Regarding cortisol and acth The effects of smoking on ACTH and cortisol secretion. - PubMed - NCBI
  7. TubZy

    Testosterone decreases brain 5AR1 and lowers allopregnenolone.

    Yes, I agree. I have tried a million GABA type drugs when I first crashed esepcially when I had bad sleep issues (Xanax, Ambien, phenibut etc) and every single one of them I would get a horrible rebound effect the day (even after one dose). I think the fact that GHB is natural to the body and...
  8. TubZy

    Testosterone decreases brain 5AR1 and lowers allopregnenolone.

    Read post #72 I summarized it a it better. The study shows that GHB has a modulation affect on the receptor rather than strictly just an agonist. Meaning it can adjust up or down depending on the body rather than just say an GABA receptor agonist like Xanax where it will just act on the...
  9. TubZy

    Testosterone decreases brain 5AR1 and lowers allopregnenolone.

    So it seems GHB has a modulating affect on GABA A. This is interesting and maybe that is why you are improving in baseline despite feeling better while taking it @MCurtone since it modulates the receptor rather than act like a pure agonist like for example phenibut, Xanax etc. Effects of GHB...
  10. TubZy

    Testosterone decreases brain 5AR1 and lowers allopregnenolone.

    Right, I posted that full chart in the studies section of the forum as well before. Also, I found this. Brain Steroidogenesis Mediates Ethanol Modulation of GABAA Receptor Activity in Rat Hippocampus jneurosci.org/cgi/content/fu … 521?ck=nck “Ethanol, progesterone, CB34, and GHB stimulate...
  11. TubZy

    Testosterone decreases brain 5AR1 and lowers allopregnenolone.

    possibly if cortisol is not working properly it could alter GR expression. So stressful event demands even more cortisol and since fin is synthetic progesterone it cant convert normally into cortisol like bio-identical progesterone can which could alter GR expression. My stress tolerance was...
  12. TubZy

    Testosterone decreases brain 5AR1 and lowers allopregnenolone.

    Yeah, I crashed from a hardcore preworkout post fin. Like a few weeks after which really crashed me very hard prior to that sides were no that bad. I stopped all stims too and slowly recovered sleep which took about a year. Yes, that is GR. Yeah either the receptors are upregulated or...
  13. TubZy

    Testosterone decreases brain 5AR1 and lowers allopregnenolone.

    Yeah dude same. When I first crashed had all symptoms bad (no sleep, low libido, low drive, no muscle anymore, anxiety etc.) and even bad immune system (mono and stuff). When I came off fin for the first few weeks or so I was hyper sexual than crashed bad which was triggered after taking some...
  14. TubZy

    RU / "Mifepristone Challenge" Log

    If you solely think your issue is prog related and not cortisol and/or both that could be beneficial. However maybe you should try Ella which primarily focuses on blocking progesterone only then you can compare what you felt better on RU vs Ella. Then you can know Cortisol vs prog vs AR etc
  15. TubZy

    Cholesterol levels in PFS

    Mine were always on the highish side as well above normal but not crazy high
  16. TubZy

    Jack17 PFS log

    if you have lower DHT, you probably would just need an even lower dose and/or bigger space in between doses to lessen DHT suppression.
  17. TubZy

    Testosterone decreases brain 5AR1 and lowers allopregnenolone.

    your experiences is exactly similar to mine. Libido and sex drive etc is all pretty fine its mental stuff that is still remaining. Poor response to stress, some brain fog (at times worse than others etc.) and sleep, but sleep has improved much better over time since crash. And I get the same...
  18. TubZy

    Jack17 PFS log

    @Jack17 dut also inhibits both 5AR 1 and 2 so I don't think it's only about half life. Stability could be at play too, maybe by keep both enzymes in balance rather than just nuking one over and over creates a bigger imbalance (like fin) and constant fluctuation
  19. TubZy

    Liberal/Left Wing = Womens cult?

    Most women I know and met that are left leaning are just pretty uninformed and usually just follow the narrative of mainstream media (or just peer pressure from their social friend who appear far to the left so they feel pressured too). I don't won't to say they are stupid but tend not to have...