Fighting….

[bruschi11]

Ok my fluoride is really high right now. My fluoride really low. Relatively in terms of the average day.

For me. They’re very top and and very bottom.

It it simply fluoride taking down folate cycle so copper can be used?

It probably is. Like not much else: like such a simple disease.

I can’t feel copper much in my head at all. And I do think there is a reason for it.

Fluoride down. Folate up. Is the plan right now I guess.

 

[bruschi11]

it’s prob fluorides affects on ER just demands dht for the er to work.

The lower the fluoride level the lower the need for dht.

I like dht best of the 3 hormones dhea test dht I’ve been taking.

But I don’t even like taking dht. It makes me worse on it besides relaxation. Then better off. Iodine works well .

I almost feel like test is causing issues but it’s a non argument besides is the oral test better .

 

[bruschi11]

I’m thinking maybe epiandrosterone rather than 11 keto dht.

As epi has good track record in pfs. And is downstream from allo. So it can help retain allo im thinking.

Allo is gaba. The allo thing is real. I’ve had crazy effects with it.

It just seems the combo of dht and e2 production make estrogen work. But rest of system needs to catch up. Aldo turns on but we gotta get a way to get progesterone up so we can start retaining potassium.

As we show sodium raising in Oligos not potassium yet

 

[bruschi11]

e2 =b5 system iodine usage. Allowing Aldo to raise and thus sodium.

B6 system is about progesterone production. Which then allows potsssium electrolytes to raise . And then iron copper really come in this place.

Thing is… e2 needs dht to work.

 

[bruschi11]

This is random pretty out of nowhere. DHT suppressess ERb

"Furthermore, our recent studies have shown that suppression of estrogen receptor β (ERβ) and its target gene is associated with ASD development, while the expression of estrogen receptor α (ERα) has little correlation (Zou et al., 2017; Li et al., 2018; Xie et al., 2018), leading us to suppose that prenatal androgen exposure may induce ASD development through ERβ suppression."

Frontiers | Berberine Ameliorates Prenatal Dihydrotestosterone Exposure-Induced Autism-Like Behavior by Suppression of Androgen Receptor

Many epidemiology studies have shown that maternal polycystic ovary syndrome (PCOS) results in a greater risk of autism spectrum disorders (ASD) development,...

www.frontiersin.org

So basically I'm thinking. In PFS, we are on finasteride then we stop it. Stopping it is what really messes people up it seems.

We get a major DHT increase rapidly as the enzyme opens up.

3b-diol is what activates ERb though. So normally we would like DHT as it converts to 3b-diol. That is the problem here. We are not getting to 3-b-diol and we are stuck at dht as the excess DHT just shuts down that enzyme getting us to 3b-diol causing autism.

What is that enzyme now...... 3b-hsd. So DHT gets stuck.

While epiandro can get us to 3b-diol. Through 17b-hsd.

 

[bruschi11]

This is random pretty out of nowhere. DHT suppressess ERb

"Furthermore, our recent studies have shown that suppression of estrogen receptor β (ERβ) and its target gene is associated with ASD development, while the expression of estrogen receptor α (ERα) has little correlation (Zou et al., 2017; Li et al., 2018; Xie et al., 2018), leading us to suppose that prenatal androgen exposure may induce ASD development through ERβ suppression."

Frontiers | Berberine Ameliorates Prenatal Dihydrotestosterone Exposure-Induced Autism-Like Behavior by Suppression of Androgen Receptor

Many epidemiology studies have shown that maternal polycystic ovary syndrome (PCOS) results in a greater risk of autism spectrum disorders (ASD) development,...

www.frontiersin.org

So basically I'm thinking. In PFS, we are on finasteride then we stop it. Stopping it is what really messes people up it seems.

We get a major DHT increase rapidly as the enzyme opens up.

3b-diol is what activates ERb though. So normally we would like DHT as it converts to 3b-diol. That is the problem here. We are not getting to 3-b-diol and we are stuck at dht as the excess DHT just shuts down that enzyme getting us to 3b-diol causing autism.

