Levonorgestrel

[Jaxx]

On the PSSD forum one user is trying levonorgestrel, with positive results so-far. Would be interesting tif anyone of the PFS community ever heard of others trying this.
As i understand this is a progesterone agonist.

PSSD Collaborative Research • View topic - Levonorgestrel


by johncriton » Sun Feb 25, 2018 8:08 pm

"Hello everyone. Ive been lurking on this site for some time now and tried to join awhile ago but couldnt but recently found out that restriction is no longer there so i just joined. Ive been trying out various supplements and drug that have been suggested mostly to no avail. But recently I hot my progesterone checked out as was suggested and I found out mine is on the higher end at 0.95ng/ml. So I tried the drug plan b out if desperation and Im amazed by its effects. Ive got morning wood again, my libido is up, my sensitivity is up as well as my orgasim pleasure. Its amazing! im not sure how long it well last but this is the first time that the result of taking something was this dramatic. It may not work for you but I think you should try it.

I take 1 pill everyday. I've been taking them for about 3 days now and feel better than I have in years. Im going to stop after 1 week total use. Will report if anything new happens before my trial use of plan b is over. Fingers crossed it doesnt wear off afterwards. You guys should try it too. You can pick it up at your local pharmacy without a script from a doctor."

 

[MNK99]

I've read it and thought about it but went to ella and ru instead, bc of success on here and pssd forum. If this helps and it's OTC in Canada, I may try it in the future, hopefully I won't need to. It's a progestin. I think it could be worth a shot and would buy it if I had easy access. The other pills seem more effective as abortive medicines.

http://www.gynecologiconcology-online.net/article/S0090-8258(05)00936-4/abstract

Conclusion:
The present study shows that LNG IUD causes an almost complete down-regulation (lack of immunohistochemical expression) of PR expression and a considerable down-regulation of ER expression in both glands and stroma. The changes in receptor expression were markedly less pronounced after treatment with intermittent oral MPA. The differences in receptor expression among responders and non-responders might serve as possible markers for therapy response.

Plasma progesterone levels during long-term treatment with levonorgestrel silastic implants
Abstract.
Plasma progesterone levels were measured in 113 women using a subdermal implant containing 200 mg levonorgestrel (NORPLANT™*) in an attempt to assess the roles of anovulation and inadequate luteal function in the contraceptive action of this method. Twenty-two women using an IUD (Copper T 200) served as a control group.

Blood samples were taken twice a week for 6 consecutive weeks. This was done one to four times in each subject during the first 7 years after insertion of NORPLANT. Plasma progesterone was measured by a specific RIA and criteria based upon normal values in this laboratory were used to define each set of samples as ovulatory, uncertain or anovulatory. Rate of anovulation varied 25-80%, highest rate seen after first yr.

These results clearly show that continuous administration of levonorgestrel by means of NORPLANT interferes with ovulation and/or luteal function in a significant proportion of cycles throughout the first 7 years of use.

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I think it lowers PR sensitivity. But of course it's used in gynecology for among other things ending pregnancy. Supposedly the other 2 are more effective at terminating pregnancy... and I'd estimate decreasing progesterone receptor sensitivity. It could be a good option for those of us who cannot find/afford the other 2.

https://scholar.google.ca/scholar?hl=en&as_sdt=0,5&q="levonorgestrel"+++"progesterone+sensitivity"&btnG=

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Here's a study discussing all three:

Emergency contraception: potential role of ulipristal acetate

I think that bc that UPA (ulipristal acetate/ ellaone) and MIfe are emergency contraceptives (EC), they'd be stronger. Obviously not much studies if any in men, besides the couple posted on HTPA and mood regulation of ru486.

Conclusion and recommendations
Emergency contraception is the only method that women can use after having sexual intercourse without contraceptive protection to avoid becoming pregnant. It could be a powerful means to prevent unwanted pregnancies if widely available and acceptable.
UPA is a first-in-class progesterone receptor modulator specifically developed for EC. It has been demonstrated to be highly efficacious versus LNG for intake within 24 hours as well as for intake up to 72 hours after unprotected intercourse. Furthermore, UPA maintains its efficacy up to 5 days after unprotected intercourse, matching the survival time of sperms. UPA 30 mg is as well-tolerated as LNG. Therefore UPA represents a veritable breakthrough in emergency contraceptive technology with a clear-cut medical advantage over LNG.
Although the main mechanism of action of both LNG and UPA is preventing follicular rupture and ovulation (Figure 3), the ‘window of effect’ for LNG seems to be rather narrow, beginning after selection of the dominant follicle, and ending when LH begins to rise. In contrast, UPA has been demonstrated to have a direct inhibitory effect on follicular rupture. This allows UPA to be effective even when administered shortly before ovulation when the LH surge has already started to rise, a time period when use of LNG is no longer effective. The differences in mechanisms of action explain the higher efficacy demonstrated for UPA to prevent pregnancy for both early and late use of EC. UPA may not be the first line EC for all users of hormonal contraceptives, since it increases their vulnerability to pregnancy significantly for the rest of the cycle. However, if users are willing to use back up barrier contraception until the next menses, UPA should be recommended.

 

[Jaxx]

A very promosing update on the pssd forum:

by johncriton » Sat Mar 10, 2018 11:05 am

As promised Im here to report on my progress ~1 week after stopping my plan b treatment. I continue to maintain improvement in every category like libido, sensitivity, orgasm pleasure, ect. Its absolutely amazing!!! Ill report back in another week or so. In the meantime you guys should try it yourself, even if its temporary its totally worth it to feel normal again.