CONNECTION LICORICE, INOSITOL, RU, ELLA, PROGESTERONE,LITHIUM

[Helen]

Just wanted to outline some of the connections among all of these for PSSD, PFS, POIS, Accutane

Progestins act on progesterone, cortisol, AR, and MR receptors. I think I did not mention the MR receptor before but it is well known that progesterone blocks that receptor and causes sodium wasting. So if you take progestins, then upon stopping the drug , aldosterone will be very very sensitive.

This can raise sodium in the cell. And I know many people with POIS for instance have severe reactions to sodium, increasing their symptoms substantially.

Anything that blocks progesterone makes aldosterone receptors less sensitive. Also it looks like inositol formation is increased with aldosterone. So taking inositol can decrease aldosterone receptors. Also licorice root acts as aldosterone. and upon stopping decreases aldosterone receptors.

Estrogen raises sodium in the cell. So does aldosterone. So if sodium is high already from too sensitive aldosterone. estrogen will be left insensitive and thus DHT will be downregulated.

We need to explore this route and try combination of anti progestins with licorice, and inositols.

 

[Shadow]

Re: CONNECTION LICORICE, INOSITOL, RU, ELLA, PROGESTERONE

<r>I read some nice info regarding of Inositol.<br/>

<QUOTE><s>

</s>Inositol is a vitamin-like nutrient generally obtained by eating fruits.<br/>
Inositol increases the potency of estrogens by enhancing the subcellular signal-transduction actions triggered by estrogen. (Interestingly, Vitamin C - a nutrient also obtained from fruits - may also enhance estrogen's production or effects.)<br/>
The brain determines how much testosterone to produce by measuring estrogen. Testosterone is the precursor for Estrogen. So increasing estrogen potency will reduce production of testosterone. This occurs both in men and women.<br/>
Too much Inositol can cause significant estrogenic adverse effects such as breast tenderness, breast growth, water retention, heavier menstrual flow, irritability and aggression.<br/>
Inositol is increased by antidepressant treatments and such an increase may be crucial for their effectiveness. Note that estrogen also has antidepressant effects - e.g. improving memory, motivation, competitiveness, drive. Estrogen acts in part as a monoamine oxidase inhibitor.<e>

</e></QUOTE>

<URL url="https://www.reddit.com/r/Nootropics/comments/4g0sn1/does_inositol_lower_testosterone_in_men/"><s></s><LINK_TEXT text="https://www.re...tol_lower_testosterone_in_men/</LINK_TEXT><e></e></URL></r>

 

[Helen]

Re: CONNECTION LICORICE, INOSITOL, RU, ELLA, PROGESTERONE

<r><URL url="http://press.endocrine.org/doi/10.1210/jcem.77.6.8263127"><LINK_TEXT text="http://press.endocrine.org/doi/10.1210/ ... .6.8263127">http://press.endocrine.org/doi/10.1210/jcem.77.6.8263127</LINK_TEXT></URL></r>

 

[Shadow]

Re: CONNECTION LICORICE, INOSITOL, RU, ELLA, PROGESTERONE

<t>Im trying Inositol right now since 2 people recovered from PSSD using it. Im on the second week, 18g day, its seems to have improved my mood and a little bit of my lack of body sensitivity.</t>

 

[Helen]

Re: CONNECTION LICORICE, INOSITOL, RU, ELLA, PROGESTERONE

<r><URL url="https://utsouthwestern.influuent.utsystem.edu/en/publications/human-nci-h295-adrenocortical-carcinoma-cells-a-model-for-angiote"><LINK_TEXT text="https://utsouthwestern.influuent.utsyst ... or-angiote">https://utsouthwestern.influuent.utsystem.edu/en/publications/human-nci-h295-adrenocortical-carcinoma-cells-a-model-for-angiote</LINK_TEXT></URL></r>

 

[Shadow]

Re: CONNECTION LICORICE, INOSITOL, RU, ELLA, PROGESTERONE

<t>Damn! Since I started taking SSRI + bupropion my blood pressure spiked! I was put on an angiotensin-II inhibitor(losartan)</t>

 

[Helen]

Re: CONNECTION LICORICE, INOSITOL, RU, ELLA, PROGESTERONE

<t>You see there is an interesting connection with lithium also. Did anyone try lithium?</t>

 

[Shadow]

