PFS and immune connection

[BeLikeWater]

Here are some facts:

- Lots of people with PFS seem to not have the flu with fever when they had it nearly every year before PFS.
- Some people have recovered from Brain Synptoms taking Hidrocortisone or similar.
- Vitamin D and inmune System is related:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166406/
- 5ar1 defiencie linkes to diabetes and poor use of insuline ( low energy )
http://diabetes.diabetesjournals.org/content/diabetes/64/2/447.full.pdf
- Dr. Melcagi directed us to low CNS 5ar metabolites in PFS users (5ar metabolites are created by 5ar1)
- Inactivation of inmune system enhance 5ar1 activity
- 5ar1 is in the brain and in charge of creation of neurosteroids?
- Low Dose Naxtrolone, initially used to treat inflammation in the body has been used in pfs with success, is an anti-opiod compound that is used during the night to upregulated endoopioid receptors, opiods increase 5ar activity in CNS.
- High Testosterone/DHT in blood has an inhibit action on 5ar1 on the brain ( thats why maybe people get worse with exogenous T and DHT).
- 5AR reduced glucocorticoids have a role to reduce inflamation.

Wha are your ideas about these facts?

 

[Helen]

Re: PFS and inmune connection

<t>In any case. I tested most of it, so I guess I can post here. Fin acts a progestin as we assumed correctly. Now the crash from fin and not ability to snap back is because there is a conflict between progesterone and cortisol created by fin. Basically after you get off fin, you have high progesterone and high cortisol and lowered 5 alpha reductase 2. Cortisol gets metabolized by 5 alpha reductase 2 , progesterone also. So you get stuck with high progesterone and high cortisol after fin. It should never be the case. Since progesterone should go high , cortisol low, cortisol high progesterone low. Since they regulate potassium in the cell.<br/>
<br/>
<br/>
In any case. when you take FIN it does indirectly inhibit 5 alpha reductase 2 by acting on progesterone and cortisol receptors.<br/>
<br/>
After you quit fin. You have high progesterone and high cortisol. And low acitivity of 5 alpha reductase 2. The reason why it does not snap back, since progesterone keeps retaining potassium and potassium stays high in the cell. Cortisol is keeping retaining sodium and causing alkalosis which puts potassium even higher in the cell and this puts a huge pressure on cortisol.<br/>
<br/>
5 alpha reductase 2 is what lowers cortisol. And it cant snap back, since cortisol is needed greatly at the moment.<br/>
<br/>
So the body is stuck. It cant increase 5 alpha reductase 2. And thus cortisol goes to cortisone excessively. This lowers insulin secretion to very low since cortisone lowers insulin in the body. And you are diabetic. <br/>
<br/>
So this is the my case. I am a case with low insulin. Fin has made be diabetic. <br/>
<br/>
Zinc is lost in the urine like crazy now. and iron stays in the liver. Since body thinks I have tons of progesterone and tons of cortisol. DHEA grows since zinc is going away.<br/>
<br/>
<br/>
So now I will break this loop by tanking potassium in the cell. tanking sodium in the cell. And forcing cortisol up by blocking <br/>
cortisol to cortisone converison, which will increase my insulin back to normal. Without insulin back to normal, All my attempts to increase zinc will be met with castration since zinc will increases progesterone which will retain more potassium which will increase metabolism and puts more pressure on cortisol which will lower 5 alpha reductase even lower. since 5 alpha reductase metabolizes cortisol.<br/>
<br/>
In this case , I will make my body have low potassium in the cell, and create increased cortisol( since I will stop cortisone conversion). Since increased cortisol should never exist with low cell potassium, body will have no other way to proceed but to upregulate 5 alpha reductase 2 to fight fatty liver and convert excessive cortisol . And I will get fixed from all these effects. Basically I will lower potassium, block cortisone , and force body to upregulate 5 alpha reductase 2</t>

 

[Helen]

Re: PFS and inmune connection

<t>I fixed this within a week. I think you are the same low insulin case</t>

 

