Noodle post_id=3298 time=1509639845 user_id=63 said:
Wow, if we are back to hitting RDA, you can stop taking zinc and all the other things too
Zinc + manganese was not supposed to be taken to get to daily RDA levels.
Its to go back
to some kind of balance.
Obviously, but getting excessive Mn through diet is very easy. Super easy to hit like 200% RDA. Zinc is another story - most people never get enough of it, especially men that ejaculate frequently (very easy for adequate intake to be as high as 20-30mg/day in some men).
The whole reason for Mn + Zinc is to restore SOD. Mn for MnSOD and Zn for CuZnSOD. But if your intake of Mn has been high for years (like most people), MnSOD is probably fine and won't need supplementing. Cu + Zn can be useful for people with both low copper and zinc, but many people have high copper, so only zinc is needed for CuZnSOD. It makes sense why some people would benefit most from Cu+Zn. Gbold always talked about Mn + Zinc because in his case he was high copper, he kept his carb intake low, and was fasting a lot, so Mn intake would be low. Most people don't really need excess Mn.
Anyways, healthy hair needs good amounts of bioavailable iron, methionine, and cysteine. This is a tall order, because in order for iron/met/cys, which are all capable of forming complex reactive species, you need to have their reactive precursors under control. This means increasing SOD activity without over-stimulating metabolism and it's downstream ROS production. You also need to chelate calcium, but chelating tisue calcium increases metabolism, again increasing ROS and driving down bioavailability of iron/met/cys. This is a tough problem to solve, and jamming the system with excess Mn won't solve it, since excess Mn inhibits calcium efflux (calcium chelation), and increases ROS formation.
The answer lies (I think) in first chelating calcium and iron for decalcification and to make iron more bioavailable. This will in turn lower end stage RS production and stabilize mitochondria. Then afterwards to increase SOD levels via Mn/Cu/Zn, and then finally to increase met/cys intake. I think doing that while stimulating hair growth physically (e.g. aggressive massage), particularly during the last phase, is the path to hair regrowth.