Brainstorming & Ideas (PFS - Gbol)

[Helen]

As far as i know. no reliable test is really available for this. For TCA's they do test blood serum at the beginning of therapy, but never serotonine, dopamine levels. Only thing alot of PSSD sufferers report is high prog.

Progesterone is raised when you have potassium deficiency.

potassium deficiency turns off the whole axis. that is why DHEA can crash you , since it lowers whole corticosteroid pathway, by tanking iron. And this lowers potassium and thus lowers cortisol.

that is why on Ray peat forum they say DHEA lowers cortisol, they dont undertstand that it lowers potassium and that is why cortisol falls not to kill you.

Then potassium deficiency= raised progesterone and low cortisol.
BUT
I have low progesterone (blood tests) and relative low cortisol (saliva test).
Potassium in ranges (hair and blood tests)

that is why I recommended to you zinc magnesium and potassium and may be some iron with b2. Since you tanked all your axis with DHEA

Your conversion of cholesterol to pregnenolone stopped. that is why you have low progesterone and low cortisol

I gave you advice what to take. I thought you were doing better on it. And then for some reason you start taking copper and following other peoples protocols? WHY?

If you recovered and then crashed with DHEA. You are different. Don't confuse people.

 

[HereToHeal]

I dont knoe what is Depo provera. I repeat the same, the first study that declared that PFS patientes had 5ar metabolites on very low ratios compared to controls was in Dr. Melcangi study, if you have another study pointing to the contrary in open to see it.

Depo provera is Medroxyprogesterone, its used for chemical castration.

What I think that gbolduev is trying to say is that yes, the metabolites are low, but making them go up will not kick the body back to a normal state since something else is keeping them low.

You are PSSD person , right. I was thinking about PSSD. Basically , you give SRRI, you overload the system with serotonin.

What do we get when we overload it with serotonin. We increase MAO A , right ? to break down this extra serotonin.

MAO A is vitamin b2 and copper.


Did you guys measure serotonin levels? after you quit SSRI?

Hey [mention]gbolduev[/mention] thanks for your input. Im a PSSD sufferer too (low estrogen, progesterone within range). Supposedly if I take vitamin b2 an copper together, i will have a good chance of getting cured? is it that easy?

 

[Helen]

Depo provera is Medroxyprogesterone, its used for chemical castration.

What I think that gbolduev is trying to say is that yes, the metabolites are low, but making them go up will not kick the body back to a normal state since something else is keeping them low.

You are PSSD person , right. I was thinking about PSSD. Basically , you give SRRI, you overload the system with serotonin.

What do we get when we overload it with serotonin. We increase MAO A , right ? to break down this extra serotonin.

MAO A is vitamin b2 and copper.


Did you guys measure serotonin levels? after you quit SSRI?

Hey @gbolduev thanks for your input. Im a PSSD sufferer too (low estrogen, progesterone within range). Supposedly if I take vitamin b2 an copper together, i will have a good chance of getting cured? is it that easy?

No. I am just looking at PSSD minerals

 

[HereToHeal]

You are PSSD person , right. I was thinking about PSSD. Basically , you give SRRI, you overload the system with serotonin.

What do we get when we overload it with serotonin. We increase MAO A , right ? to break down this extra serotonin.

MAO A is vitamin b2 and copper.


Did you guys measure serotonin levels? after you quit SSRI?

Hey @gbolduev thanks for your input. Im a PSSD sufferer too (low estrogen, progesterone within range). Supposedly if I take vitamin b2 an copper together, i will have a good chance of getting cured? is it that easy?

No. I am just looking at PSSD minerals

So which of all the theories proposed on this forum (Ella, reservatrol, etc.), would you recommend to a PSSD sufferer? Does it depend on my blood tests?
I dont know which method to try first.

 

[tanedout]

Do you also see a thyroid connection here? Although difficult to explain, i always felt a pressure on my thyroid/throat when a window appeared. Furthermore i noticed several elevated TSH tests on the PSSD forum (no impact on t3/t4, so often without follow up)

This is very interesting! I've not read anyone describe this before, but I know exactly what you mean here - I pretty much always feel pressure on the bottom part of my throat (thyroid location), but I can never work out what this is due to? Have you found anything that alleviates this?

My serum TSH is high, and hair analysis also suggests low thyroid function (and interesting implies likely high TSH which is correct). I'm never sure if this is essentially due to having low potassium or elevated cortisol - what do your bloods indicate? Low thyroid function is a symptom of consistently high cortisol I presume?