[Canari]

Re: PFS and inmune connection

<r><MENTION><s>[mention]</s>BeLikeWater<e>[/mention]</e></MENTION> Very good job at gathering all these details and many facts!<br/>
<br/>
The only thing I can say is that anything that put a strain on the body fatigue the nervous system, and the nervous system influence the immune system. Your immune system can work only when you are in a rest and digest state = parasympathetic. That might explain you noticed a weakness of the immune system before crash.</r>

 

[Shadow]

Re: PFS and inmune connection

<r><MENTION><s>[mention]</s>gbolduev<e>[/mention]</e></MENTION> interesting that you mentioned that DHEA goes up, my blood test showed high progesterone and dhea, also high insulin(I had it high for a good amount of time, I eat too much(a lot) carb+sugar), but im pssd, maybe some things are different.</r>

 

[namaste]

Re: PFS and inmune connection

<r><QUOTE author="gbolduev" post_id="4365" time="1510875328" user_id="90"><s>

</s>
In any case. I tested most of it, so I guess I can post here. Fin acts a progestin as we assumed correctly. Now the crash from fin and not ability to snap back is because there is a conflict between progesterone and cortisol created by fin. Basically after you get off fin, you have high progesterone and high cortisol and lowered 5 alpha reductase 2. Cortisol gets metabolized by 5 alpha reductase 2 , progesterone also. So you get stuck with high progesterone and high cortisol after fin. It should never be the case. Since progesterone should go high , cortisol low, cortisol high progesterone low. Since they regulate potassium in the cell.<br/>
<br/>
<br/>
In any case. when you take FIN it does indirectly inhibit 5 alpha reductase 2 by acting on progesterone and cortisol receptors.<br/>
<br/>
After you quit fin. You have high progesterone and high cortisol. And low acitivity of 5 alpha reductase 2. The reason why it does not snap back, since progesterone keeps retaining potassium and potassium stays high in the cell. Cortisol is keeping retaining sodium and causing alkalosis which puts potassium even higher in the cell and this puts a huge pressure on cortisol.<br/>
<br/>
5 alpha reductase 2 is what lowers cortisol. And it cant snap back, since cortisol is needed greatly at the moment.<br/>
<br/>
So the body is stuck. It cant increase 5 alpha reductase 2. And thus cortisol goes to cortisone excessively. This lowers insulin secretion to very low since cortisone lowers insulin in the body. And you are diabetic. <br/>
<br/>
So this is the my case. I am a case with low insulin. Fin has made be diabetic. <br/>
<br/>
Zinc is lost in the urine like crazy now. and iron stays in the liver. Since body thinks I have tons of progesterone and tons of cortisol. DHEA grows since zinc is going away.<br/>
<br/>
<br/>
So now I will break this loop by tanking potassium in the cell. tanking sodium in the cell. And forcing cortisol up by blocking <br/>
cortisol to cortisone converison, which will increase my insulin back to normal. Without insulin back to normal, All my attempts to increase zinc will be met with castration since zinc will increases progesterone which will retain more potassium which will increase metabolism and puts more pressure on cortisol which will lower 5 alpha reductase even lower. since 5 alpha reductase metabolizes cortisol.<br/>
<br/>
In this case , I will make my body have low potassium in the cell, and create increased cortisol( since I will stop cortisone conversion). Since increased cortisol should never exist with low cell potassium, body will have no other way to proceed but to upregulate 5 alpha reductase 2 to fight fatty liver and convert excessive cortisol . And I will get fixed from all these effects. Basically I will lower potassium, block cortisone , and force body to upregulate 5 alpha reductase 2
<e>

</e></QUOTE>

Do you think PSSD has a similar mechanism?</r>

 

[expendable]

Re: PFS and inmune connection

<t>Does taking potassium reduce potassium in the cell? How's that work?</t>

 

[5 alpha]

Re: PFS and inmune connection

<r><QUOTE author="gbolduev" post_id="4366" time="1510875391" user_id="90"><s>

</s>
I fixed this within a week. I think you are the same low insulin case
<e>

</e></QUOTE>

Did you do this protocol personally recently?</r>

 

