Opiates & PFS Side Effects

[djohn051]

I've recently had an accident and have been prescribed opiates for pain management. What I have noticed is a massive spike in my libido, relative to 0% libido for 2 years. I had presented my test results on here a few weeks ago which shows that I had prolactin at around 17 points. Due to the known effect of opiates on dopamine and subsequent effect on prolactin, have I found a potential target for my libido issues? What are my options that don't require me to take narcotics?

 

[noprop]

Very interesting.
What about letting the body produce the own opiates by doing sports?
Of course, hurting yourself would increase the amount of endorphins massively but can't be a longtime solution.
I am trying the last method anyway to report back.

 

[djohn051]

Very interesting.
What about letting the body produce the own opiates by doing sports?
Of course, hurting yourself would increase the amount of endorphins massively but can't be a longtime solution.
I am trying the last method anyway to report back.

I have been boxing and hitting heavy weights for as long as I have had PFS. Unfortunately, never once has that done anything for my sexual side effects. When I took this medication (Oxycodone), I had that surge in sexual feeling and had the first spontaneous erection that I've had in years.

 

[noprop]

I have been boxing and hitting heavy weights for as long as I have had PFS. Unfortunately, never once has that done anything for my sexual side effects. When I took this medication (Oxycodone), I had that surge in sexual feeling and had the first spontaneous erection that I've had in years.

Wow, very cool, congrats. I am gonna research that stuff. How did you get that prescribed?

 

[Helen]

I have been boxing and hitting heavy weights for as long as I have had PFS. Unfortunately, never once has that done anything for my sexual side effects. When I took this medication (Oxycodone), I had that surge in sexual feeling and had the first spontaneous erection that I've had in years.

YOu can always try LDN to upregulate your opiod system

 

[TubZy]

I have been boxing and hitting heavy weights for as long as I have had PFS. Unfortunately, never once has that done anything for my sexual side effects. When I took this medication (Oxycodone), I had that surge in sexual feeling and had the first spontaneous erection that I've had in years.

Yeah, opiates increase 5AR and lowers test but not sure through what mechanism (maybe raising prolactin??)
In vivo evidence for an increase in 5alpha-reductase activity in the rat central nervous system following morphine exposure - ScienceDirect

 

[supernature]

I have been boxing and hitting heavy weights for as long as I have had PFS. Unfortunately, never once has that done anything for my sexual side effects. When I took this medication (Oxycodone), I had that surge in sexual feeling and had the first spontaneous erection that I've had in years.

...

 

[djohn051]

I am not at all trying to suggest using opiates to treat PFS. I have had close friends die from drug addiction. I merely posted it because not once in two years have I felt as good sexually as I did with this and am trying to understand the mechanism.

 

[djohn051]

Yeah, opiates increase 5AR and lowers test but not sure through what mechanism (maybe raising prolactin??)
In vivo evidence for an increase in 5alpha-reductase activity in the rat central nervous system following morphine exposure - ScienceDirect

Wouldn't it be more likely that it lowered my prolactin? Like I said, my prolactin was around 17 the last time I had it tested, so my thinking was that a surge in DA was lowering my prolactin and possibly increasing my feelings of sexuality.

 

[IHateFin]

Opiates would be just a bandaid and no way to cure this from that stuff. I guess you could just use them right before a date haha but def not long term or to cure anything..

 

[djohn051]

Opiates would be just a bandaid and no way to cure this from that stuff. I guess you could just use them right before a date haha but def not long term or to cure anything..

Would that likely be the case for any intervention that lowers my elevated prolactin?

 

[IHateFin]

Would that likely be the case for any intervention that lowers my elevated prolactin?

Well a lot of ppl who use trenbolone and need to reduce sides use caber or vitamin b6 pyridoxine HCL (not activated p5p) with great success.
I experimented with 200mg b6 and it did increase my libido and made my dreams stupid vivid haha was cool. I don't have much of a prolactin issue so the libido change was minor, but for you 200 to 300mg b6 may heavily increase your sex drive

 

[TubZy]

Wouldn't it be more likely that it lowered my prolactin? Like I said, my prolactin was around 17 the last time I had it tested, so my thinking was that a surge in DA was lowering my prolactin and possibly increasing my feelings of sexuality.

I doubt it everything I've seen on opiates seems to raise prolactin,
The effects of opiate agonists on growth hormone and prolactin release in rats. - PubMed - NCBI

 

[Walker]

I doubt it everything I've seen on opiates seems to raise prolactin,
The effects of opiate agonists on growth hormone and prolactin release in rats. - PubMed - NCBI

Can attest to this. As someone who has always been very sensitive to prolactin in the libido department, pre-PFS, during, and now since recovering, if I take opioids, my libido is always lowered.

 

[supernature]

I am not at all trying to suggest using opiates to treat PFS. I have had close friends die from drug addiction. I merely posted it because not once in two years have I felt as good sexually as I did with this and am trying to understand the mechanism.

...

 

[jacknap]

Yeah, opiates increase 5AR and lowers test but not sure through what mechanism (maybe raising prolactin??)
In vivo evidence for an increase in 5alpha-reductase activity in the rat central nervous system following morphine exposure - ScienceDirect

the black tar heroin protocol lol

 

[jacknap]

Can attest to this. As someone who has always been very sensitive to prolactin in the libido department, pre-PFS, during, and now since recovering, if I take opioids, my libido is always lowered.

not sure if kratom is considered an opiate but kratom nuked my libido same as my ru58841 crash. I was doing kratom lifestyle in which I would rotate strains for 2 weeks and took 2 weeks for my libido to come back and it snap backed better than before then leveled out.

similarly with ru58841swing back higher but then lowered to a crash (also had a ball pain and headache which I didn't have during the kratom swings)

 

[MNK99]

During / after surgery... serious double vision, possibly more urological burning and shrinakage, when taking opiates. --ONLY TIME EVER maybe after some other minor surgery, or breaking a bone... but always usually said : "No pain killers needed", in minor incidents. Possibly darkened night vision/peripheral vision too at the time.
-Definitely felt dumber also.

-Anyone ever try straight Opium? Just curious.

-Percocet many yrs ago... basically did nothing, tiny tiny buzz MAYBE.
-Please don't get me wrong, obviously I will not start experimenting with opium, simply a curious mind.

Pure Opium Work Niles? What About Vicodin? Dr. House used it -- he was fine, he handled responsibilities and was a great doctor (kind of a dick at times, but still).

@IHateFin: LDN VS. OPIUM VS. VICODIN??? @JUSTQUITDUT (I know you're somewhere out their bro...)

 

[Niles]

Just thought of this, but your improvements on opiates may have to do with the histamine release. Maybe you're low histamine - try active b6 and histadine and see if it helps.

 

[Grambo]

I have been boxing and hitting heavy weights for as long as I have had PFS. Unfortunately, never once has that done anything for my sexual side effects. When I took this medication (Oxycodone), I had that surge in sexual feeling and had the first spontaneous erection that I've had in years.

I had a very similar experience this past December. It was so good, that I've been trying to think of a way to cycle it ever since. I don't get addicted to things for some reason and have an open script, so I'm thinking it could work as a crutch. Maybe every other day?, every second day?, weekends only?, I don't know. Have you experimented anymore with it?