General Chat

[ruprmurdoch]

Iron and copper both get dis-regulated from toxic metals too unless you have some genetic thing like those men who retain a lot of iron because of a gene. I never felt better from getting rid of iron personally and focussing on that for example. It's the same how people chelate calcium even though if you would make your body work properly your body would use the calcium. Now you just take away a piece to have less problems.

Lead also causes high DHT for example. Same for mercury. Maybe even aluminum. Cadmium. That's why some people I think also feel better on 5ar inhibitors. Especially if they have normal NADPH production. If you don't then you feel like shit on finasteride and other 5ar inhibitors. Which was my case. I could not tolerate any 5ar inhibition even mild. Same for a lot of people from PropeciaHelp and cdsnuts I remember. They would feel worse on even coconut oil for example. They probably had low NADPH production and finasteride made it even lower and you get way too low DHT and with low libido, anxiety, etc.

Remember how Helen said he felt better when he used finasteride. He was/is lead toxic too heavily. So I think a lot of people have these problems but different core problems or other metals maybe. It shows you lead can also cause high DHT. Any other toxic metal that is close to iron or copper.

Could also be a reason why the body keeps NADPH and hormone production low in those people so they don't get problems with high DHT and calcification. In a way it is a healthy response.

I also met people who felt better on 5ar inhibitors like finasteride but probably took too much for too long and then you get the same problem as the guys who already had low NADPH to start with. Because the effect of finasteride lasts long. Finasteride and dutasteride are too strong in that case and useless long term. Especially if you use it like the average person.

For the guys with low NADPH they take finasteride and they are done. That's why some of them crashed after 1 pill. Helen explained this in detail too.

This is what I think at least and noticed in myself.

You never felt better from getting rid of iron personally, beacusse maybe You also have high Cu levels and You become estrogen dominant ? I know from myself that when I feel estrogen dominance I can take Iron and I am calm - beacuse DHT grow and this is connected to Gaba and this make You calm.
I think when you start simple chelatation of Fe, then You start feel Cu toxicity and feel kind a rage/agression. If I' m wrong let me know

 

[RebelWithACause]

You never felt better from getting rid of iron personally, beacusse maybe You also have high Cu levels and You become estrogen dominant ? I know from myself that when I feel estrogen dominance I can take Iron and I am calm - beacuse DHT grow and this is connected to Gaba and this make You calm.
I think when you start simple chelatation of Fe, then You start feel Cu toxicity and feel kind a rage/agression. If I' m wrong let me know

Probably different per person. I don't think iron chelation is a solution for my problem. Maybe for others it is. I never had these high iron problems. I used to think I did. But I have more opposite. Probably low iron absorption whole life, low steroids, etc. Probably from high toxic metal load from birth which causes dysregulation of those minerals and also can cause low NADPH so low hormones. Low testosterone you also absorp way less iron.

For others it might be a problem. Might have had normal iron absorption and normal hormones and on top of that mineral disregulation then it's probably a different story.

 

[highserotonin90]

"By the way, dexamethasone blocks cortisol receptors, causing cortisol levels to rise. This significantly reduces the sensitivity of progesterone receptors and also leads to a decrease in intracellular potassium levels. And if, for example, you gradually taper off dexamethasone—just as you would with Clomid—and in the meantime administer zinc and nicotinamide for 3-beta-HSD, then everything will start to unfold exactly as it does with progesterone or Clomid.

This post-progestin cycle is also suitable for treating post-finasteride syndrome. But it won’t be a walk in the park))

And you suffer from respiratory acidosis, since your progesterone receptors are very sensitive. It only takes a little zinc for your intracellular potassium to start fluctuating. (Progesterone raises potassium levels inside cells.) If the receptors are sensitive, potassium rises faster than necessary. The rise in intracellular potassium levels leads to an increase in CO₂ levels, since potassium accelerates metabolism. And there isn’t enough zinc to convert the CO₂ into bicarbonate, because as zinc levels rise, so do progesterone levels—which leads to an even greater increase in potassium levels. That is why, if you take zinc without manganese, respiratory problems can arise due to the high CO₂ level. Even when taking zinc together with manganese, sensitivity still decreases. The body is unable to absorb zinc, since progesterone receptor levels are high and zinc levels remain low. You see, the potassium level inside the cell should actually increase thanks to zinc, since zinc is able to raise the CO₂ level inside the cell and expel it outside the cell.

These methods likely work best for those who have taken steroids such as progestins, Propecia, asthma inhalers, and so on.
If there is a methylation abnormality, but at the same time low dopamine levels, a systemic problem will also arise, since estrogen receptors will be reduced due to prolactin, while progesterone receptors will be increased. That’s why methylation helps, in my opinion. It does the same thing as Clomid and all the other medications, except that, perhaps, it actually treats the person who specifically needs methylation. All other measures may be temporary for these individuals, since, for example, if you have low dopamine levels and have regulated your progesterone receptors with dexamethasone, the effect will fade away after a while anyway.

But the essence of POIS lies in the reduction of progesterone receptors.

Fasting works, too. If you fast, blood sugar drops, cortisol rises sharply, and the body suppresses progesterone receptors to slow down metabolism. The potassium level in the cells drops, and body temperature decreases. Eventually, you take zinc and other supplements. BOOM


No matter how you look at it, you’ll only take zinc in the event of complete failure. And it’s desirable for this failure to last a long time. That is, the longer you delay discontinuing dexamethasone or Clomid, the greater your zinc intake will be. Here, the duration itself and the gradual reduction of the dose are what really matter."


I found this on the Pois Center forum. I wanted to understand why dexamethasone would block the GRs. Doesn't it cause downregulation?