[vicecaz]

Re: PFS and inmune connection

<t>Interesting theory regarding insulin with PFS<br/>
<br/>
Before I took accutane, food with high glycemic index ( white bread, white rice, beer, banana, cooked carrots etc ) would make me break out and give me pimples, by triggering an insulin spike in my blood. A few minutes after eating them I would feel like an itch located where the acne flares up. Carbs like white rice would trigger the itch in my skin while low IG carbs like quinoa never did. <br/>
<br/>
After accutane and when all the symptoms arrived, the itch after eating those foods never happened again. Even after eating load of those, meaning I'm probably insulin resistant now, and I definitely agree with gbol theory on this. At least in my case</t>

 

[BeLikeWater]

Re: PFS and inmune connection

<t>Can we relate to the thread theme dont interfere.<br/>
<br/>
For example take exogenous test or increase DHT with things like Sorghum end up with better 5arw activity (better sebum) but feeling worse mentally, brain fog, etc... Seems the key here is upgrade 5ar1 activity to have DHT in brain, allo, etc...</t>

 

[Helen]

Re: PFS and inmune connection

<QUOTE author="BeLikeWater" post_id="4401" time="1510913047" user_id="112"><s>

</s>
Can we relate to the thread theme dont interfere.

For example take exogenous test or increase DHT with things like Sorghum end up with better 5arw activity (better sebum) but feeling worse mentally, brain fog, etc... Seems the key here is upgrade 5ar1 activity to have DHT in brain, allo, etc...

This is related to this thread and immune response. PFS puts you into alkalosis and this does not allow immune response to happen. Usually when you get sick, you go into acidosis. In PFS you cant do it. And thus you are getting chronic infections, which when you start fixing alkalosis you will FEEL so much it is not even funny. You will be sick big time.

taking exogenous test or DHT causes you to downregulate 3 beta hsd and 450scc. Which is already downregulated. thus your iron is not being used HENCE no immune response.

Same happens with POIS people. when POIS people get sick, their pois disappears. they dont get sick often since they are in alkalosis. In alkalosis there is no immune response. And when you have flu body tries to go into acidosis , which lowers cortisol since acidosis tanks potassium in the cell. When potassium is tanked , cortisol needs to be broken down. and it is broken down by 5 alpha reductase 2. Thus its activity goes UP and most PFS and POIS symptoms disappear. The only problem is this will raise progesterone requirement and wont allow 5 alpha reductase to go online fully. Thus you need to create an environment when both progesterone and cortisol ARE NOT NEEDED. only this will put 5 alpha reductase back online.

Taking cortisol tanks immune system. And increases 5 alpha reducates 2. since it is needed to break down cortisol and progesterone into it metabolites.


taking high dose progesterone or dexamethasone at the same time would force the body to upregulate 5 alpha reductase 2.

But it is much easier to do the same with mineral route which I outlined.

Copper keep thyroid low, while you increase potassium. This will allow both cortisol and progesterone to come down. And this will allow upregulation of 5 alpha reducate 2

Bottom line. Finasteride blocks 5 alpha reductase 2. this happens since finasterid is progestine which effects both cortisol and progesterone. this causes the unsolvable alkalotic discrepancy between cortisol and progesterone.


Cortisol lowers potassium in the cell, progesterone increases potassium in the cell. HERE you have both high progesterone and high cortisol . And cortisol cant come down, since progesterone is retaining the potassium. And progesterone cant come down, since 5 alpha reductase 2 is down. 5 alpha reductase 2 cant go back up, since cortisol is needed, since potassium is sky high in the cell, because of alkalosis.

You see the mechanism here.

To break this mechanism. you need to create an environment when both cortisol and progesterone are satisfied.