Re: CONNECTION LICORICE, INOSITOL, RU, ELLA, PROGESTERONE

<r>As far as I know, no.<br/>
A time ago I was trying to find a connection among the things that made people recover from pssd. Three of them are in this title!<br/>
Was reported recoveries from:<br/>
<br/>
Licorice + Kudzu(1 person)<br/>
<URL url="https://pssdlab.wordpress.com/ggggg123-licorice-root/"><s></s>https://pssdlab.wordpress.com/ggggg123-licorice-root/<e></e></URL><br/>
<br/>
Inositol(2 people)<br/>
<URL url="https://pssdlab.wordpress.com/pssd-inositol/"><s></s>https://pssdlab.wordpress.com/pssd-inositol/<e></e></URL><br/>
<URL url="https://pssdlab.wordpress.com/pharmd-inositol/"><s></s>https://pssdlab.wordpress.com/pharmd-inositol/<e></e></URL><br/>
Some minor improvements were reported too.<br/>
<br/>
St John's Wort(3 people)<br/>
<URL url="https://pssdlab.wordpress.com/kramdrol-st-johns-wort/"><s></s>https://pssdlab.wordpress.com/kramdrol-st-johns-wort/<e></e></URL><br/>
<URL url="https://pssdlab.wordpress.com/beetlebum-st-johns-wort/"><s></s>https://pssdlab.wordpress.com/beetlebum-st-johns-wort/<e></e></URL><br/>
One person on reddit recovered multiple times.<br/>
Temporary improvements were reported.<br/>
<br/>
Mianserin(1 person)<br/>
<URL url="https://pssdlab.wordpress.com/louis-syfer-mianserin/"><s></s>https://pssdlab.wordpress.com/louis-syfer-mianserin/<e></e></URL><br/>
<br/>
Low dose SSRI(1 person)<br/>
<URL url="https://pssdlab.wordpress.com/pete-low-dose-ssri/"><s></s>https://pssdlab.wordpress.com/pete-low-dose-ssri/<e></e></URL><br/>
I think that 2 other people reported some improvement.<br/>
<br/>
Then we have people on Ella, 1 recovered(Trondanac), expendable doing well.</r>

 

[Helen]

Re: CONNECTION LICORICE, INOSITOL, RU, ELLA, PROGESTERONE

<r><URL url="https://www.drugs.com/answers/lithium-libido-increased-anyone-issue-676767.html"><LINK_TEXT text="https://www.drugs.com/answers/lithium-l ... 76767.html">https://www.drugs.com/answers/lithium-libido-increased-anyone-issue-676767.html</LINK_TEXT></URL><br/>
<br/>
<URL url="https://www.psychforums.com/bipolar/topic127142.html">https://www.psychforums.com/bipolar/topic127142.html</URL><br/>
<br/>
Interesting.</r>

 

[Jaxx]

I dont recall pssd-people reporting improvements on lithium, but there was someone reporting mayor benefits on parnate(maoi). I had temporarily relief on moclobemide.

 

[Snell1234]

Re: CONNECTION LICORICE, INOSITOL, RU, ELLA, PROGESTERONE

<r><QUOTE author="gbolduev" post_id="2371" time="1508667794" user_id="90"><s>

</s>
<URL url="https://www.drugs.com/answers/lithium-libido-increased-anyone-issue-676767.html"><LINK_TEXT text="https://www.drugs.com/answers/lithium-l ... 76767.html">https://www.drugs.com/answers/lithium-libido-increased-anyone-issue-676767.html</LINK_TEXT></URL><br/>
<br/>
<URL url="https://www.psychforums.com/bipolar/topic127142.html">https://www.psychforums.com/bipolar/topic127142.html</URL><br/>
<br/>
Interesting.
<e>

</e></QUOTE>

Is lithium okay for pfs too?</r>

 

[expendable]

Re: CONNECTION LICORICE, INOSITOL, RU, ELLA, PROGESTERONE

<r><QUOTE author="Shadow" post_id="2363" time="1508664517" user_id="54"><s>

</s>
I read some nice info regarding of Inositol.<br/>

<QUOTE><s>

</s>Inositol is a vitamin-like nutrient generally obtained by eating fruits.<br/>
Inositol increases the potency of estrogens by enhancing the subcellular signal-transduction actions triggered by estrogen. (Interestingly, Vitamin C - a nutrient also obtained from fruits - may also enhance estrogen's production or effects.)<br/>
The brain determines how much testosterone to produce by measuring estrogen. Testosterone is the precursor for Estrogen. So increasing estrogen potency will reduce production of testosterone. This occurs both in men and women.<br/>
Too much Inositol can cause significant estrogenic adverse effects such as breast tenderness, breast growth, water retention, heavier menstrual flow, irritability and aggression.<br/>
Inositol is increased by antidepressant treatments and such an increase may be crucial for their effectiveness. Note that estrogen also has antidepressant effects - e.g. improving memory, motivation, competitiveness, drive. Estrogen acts in part as a monoamine oxidase inhibitor.<e>

</e></QUOTE>

<URL url="https://www.reddit.com/r/Nootropics/comments/4g0sn1/does_inositol_lower_testosterone_in_men/"><s></s><LINK_TEXT text="https://www.re...tol_lower_testosterone_in_men/</LINK_TEXT><e></e></URL>
<e>

</e></QUOTE>

vitamin C? JUICE FAAAAAAAAAAAAST</r>

 

[wuf]

Shit guys, there are so many things going on to try that I am getting confused. I mean, which one to try first and which are the risk correlated to each one?
I could even try them all, the only reason I don't is the fear of loosing ground and get worse in my baseline..

