Agmatine, Allopreg and GABA

[TubZy]

Agmatine seems to stimulate allopreg. Thought this was interesting.

Acute orexigenic effect of agmatine involves interaction between central α2-adrenergic and GABAergic receptors. - PubMed - NCBI

 

[Helen]

Agmatine seems to stimulate allopreg. Thought this was interesting.

Acute orexigenic effect of agmatine involves interaction between central α2-adrenergic and GABAergic receptors. - PubMed - NCBI

yes, I posted to Nina many times that after surgery, they used a2-adrenergic agonist to downregulate gaba expression.

otherwise some people got stuck with overxpressed gaba for years and had mental sides and chronic fatique

GABAA Receptor Theory of Perioperative Neurocognitive Disorders | Anesthesiology | ASA Publications

 

[Nina]

yes, I posted to Nina many times that after surgery, they used a2-adrenergic agonist to downregulate gaba expression.

otherwise some people got stuck with overxpressed gaba for years.

I'm currently on amphetamines (dextroamphetamine 5mg 3x/day) as prescribed by doctor. I'll update in a few weeks if anything changes.

 

[Helen]

I'm currently on amphetamines (dextroamphetamine 5mg 3x/day) as prescribed by doctor. I'll update in a few weeks if anything changes.

cool, mdma is a-2 adrenergic agonist.

 

[Nina]

Btw, i notice when i take GABA increasing stuff my stress tolerance drops to zero for a few days after.

Opposite of most people.

 

[Helen]

@Boris May be this is what is going on?


Gaba puts calcium into the cell. that is how it relaxes the nervous system, stops the firing.

You have high estro high prolactin, meaning that the body is trying to put calcium into the cell.

but it cant. Why? since you are missing inositol. inositol puts calcium into the cell.

this is why it is used for anxiety.

you are missing phospholipids. fin caused deficiency of fats. thus all your hormones dont do anything.

noradrenaline activates phospholipase C to get to inositol.

if there is no inositol. body will contantly convert dopamine into noradrenaline and noradrenaline will increase prolactin.

you give inositol, calcium enters the cell. metabolism slows down. estrogen, will come down, prolactin will fall.

and DHT will go up.


thyroid will come down, cortisol will be needed less. and it will converts with 5AR reductase to its metabolites, this will also increase DHT and its metabolites and since 5AR will be allowed now to break cortisol, 5AR will also increase allopregnenolone.



So as you see in slow oxidizers, you need to decrease gaba and increase estro.

and in fast you want to decrease estro and increase gaba.



Just a theory, it is just weird that you had high prolactin and high estro but your calcium was not going up.

prolactin retains calcium. and noradrenaline by activating a1 receptor increases prolactin and gets inositol phosphate, which is what signals the body to put calcium inside of the cell.


So may be if fin caused fatty acid deficiencies and fat malabsorbtion, then all the phospholipds are screwed. and then no matter what hormones you have in blood. they simply dont do anything. since all of them work thru phospholipids.

 

[Helen]

@Boris second variant, is that something is suppressing your dopamine, and thus high prolactin, but without dopamine converting to noradrenaline, thus no noradrenaline, and without noradrenaline there is no phospholipase activation and no inostiol and no calcium in the cell.

it would be nice if somehow we tested your noradrenaline, if that is high , then you need inositol. I am sure.

if noradrenaline is low and dopamine is low. then you need to see what is suppressing the release.

actually gaba can suppress release of dopamine. serotonin can do it also, and anandamide( made from arachidonic acid) as an example lowers prolactin by decreasing serotonin.

 

[barbaar]

@Boris May be this is what is going on?


Gaba puts calcium into the cell. that is how it relaxes the nervous system, stops the firing.

You have high estro high prolactin, meaning that the body is trying to put calcium into the cell.

but it cant. Why? since you are missing inositol. inositol puts calcium into the cell.

this is why it is used for anxiety.

you are missing phospholipids. fin caused deficiency of fats. thus all your hormones dont do anything.

noradrenaline activates phospholipase C to get to inositol.

if there is no inositol. body will contantly convert dopamine into noradrenaline and noradrenaline will increase prolactin.

you give inositol, calcium enters the cell. metabolism slows down. estrogen, will come down, prolactin will fall.

and DHT will go up.


thyroid will come down, cortisol will be needed less. and it will converts with 5AR reductase to its metabolites, this will also increase DHT and its metabolites and since 5AR will be allowed now to break cortisol, 5AR will also increase allopregnenolone.



So as you see in slow oxidizers, you need to decrease gaba and increase estro.

and in fast you want to decrease estro and increase gaba.



Just a theory, it is just weird that you had high prolactin and high estro but your calcium was not going up.

prolactin retains calcium. and noradrenaline by activating a1 receptor increases prolactin and gets inositol phosphate, which is what signals the body to put calcium inside of the cell.


So may be if fin caused fatty acid deficiencies and fat malabsorbtion, then all the phospholipds are screwed. and then no matter what hormones you have in blood. they simply dont do anything. since all of them work thru phospholipids.

Interesting, when I tried inositol it made me suuuuuper slow, relaxed and sleepy.

 

[Nina]

@Helen "So as you see in slow oxidizers, you need to decrease gaba and increase estro."

Suggestions?
- We know amphetamines can do this.
- Cortisol (?)
- Wormwood on snapback/other GABA agonist.
- What else?

EDIT: Lowering Prolactin in general can do this? Increasing dopamine

"gaba controls the release of CRH and cortisol. SO high gaba decreases cortisol release.

Has been trying wormwood for 2 days to see what it does. Makes me hyper super libido while on it, when it wear off total gaba state- no libido, sweating more. CO2 higher, feels like on benzo"

GABA Activation and Dopamine Suppression

 

[Nina]

GABA excess/deficiency: GABA (Neurotransmitter)

Symptoms Of High GABA Levels
Seldom checked for or treated, excess GABA can result in things like impaired thinking and feeling tired even after getting an adequate amount of sleep. Alcohol and some other drugs can increase GABA, or the effect of GABA, in the body.
People that already have high levels of GABA may experience increased negative reactions to alcohol, barbiturates, benzodiazepines, or other GABA related substances.
Excessive GABA may trigger:
--- Anger.
--- Apathy.
--- Aggression.
--- Verbal Outbursts.
--- Impaired Memory.
--- Reduced Inhibition.
--- Reduced Awareness.
--- Reduced Motivation.
--- Dissatisfaction With Life.
--- Excessive Daytime Sleepiness.
GABA inhibits the effect of other neurotransmitters. This means excessive GABA levels may mimic the symptoms of low levels of other neurotransmitters including acetylcholine, dopamine, glutamate, norepinephrine.

They actually mention @Area-1255 on the bottom of the page with a link to his post about GABA.

Area-1255: Symptoms of High / Excess GABA Levels (How Can You Tell If Your GABA Level Is Too High?)

 

[Nina]

@Helen i feel good on amphetamines which are stimulants, but i feel bad/slower on caffeine which is also a stimulant.

Any theory why?

 

[supernature]

So as you see in slow oxidizers, you need to decrease gaba and increase estro.

and in fast you want to decrease estro and increase gaba.

@Helen
That looks like the one in pyroluria state might be fast oxis, that gaba components are missing, is that make sense.

 

[supernature]

i feel good on amphetamines

At least good to go to a party and enjoy moving all night long and shivers from time to time from those amphets.

 

[ABCnewsat11]

@Helen "So as you see in slow oxidizers, you need to decrease gaba and increase estro."

Suggestions?
- We know amphetamines can do this.
- Cortisol (?)
- Wormwood on snapback/other GABA agonist.
- What else?

EDIT: Lowering Prolactin in general can do this? Increasing dopamine

"gaba controls the release of CRH and cortisol. SO high gaba decreases cortisol release.

Has been trying wormwood for 2 days to see what it does. Makes me hyper super libido while on it, when it wear off total gaba state- no libido, sweating more. CO2 higher, feels like on benzo"

GABA Activation and Dopamine Suppression

Actual estradiol in creams like "Bi-estro", or is this incorrect cause contrarian endocrinology?

 

[Grambo]

I'm currently on amphetamines (dextroamphetamine 5mg 3x/day) as prescribed by doctor. I'll update in a few weeks if anything changes.

What made you decide on Dexedrine? I'm assuming you had some choices. Are you recording your experiences with it somewhere? I'm in the same boat, caffeine does the exact same thing to me. I'm curious how it's working so far.

p.s. That's my sister in your picture!

 

[MNK99]

dex pwns all except desoxyn which is d-meth and illegal but was once prescribed for ADHD (and insomnia and probably fat lazy kids with fat parents).
adderall etc is racemic, l-amp, more cortisol norep etc issues, higher heart rate more sweating, more euphoric if abused, harsher crash (super harsh many say way worse than cocaine, bad or worse than mdma, but depends on tolerance etc). Proper usage, dex is safer, d-amp not mixed amp salts. Levoamp is very harsh.
Ritalin, wellbutrin are DRNI's more similar to coke. I am not Nina but I do enjoy interrupting conversations with random replies. My name is MNK.

 

[Nina]

What made you decide on Dexedrine? I'm assuming you had some choices. Are you recording your experiences with it somewhere? I'm in the same boat, caffeine does the exact same thing to me. I'm curious how it's working so far.

p.s. That's my sister in your picture!

They either use Ritalin (methylphenidate), Strattera or Dextroamphetamine here and my doctor pretty much let me decide which one i wanted to try first. Did some research and most people seem to react best to Dex so went with that.

Liking it so far, trying to take multiple days off of it during the week. Usually 4 days on and 3 days off, sometimes more sometimes less. Dose is pretty low so i don't feel any euphoria but i mainly feel more focused & less distracted by stuff happening around me.

That is not actually your sister is it

 

[Jaxx]

They either use Ritalin (methylphenidate), Strattera or Dextroamphetamine here and my doctor pretty much let me decide which one i wanted to try first. Did some research and most people seem to react best to Dex so went with that.

Liking it so far, trying to take multiple days off of it during the week. Usually 4 days on and 3 days off, sometimes more sometimes less. Dose is pretty low so i don't feel any euphoria but i mainly feel more focused & less distracted by stuff happening around me.

That is not actually your sister is it

I am actually also looking into dextroamphetamine. Did you ever try tonic dopaminergics before (agonists like cabergoline, pramipexole or MAO-B inhibitors?)

 

[Nina]

I am actually also looking into dextroamphetamine. Did you ever try tonic dopaminergics before (agonists like cabergoline, pramipexole or MAO-B inhibitors?)

Nope never tried those

 

[Niles]

What about low-dose fluoxetine (prozac) to increase allo? .5 - 1mg has been shown to increase allo without the ssri properties of typically prescribed doses.

I got a script just for shits awhile back to experiment with low doses, but never ended up going for it.