Progesterone is satisfied by potassium. Cortisol is satisfied by lower metabolism( copper) Mangesium gets rid of sodium retention which cortisol caused. B2 lowers serotonin



INSULIN will go up , only when progesterone COMES DOWN. Since high progesterone signal the body potassium deficiency, and in potassium deficiency insulin secretion will be ZERO. Since insulin puts potassium in the CELL.


PROGESTERONE causes INSULIN TO BE ZERO and actually causes FRANK DIABETES.

<URL url="Progesterone receptor knockout mice have an improved glucose homeostasis secondary to β-cell proliferation">Progesterone receptor knockout mice have an improved glucose homeostasis secondary to β-cell proliferation</URL>

RU486 reverses this.

But progesterone is raised in the body when potassium is deficient. Thus you better off take the mineral route that I outlined

 

[barbaar]

Re: PFS and inmune connection

<r><QUOTE author="gbolduev"><s>

</s>
Same happens with POIS people. when POIS people get sick, their pois disappears. This happens since body goes into acidosis, which lowers cortisol since acidosis tanks potassium in the cell.
<e>

</e></QUOTE>

Interesting. I'm PSSD, but last time I was sick with strep throat my emotions came back for a few moments. I also didn't eat for a few days, and took diclofenac + paracetamol (it was pretty bad lol, couldn't even drink water otherwise) so that might have something to do with it, but still, there might be a connection.</r>

 

[TubZy]

Re: PFS and inmune connection

<r><QUOTE author="gbolduev" post_id="4402" time="1510915322" user_id="90"><s>

</s>
<QUOTE author="BeLikeWater" post_id="4401" time="1510913047" user_id="112"><s>

</s>
Can we relate to the thread theme dont interfere.<br/>
<br/>
For example take exogenous test or increase DHT with things like Sorghum end up with better 5arw activity (better sebum) but feeling worse mentally, brain fog, etc... Seems the key here is upgrade 5ar1 activity to have DHT in brain, allo, etc...
<e>

</e></QUOTE>

<br/>
This is related to this thread and immune response. PFS puts you into alkalosis and this does not allow immune response to happen. Usually when you get sick, you go into acidosis. In PFS you cant do it. And thus you are getting chronic infections, which when you start fixing alkalosis you will FEEL so much it is not even funny. You will be sick big time.<br/>
<br/>
taking exogenous test or DHT causes you to downregulate 3 beta hsd and 450scc. Which is already downregulated. thus your iron is not being used HENCE no immune response.<br/>
<br/>
Same happens with POIS people. when POIS people get sick, their pois disappears. they dont get sick often since they are in alkalosis. In alkalosis there is no immune response. And when you have flu body tries to go into acidosis , which lowers cortisol since acidosis tanks potassium in the cell. When potassium is tanked , cortisol needs to be broken down. and it is broken down by 5 alpha reductase 2. Thus its activity goes UP and most PFS and POIS symptoms disappear. The only problem is this will raise progesterone requirement and wont allow 5 alpha reductase to go online fully. Thus you need to create an environment when both progesterone and cortisol ARE NOT NEEDED. only this will put 5 alpha reductase back online.<br/>
<br/>
Taking cortisol tanks immune system. And increases 5 alpha reducates 2. since it is needed to break down cortisol and progesterone into it metabolites.<br/>
<br/>
<br/>
taking high dose progesterone or dexamethasone at the same time would force the body to upregulate 5 alpha reductase 2.<br/>
<br/>
But it is much easier to do the same with mineral route which I outlined<br/>
<br/>
Copper keep thyroid low, while you increase potassium. This will allow both cortisol and progesterone to come down. And this will allow upregulation of 5 alpha reducate 2<br/>
<br/>
<br/>
<br/>
Bottom line. Finasteride blocks 5 alpha reductase 2. this happens since finasterid is progestine which effects both cortisol and progesterone. this causes the unsolvable alkalotic discrepancy between cortisol and progesterone.<br/>
<br/>
<br/>
Cortisol lowers potassium in the cell, progesterone increases potassium in the cell. HERE you have both high progesterone and high cortisol . And cortisol cant come down, since progesterone is retaining the potassium. And progesterone cant come down, since 5 alpha reductase 2 is down. 5 alpha reductase 2 cant go back up, since cortisol is needed, since potassium is sky high in the cell, because of alkalosis.<br/>
<br/>
You see the mechanism here. <br/>
<br/>
To break this mechanism. you need to create an environment when both cortisol and progesterone are satisfied.<br/>
<br/>
Progesterone is satisfied by potassium. Cortisol is satisfied by lower metabolism( copper) Mangesium gets rid of sodium retention which cortisol caused. B2 lowers serotonin<br/>
<br/>
<br/>
<br/>
INSULIN will go up , only when progesterone COMES DOWN. Since high progesterone signal the body potassium deficiency, and in potassium deficiency insulin secretion will be ZERO. Since insulin puts potassium in the CELL.<br/>
<br/>
<br/>
PROGESTERONE causes INSULIN TO BE ZERO and actually causes FRANK DIABETES.<br/>
<br/>
<URL url="http://www.pnas.org/content/99/24/15644.full">http://www.pnas.org/content/99/24/15644.full</URL> <br/>
<br/>
RU486 reverses this.<br/>
<br/>
<br/>
But progesterone is raised in the body when potassium is deficient. Thus you better off take the mineral route that I outlined
<e>