 

[expendable]

Shit guys, there are so many things going on to try that I am getting confused. I mean, which one to try first and which are the risk correlated to each one?
I could even try them all, the only reason I don't is the fear of loosing ground and get worse in my baseline..

take them all bro! licorice root, forskolin, boron, inositol, ru, ella, lithium, kudzu root, fish oil, multivit, zinc, l-arganine, l-tyrosine, gingko, maca, clomid stack. what could go wrong?

:lol:

 

[wuf]

Shit guys, there are so many things going on to try that I am getting confused. I mean, which one to try first and which are the risk correlated to each one?
I could even try them all, the only reason I don't is the fear of loosing ground and get worse in my baseline..

take them all bro! licorice root, forskolin, boron, inositol, ru, ella, lithium, kudzu root, fish oil, multivit, zinc, l-arganine, l-tyrosine, gingko, maca, clomid stack. what could go wrong?

:lol:

LOL

 

[IHateFin]

i too am just wrapping up week 2 of 18g of inositol. better mood, and better libido n such. it also tanks potassium which i can tell from the heart palps that it has caused me to have. i love this stuff and plan to be on it til the end of novenmber along with Randro.

 

[wuf]

i too am just wrapping up week 2 of 18g of inositol. better mood, and better libido n such. it also tanks potassium which i can tell from the heart palps that it has caused me to have. i love this stuff and plan to be on it til the end of novenmber along with Randro.

So, I have a question for all you guys cause I want to try something but I am seriously confused to where to start in my position.
I think my position is quite different from all yours, I mean, I have been there where you are with PFS since I am a long sufferer but with time I really got better sonce I had strong libido. So, I generally can sleep and all my symptoms are over I would say but now libido and sensitive dick is over.. but at the same time I can have 100% strong elections but with decreased sensitivite and decreased pleasure...at time even discomfort but still hard.
It seems like if in my brain something doesn't kick in.. just before to crash with dhea I was having so much feeling and pleasure.
Where would you start?
I accept all comments, thank you.
[mention]gbolduev[/mention]
I also used potassium, Nad, zinc,magnesium,b6 as gbold suggested from 10 days and I have started to go out again, to have more initiatives and mood...
Libido and sensitivity still down.
Plus, my estrogens are low since I dropped them with arimidex (I guess)...and also my sodium is low in hair..

 

[Shadow]

Shit guys, there are so many things going on to try that I am getting confused. I mean, which one to try first and which are the risk correlated to each one?
I could even try them all, the only reason I don't is the fear of loosing ground and get worse in my baseline..

take them all bro! licorice root, forskolin, boron, inositol, ru, ella, lithium, kudzu root, fish oil, multivit, zinc, l-arganine, l-tyrosine, gingko, maca, clomid stack. what could go wrong?

:lol:

Dont let [mention]IHateFin[/mention] read this! :lol: :lol: :lol:

 

[IHateFin]

Shit guys, there are so many things going on to try that I am getting confused. I mean, which one to try first and which are the risk correlated to each one?
I could even try them all, the only reason I don't is the fear of loosing ground and get worse in my baseline..

take them all bro! licorice root, forskolin, boron, inositol, ru, ella, lithium, kudzu root, fish oil, multivit, zinc, l-arganine, l-tyrosine, gingko, maca, clomid stack. what could go wrong?

:lol:

Dont let @IHateFin read this! :lol: :lol: :lol:

Dude don't get me tempted!! :lol:
I mean I have just about all of these items laying around. WHAT IF THATS THE CURE!? Haha jkjk

 

[expendable]

take them all bro! licorice root, forskolin, boron, inositol, ru, ella, lithium, kudzu root, fish oil, multivit, zinc, l-arganine, l-tyrosine, gingko, maca, clomid stack. what could go wrong?

:lol:

Dont let @IHateFin read this! :lol: :lol: :lol:

Dude don't get me tempted!! :lol:
I mean I have just about all of these items laying around. WHAT IF THATS THE CURE!? Haha jkjk

The hilarious irony is that, at out current level of understand, the cure probably does lie within that group of supps. Infuriatingly close!

EDIT: Oh yeah, what's the connection between this thread and your new theory IHateFin? Gbold is basically saying the same thing you did but without the part about DHT. Is the DHT really necessary here? Could it hurt? Why didn't gbold mention it? :?: