glucose 6 phosphatase enzyme problems in PFS for some cases.

[Helen]

I think it could be that in some people fin impaired this enzyme. And now glucose 6 phosphate is not converted to glucose. And thus glucose phosphate accumulates and goes into the pentose pathway and it activates it too much. ( so these people might make tons of NADPH) This causes too much creation of purines. and lactic acid.

And also it raises cortisol and keep it high, since you dont have glycogen access.

Also this might explain high testosterone and high DHT in people.



lets discuss this.

 

[Jaxx]

Would this be easy to see in a blood test?

 

[supernature]

Would this be easy to see in a blood test?

...

This causes too much creation of purines. and lactic acid.

...

 

[Helen]

Its a blood test that is done to identify G6PD gene issues, but it could be done to access its activity in a no mutation cases. Its deficiency should be seen as hemolytic anemia, low Hgb.




And maybe too much uric acid ?

Be careful. glucose 6 phosphatase is the enzyme that breaks down glucose phosphate into glucose. this is called glycogen storage disease. It is not G6PD enzyme

In this case glucose phosphate since it is not broken down into glucose accumulates and since it is the component of G6PD pentose. it activates it too much and you get high purines, high NADPH and NADPH oxidase creating tons of ROS, uric acid and also high alanine in the urine, and also high uric acid

But the actual problem in the insulin glucose 6 phosphatase romance. You cant use your glycogen stores. So your lactic acid goes up and also cortisol

but there are tons of cases in glycogen storage diseases. check them out.

I have read that biotin helps the condition, but does not cure it.

 

[supernature]

Be careful. glucose 6 phosphatase is the enzyme that breaks down glucose phosphate into glucose. this is called glycogen storage disease. It is not G6PD enzyme

In this case glucose phosphate since it is not broken down into glucose accumulates and since it is the component of G6PD pentose. it activates it too much and you get high purines, high NADPH and NADPH oxidase creating tons of ROS, uric acid and also high alanine in the urine, and also high uric acid

But the actual problem in the insulin glucose 6 phosphatase romance. You cant use your glycogen stores. So your lactic acid goes up and also cortisol

but there are tons of cases in glycogen storage diseases. check them out.

I have read that biotin helps the condition, but does not cure it.

...

 

[Slayo]

This may explain why in my HTMA sodium and potassium are very low but calcium and magnesium are in range, and not high, strange slow oxidoser pattner as we should see high calcium and magnesium with sodium and potassium so low, and the fact that they aren't high may be because of lactic acid