</e></QUOTE>

exercising while in fasted state or fasting plus high dose progesterone is another way right</r>

 

[dante]

Re: PFS and inmune connection

<r><QUOTE author="gbolduev" post_id="4402" time="1510915322" user_id="90"><s>

</s>
INSULIN will go up , only when progesterone COMES DOWN. Since high progesterone signal the body potassium deficiency, and in potassium deficiency insulin secretion will be ZERO. Since insulin puts potassium in the CELL.<br/>
<br/>
PROGESTERONE causes INSULIN TO BE ZERO and actually causes FRANK DIABETES.<br/>
<URL url="http://www.pnas.org/content/99/24/15644.full">http://www.pnas.org/content/99/24/15644.full</URL> <br/>

<e>

</e></QUOTE>
Have a doubt here(sorry for the digression )
<QUOTE><s>

</s> Since high progesterone signal the body potassium deficiency<e>

</e></QUOTE>
I thought high progestrone signals potassium retention while potassium deficiency signals progestrone secretion in order to retain K right ! That means for a normal healthy dude , exogenous progestrone might cause hyperkalemia due to kidneys retaining potassium and excreting sodium ( may be that's why the people at RPF crowd taking exogenous prog crave salt so much ), why will the insulin go down in this case since there is ample serum K ? Besides , the paper you linked is about mutant mice with gestastional diabetes. <br/>
I can link a paper here and say<br/>
<URL url="https://www.ncbi.nlm.nih.gov/pubmed/7039319">https://www.ncbi.nlm.nih.gov/pubmed/7039319</URL><br/>
Quoting from the paper - <br/>
"<I><s></s>This steroid induces <B><s></s>hyperinsulinemia<e></e></B><e></e></I>, possibly by direct action on pancreatic islets, while promoting glycogen storage in the liver. Paradoxically, it antagonizes the effects of insulin on glucose metabolism in adipose tissue and skeletal muscle "</r>

 

[Helen]

Re: PFS and inmune connection

<r><QUOTE author="dante" post_id="4412" time="1510924790" user_id="109"><s>

</s>
<QUOTE author="gbolduev" post_id="4402" time="1510915322" user_id="90"><s>

</s>
INSULIN will go up , only when progesterone COMES DOWN. Since high progesterone signal the body potassium deficiency, and in potassium deficiency insulin secretion will be ZERO. Since insulin puts potassium in the CELL.<br/>
<br/>
PROGESTERONE causes INSULIN TO BE ZERO and actually causes FRANK DIABETES.<br/>
<URL url="http://www.pnas.org/content/99/24/15644.full">http://www.pnas.org/content/99/24/15644.full</URL> <br/>

<e>

</e></QUOTE>
Have a doubt here(sorry for the digression )
<QUOTE><s>

</s> Since high progesterone signal the body potassium deficiency<e>

</e></QUOTE>
I thought high progestrone signals potassium retention while potassium deficiency signals progestrone secretion in order to retain K right ! That means for a normal healthy dude , exogenous progestrone might cause hyperkalemia due to kidneys retaining potassium and excreting sodium ( may be that's why the people at RPF crowd taking exogenous prog crave salt so much ), why will the insulin go down in this case since there is ample serum K ? Besides , the paper you linked is about mutant mice with gestastional diabetes. <br/>
I can link a paper here and say<br/>
<URL url="https://www.ncbi.nlm.nih.gov/pubmed/7039319">https://www.ncbi.nlm.nih.gov/pubmed/7039319</URL><br/>
Quoting from the paper - <br/>
"<I><s></s>This steroid induces <B><s></s>hyperinsulinemia<e></e></B><e></e></I>, possibly by direct action on pancreatic islets, while promoting glycogen storage in the liver. Paradoxically, it antagonizes the effects of insulin on glucose metabolism in adipose tissue and skeletal muscle "
<e>

</e></QUOTE>

<br/>
this is exactly what I wrote, if your progesterone is high , that means potassium deficiency. And progesterone is raised to retain potassium . And also it blocks aldo receptors.<br/>
<br/>
High progesterone will stop insulin secretion. There are gazzilion studies about it, It will cause frank diabetes.<br/>
<br/>
Unfortunately insulin secretion will depend on level of progesterone and not level of potassium. SO if you have high progesterone levels, body thinks you are low on potassium and will stop insulin secretion, since insulin secretion depends on sodium in the cell.<br/>
<br/>
<br/>
This is why no one should be taking hormones unless hormones are low and even then you cant take it. since you will not be able to lower the dosage when minerals is retained. LOL. Most people have high progesterone. And low progesterone will be if potassium is sky high in the cell or you have zero hormones. Most people waste potassium. so when women keep taking progesterone instead of potassium. They are increasing their metabolism with simultaneous decrease of insulin. END EFFECT = HORROR STORIES with panic attacks. Progesterone levels should be falling with potassium retention , but if you are taking it from the outside the fall does not happen. And you end up with low sodium and high potassium in the cell. HUGE CATABOLISM and real problems.</r>

 

[Nighteyes]

Re: PFS and inmune connection

<t>Interesting connection between acidosis and the immune system gbolduev. Am I understanding it correctly that low potassium in the cell and high lactic acid (and slow oxidiser) most likely means being in alkalosis? and thus not able to mount an immune response/not getting sick? Or is high lactic acid more often a symptom of acidosis?</t>

 

[BeLikeWater]

Re: PFS and inmune connection

<r><QUOTE author="gbolduev" post_id="4402" time="1510915322" user_id="90"><s>

</s>
<QUOTE author="BeLikeWater" post_id="4401" time="1510913047" user_id="112"><s>

</s>
Can we relate to the thread theme dont interfere.<br/>
<br/>
For example take exogenous test or increase DHT with things like Sorghum end up with better 5arw activity (better sebum) but feeling worse mentally, brain fog, etc... Seems the key here is upgrade 5ar1 activity to have DHT in brain, allo, etc...
<e>