 

[Jaxx]

Do you also see a thyroid connection here? Although difficult to explain, i always felt a pressure on my thyroid/throat when a window appeared. Furthermore i noticed several elevated TSH tests on the PSSD forum (no impact on t3/t4, so often without follow up)

This is very interesting! I've not read anyone describe this before, but I know exactly what you mean here - I pretty much always feel pressure on the bottom part of my throat (thyroid location), but I can never work out what this is due to? Have you found anything that alleviates this?

My serum TSH is high, and hair analysis also suggests low thyroid function (and interesting implies likely high TSH which is correct). I'm never sure if this is essentially due to having low potassium or elevated cortisol - what do your bloods indicate? Low thyroid function is a symptom of consistently high cortisol I presume?

My TSH is elevated (although normalizes from time to time) as my T3 and T4 are normal, no medical action is taken. I only had this since pssd i believe

 

[wuf]

I dont knoe what is Depo provera. I repeat the same, the first study that declared that PFS patientes had 5ar metabolites on very low ratios compared to controls was in Dr. Melcangi study, if you have another study pointing to the contrary in open to see it.

I am not saying metabolites are not low. I am saying that I knew they were low even without you telling me about some study. this study is not important to me. I based my research on depo provera which already told me that metabolites will be down.

Low metabolites does not provide you with the solution. LOL there is still no cure for depo provera after 20 year or 30 years of research, although it is researched a lot better and tons of Melcangi like studies done on it.


No one knows how to regulate 5 alpha 1. LOL

and I am telling you how. Just go take resveratrol and see your 5 alpha 1 go on. You dont even know that it is 5 alpha 1

Researching for resveratrol, I found some links telling it is antiestrogenic, seems like to reduce estrogens...because it blocks aromatasi...sure it doent reduce estrogens?
Since this is the last thing we want.
After I crashed with Androstenolone I tried 0.25 arimidex for 3 times and it completelly crashed my estrogens for a long time and it was not funny at all....I think I m in this situation probably more because of the estrogens crash than the Androstenolone crash.
After crashing my estrogens I said BYE BYE to my libido even more than after Androstenolone crash.

 

[Shadow]

[mention]Jaxx[/mention] did you tested your LH and FSH?

Mine are on in the range but very close to the low end. I found this article, and the author talked about it.
https://www.dailymedicaldiscoveries.com/ssris-lower-testosterone-raise-prolactin/

 

[Jaxx]

@Jaxx did you tested your LH and FSH?

Mine are on in the range but very close to the low end. I found this article, and the author talked about it.
https://www.dailymedicaldiscoveries.com/ssris-lower-testosterone-raise-prolactin/

Actually getting these test results next week, so lets see.
Licorise root supp had a major impact on my energy, so cortisol might play a role here somehow

 

[snowball]

Have PFS for last 7 years and just got hair test done.
Just posted the results: https://www.hackstasis.com/viewtopic.php?f=33&t=253

Based on report, appreciate inputs on which PFS protocol to follow.

 

[wuf]

Could someone explaine me why Gboldued got cured again in 10 days and us, despite someone is trying minerals, (Scenes,Joekool etc) is not cured?
He maybe did the right route based on himself (based on his labs) and we are doing a wrong route?

The point is:
We all have understood that minerals can be a decisive route since Gbold got cured in 10 days.. but it has to be personalized.
Gbolduev knows how to do it, we don't.
So now the point is, how to personalized it otherwise I don't see a way out to get cured as he did.

I will try what he suggested me, to use - zinc,magnesium,potassium and maybe some iron, b2.
But I guess it is a bet, aproximate protocol and not a real personalized protocol.
So, how can I/we get a personalized protocol to get cured as Gbolduev did in so short time?

 

[TubZy]

[mention]gbolduev[/mention] What is the reason for boron, is it that it can increase estrogen and DHT?

 

[snowball]

[mention]gbolduev[/mention] [mention]TubZy[/mention]
(If anyone else has expertise or similar result, chime in)
My hair test shows-
(https://www.hackstasis.com/viewtopic.php?f=33&t=253)
-Copper below Normal
-Zinc below Normal
-Sulphur below Normal
-Manganese below normal
-Nickel, vanadium, cobalt below normal
-sodiumotassium low
From interpretation notes: Electrolyte levels suggest hypo adrenal and normal thyroid function

My blood test from 2015 showed high progesterone
Progesterone 0.2 (range <0.2)

Which PFS protocol shall I try? Can you provide inputs?

 

[aybolit]

Hi I have taken accutane and in a lesser degree finasteride about 15 years ago. I think I have low metabolism - low basal temperature, cold hands & feet, fatigue, digestion issues. The worst side is a severe rosacea (facial redness) It may be linked to impaired metabolism of histamine and acetaldehyde. Any ideas guys how to fix/improve it ?