What is that enzyme now...... 3b-hsd. So DHT gets stuck.

While epiandro can get us to 3b-diol. Through 17b-hsd.

This is why my pregnenolone went so high in PFS. Without 3b-hsd, can’t convert to preg to prog.

 

[bruschi11]

This is why my pregnenolone went so high in PFS. Without 3b-hsd, can’t convert to preg to prog.

Epiandro also pressures 3b-hsd. Not to get to 3b-diol. But to get to 5a-A-Dione. Bummer.

But it doesn’t inactivate ERb like dht does.

 

[bruschi11]

It’s not on this site cuz the last say 18 months of hack between 2020 and 2021 aren’t here.

But Gbold was talking about ER as in the estrogen receptor.

I’m sure he was onto what I’m saying. It’s all sooooooooo obvious.

Bh4 is the key to cortisol and thyroid. You need both. You can’t just go at thyroid with t3 or t4 you need bh4 running shit through tyrosine.

And that’s an estrogen driven enzyme.

Isn’t fair. 10 years of pfs in November. What a fucked up life for the stupidest of reasons. I could’ve cured this easily years ago if i knew.

I’ve had a dementia like disease for 2 years now. I will be very lucky if i can get out of this.

 

[zancek0]

For those that dont know... this site is missing quite a lot of late hackstasis content. During the period (which is missing on this site), Gbold was also active elsewhere. On raypeatforum under nickname (Fairplay - https://lowtoxinforum.com/search/2764889/?c[users]=Fairplay&o=relevance), on certain discord servers, esp Meso's PSSD server (some screenshots below), on russian poiscenter (Общее обсуждение POIS - Страница 1061 - POIS - синдром недомогания после оргазма - poiscenter.net --- another post relevant to what bruschi is saying re: ER).

 

[bruschi11]

For those that dont know... this site is missing quite a lot of late hackstasis content. During the period (which is missing on this site), Gbold was also active elsewhere. On raypeatforum under nickname (Fairplay - https://lowtoxinforum.com/search/2764889/?c[users]=Fairplay&o=relevance), on certain discord servers, esp Meso's PSSD server (some screenshots below), on russian poiscenter (Общее обсуждение POIS - Страница 1061 - POIS - синдром недомогания после оргазма - poiscenter.net --- another post relevant to what bruschi is saying re: ER).

Yea everything comes down this this I’m sure of it.

The damage tho. Like SOD can go down long term . B6 . The system being down as long as it has for me . It can easily be a too late situation. 10 fucking years of pfs.

I think testosterone with Epiandro. Or maybe some 4 andro with it. And iodine . Along with your support with k2 (to move estrogen) , ca/mg/zn b complex makes sense.

Test suspension was super strong today after putting epiandro in. Epiandro= 3b-diol=ERb.

When ERb turns on we need estrogen there and when e2 is received, aldosterone is raised.

Iodine moves T to e2. So you’ll see girls on iodine with low vanadium in hair as they aren’t doing anything for estrogen receptor. And you’ll literally see girls pushing iodine get pfs type illness.

So we wanna give some sort of T if we are low T. With iodine / inositol / b12 to get from T to E2. Then e2 needs to be received by ERb and epiandro for 3b-diol gets us there . We also need to move e2 to estrone and k2 gets us there.

I had high end e2 when my TRT failed in early winter. While on TRT. I just wonder if going on TRT and making sure I’m giving epiandro / 4 andro plenty, iodine etc if that will be ok.

Test suspension I just don’t know here. It seems like from bloodwork (I got back the other day of being on 4 days of test suspension w/ iodine) , my system turns on from iodine and my test drops so hard.

 

[bruschi11]

Yes epiandro is a whole different level than dht.

But it’s not when you take the epi. The epi made me worse. I took test suspension after and it hit me so freakin hard as the day went on and overnight.

 

[bruschi11]

End of day we cause VDR issues in pfs as we can’t use our estrogen which we all know is huge for VDR .

Phos comes up when VDR comes on converting FMN to FAD but demanding magnesium for sure. Demanding more zinc for b2 to fmn, potassium. Iodine. And selenium.

But the body can’t use selenium currently. That’s my problem. My sele is super high still. It’s not dropping. Same with lithium. Just not dropping.

And fluoride just isn’t going anywhere either. I like seeing fluoride 20%. It’s been around 30 and is 29 today. The highest it goes is around 35 I’ve seen 40.

But when I’m doing good things it’s generally between 20 and 25.

I’m thinking here fluoride went down on dht. Epi isn’t dht. But it helps make dht downstream. So maybe it’s actually better to raise dht slowly and not focus too hard on the fluoride cuz dht will just raise aldo beyond progesterone. As progesterone is the true way to the electrolyte being retained in the cell.

My bodies estrogen smell on epi is pretty amazing. Like this is what happens when e2 starts working for me . Where my body is making estrogen and using it. I knew it had something to do with e2 as soy used to do this.

Thinking about everything

Epi= FAD assuming e2 available. But fad may make mf but does not = folic acid. As folic continues to be my low vitamin. B6 ain’t great it’s ok. I don’t know where I’m missing here.

 

[bruschi11]

amino acids came back the worst they’ve ever been. Like really bad. My bloods last week were really really bad.

So I went on TRT again yesterday. It’s a lot right now but I’ve taken a lot of iodine and I’m thinking iodine is ERa. When we gotta get back to ERb which is the PFS problem (low 3b-diol).

I think iodine with an approach to keep 3b-diol and if needed test in low T cases might be the real way in pfs.

But I’m bad. Scary place bad.

 

[Yura]

@bruschi11 are you thinking that when you take hormones it it will work basically the opposite way like Helen was talking about?
I mean all those feedback loops while taking stuff. You take one hormone and basically everything changes. Impossible to track and somehow manipulate everything..

 

[bruschi11]

Iodine depletes folic acid with nadph for bh4. I think I’m making fad good and methylfolate should be fine.

I think this is where iodine really can bite you. My bloodwork was bad that I got back very bad. I was shutting myself down with test suspension and giving iodine and folic acid in my Oligoscans kept dropping.

It’s going back up now that I’m on TRT but thought spot

 

[bruschi11]

@bruschi11 are you thinking that when you take hormones it it will work basically the opposite way like Helen was talking about?
I mean all those feedback loops while taking stuff. You take one hormone and basically everything changes. Impossible to track and somehow manipulate everything..

I think you can supp hormones to run a metabolism which fixes the brain.

Where mindsets are really thyroid copper iron sulfur. Complex 1 3 and 4. Oxygen transport has to happen. And I think when you get ahold of these, complex 2 comes up (fad).

I think of hormones the same way people use biotin and egcg to dump iron and copper.

We are all just searching for a metabolism that gets the electron transport chain working in a strong way.

 

[bruschi11]

Yea ERb is basically it….

This is just on Wikipedia

“ERβ helps by up-regulating insulin-degrading enzyme (IDE), which leads to β-amyloid degradation when accumulation levels begin to rise. However, in AD, lack of ERβ causes a decrease in this degradation and an increase in plaque build-up.”

I have high insulin.

 

[zancek0]

My bodies estrogen smell on epi is pretty amazing.

So your body odour changes? Can you describe the difference?

 

[bruschi11]

I’m in a bad place. I gotta make some changes and give this all one last shot.

I’m on TRT and I hate it. It’s constant oxidation. Which I need. But it’s just tough on electrolytes like very much specifically when iodine and nutrients go in.

But if iodine and nutrients don’t go in the system dies .

Test is only a piece. It’s a supplier. It feeds estrogen. It keeps tyrosine afloat. Bh4 system. No need for coffee with test cuz it’s test that keeps tyrosine up. T4.

Iodine Carnitine inositol b12 raise nadph for T to E2. Now do we want to start giving epiandro and 4 andro? I’ve taken a few days off of these. I’m thinking so. I hope they can kind of save me like 4 andro/ dhea/ preg would at times last fall.

 

[RebelWithACause]

How does TRT provide oxidation? Just wondering