 

[Minime]

I also want to say that we are all running around and around with to many theories....
I think we should make order and hereby is my suggestion after we discusses different theorical possibilities:

1) All of us should take blood and hair tests
2)Compare them each other to understand if we all match with gbold's theory
3)Try to make get out protocols from what the tests are

In my own opinion we could be more organized if we really want to find out something based on real data.. Gbold already put out his theory, but put out also different potential protocols based on his own theory and not on real data coming from our analysis..
I feel we are loosing time talking and talking and trying things just randomly and without real data under our hands.

We should organize a deadline where all of us should get blood/hair thests and then from that data start to discuss it.

I know it is not simple to organize a straight work to collaborate all together but this is the way we should act if we want to get somewhere, otherwise we are endind up to become as Propeciahelp or other forums..just talking.

I think gbolduev should be the director and should suggest us to collect analysis. we should all have the same analisys to check the differences what is similar to get to a common point so to esclude useless protocols or theories.

My 2 cents, but I feel we are not going nowhere since people (as me) we almost know what we are talking about.

WHAT WE SHOULD DO IS KIND OF CDNUTS FORUM, WHERE PEOPLE IS DIRECTED TO TRY A PROTOCOL, AND THAT'S THE WAY TO RUN, NOT GOING AROUND WITH NO CLUE.

Can we do it?

Totaly agree on this, people think Gbold is very good but he and his followers doesnt follow scientific method, but its good to have new theories, count me on that.

Scientific method? What are you talking about? You constanly go off the info from Melganci. I am going off my own tests.
I am totally cured .

You seem to miss that metabolites and regulations dont depend on 5 alpha and depend on other systems like cortisol and gaba system regulation . that is why it does not go back up. on it own. And that is why no matter what you do, you will not be able to put it back on . the only way ON is by increasing estrogen singaling.

LIbido goes up right away when estrogen goes up. That is why estrogen plus DHT -= working libido instant

Now you have to figure out how to increase estrogen . And it is not done by taking estrogen.


Take resveratrol and increase estrogen signaling. and you will see what I am talking about.

You seem to constanly look at 5 alpha metabolites. 5 alpha is closed for a reason. I explained to you why. And to open 5 alpha, you need to increase estrogen signaling. Otherwise you will not open it up.


It is silly to look at 5 alpha metabolites and just think how to increase 5 alpha 1 or 2. It is not about that. It is about . how to fix a system which does not allow 5 alpha to go back on.

[mention]gbolduev[/mention] I’m confused. It’s stated that an increase in estrogen will increase libido. My estrogen is high above range (please see my log), my progesterone is in range and my prolactin is in range (low in range), yet my libido is virtually nothing. So what is wrong with me?
Also, resveratrol was suggested to me to help reduce Estrogen yet it appears resveratrol is being suggested here to increase Estrogen(?)

 

[Scenes]

Gbold says there is a difference between being fixed and being balanced. Fixed means ‘take this and feel better’. Balanced means ‘come OFF of everything and feel better, you’re balanced’.

He himself said he is not balanced yet, just fixed...not sure if that has changed over the last week or so.

Take estrogen and dht and be ‘fixed’. Resveratrol plus haiduts 11-keto dht is like a miracle fix. All symptoms of pfs gone in 2 days. But does it balance me or does it make me worse once I come off???

He has said many times that it’s ultimately not as simple as just taking minerals.

On the other hand, zinc + mang was originally mentioned by him as a 2 month protocol to balance the body:
Lower venous co2, get co2 in to the cell, lower estrogen, chelate copper, optimise thyroid. Don’t think anyone has quite gotten that far yet in experimentation...

 

[MNK99]

@Scenes Nice explanation man. That should answer a lot of people's questions.
I wonder where Papi Chulo is. I'm sure he's getting fair and balanced.

 

[wuf]

Take estrogen and dht and be ‘fixed’. Resveratrol plus haiduts 11-keto dht is like a miracle fix. All symptoms of pfs gone in 2 days. But does it balance me or does it make me worse once I come off???

Did you try this?

 

[Helen]

Anyone who wants to get fixed fast just go resveratrol plus dht route or just resveratrol.

I am still working on the mineral cure. I 'm close.

 

[wuf]

Anyone who wants to get fixed fast just go resveratrol plus dht route or just resveratrol.

I am still working on the mineral cure. I 'm close.

Sorry to bother Gbold.
But resveratrol seems to be an anti aromatase supplements from what I am reading in google.
Mybe the sourse is wrong.
Thanks