</e></QUOTE>

<br/>
This is related to this thread and immune response. PFS puts you into alkalosis and this does not allow immune response to happen. Usually when you get sick, you go into acidosis. In PFS you cant do it. And thus you are getting chronic infections, which when you start fixing alkalosis you will FEEL so much it is not even funny. You will be sick big time.<br/>
<br/>
taking exogenous test or DHT causes you to downregulate 3 beta hsd and 450scc. Which is already downregulated. thus your iron is not being used HENCE no immune response.<br/>
<br/>
Same happens with POIS people. when POIS people get sick, their pois disappears. they dont get sick often since they are in alkalosis. In alkalosis there is no immune response. And when you have flu body tries to go into acidosis , which lowers cortisol since acidosis tanks potassium in the cell. When potassium is tanked , cortisol needs to be broken down. and it is broken down by 5 alpha reductase 2. Thus its activity goes UP and most PFS and POIS symptoms disappear. The only problem is this will raise progesterone requirement and wont allow 5 alpha reductase to go online fully. Thus you need to create an environment when both progesterone and cortisol ARE NOT NEEDED. only this will put 5 alpha reductase back online.<br/>
<br/>
Taking cortisol tanks immune system. And increases 5 alpha reducates 2. since it is needed to break down cortisol and progesterone into it metabolites.<br/>
<br/>
<br/>
taking high dose progesterone or dexamethasone at the same time would force the body to upregulate 5 alpha reductase 2.<br/>
<br/>
But it is much easier to do the same with mineral route which I outlined<br/>
<br/>
Copper keep thyroid low, while you increase potassium. This will allow both cortisol and progesterone to come down. And this will allow upregulation of 5 alpha reducate 2<br/>
<br/>
<br/>
<br/>
Bottom line. Finasteride blocks 5 alpha reductase 2. this happens since finasterid is progestine which effects both cortisol and progesterone. this causes the unsolvable alkalotic discrepancy between cortisol and progesterone.<br/>
<br/>
<br/>
Cortisol lowers potassium in the cell, progesterone increases potassium in the cell. HERE you have both high progesterone and high cortisol . And cortisol cant come down, since progesterone is retaining the potassium. And progesterone cant come down, since 5 alpha reductase 2 is down. 5 alpha reductase 2 cant go back up, since cortisol is needed, since potassium is sky high in the cell, because of alkalosis.<br/>
<br/>
You see the mechanism here. <br/>
<br/>
To break this mechanism. you need to create an environment when both cortisol and progesterone are satisfied.<br/>
<br/>
Progesterone is satisfied by potassium. Cortisol is satisfied by lower metabolism( copper) Mangesium gets rid of sodium retention which cortisol caused. B2 lowers serotonin<br/>
<br/>
<br/>
<br/>
INSULIN will go up , only when progesterone COMES DOWN. Since high progesterone signal the body potassium deficiency, and in potassium deficiency insulin secretion will be ZERO. Since insulin puts potassium in the CELL.<br/>
<br/>
<br/>
PROGESTERONE causes INSULIN TO BE ZERO and actually causes FRANK DIABETES.<br/>
<br/>
<URL url="http://www.pnas.org/content/99/24/15644.full">http://www.pnas.org/content/99/24/15644.full</URL> <br/>
<br/>
RU486 reverses this.<br/>
<br/>
<br/>
But progesterone is raised in the body when potassium is deficient. Thus you better off take the mineral route that I outlined
<e>

</e></QUOTE>

Actually we have a PFS group in Spain and we never got ill once while in PFS, we ususally got the flu once a year, now we didnt have it once... And thats typical with PFS.</r>

 

[TubZy]

Re: PFS and inmune connection

<r><QUOTE author="BeLikeWater" post_id="4443" time="1510933940" user_id="112"><s>

</s>
<QUOTE author="gbolduev" post_id="4402" time="1510915322" user_id="90"><s>

</s>
<QUOTE author="BeLikeWater" post_id="4401" time="1510913047" user_id="112"><s>

</s>
Can we relate to the thread theme dont interfere.<br/>
<br/>
For example take exogenous test or increase DHT with things like Sorghum end up with better 5arw activity (better sebum) but feeling worse mentally, brain fog, etc... Seems the key here is upgrade 5ar1 activity to have DHT in brain, allo, etc...
<e>

</e></QUOTE>

<br/>
This is related to this thread and immune response. PFS puts you into alkalosis and this does not allow immune response to happen. Usually when you get sick, you go into acidosis. In PFS you cant do it. And thus you are getting chronic infections, which when you start fixing alkalosis you will FEEL so much it is not even funny. You will be sick big time.<br/>
<br/>
taking exogenous test or DHT causes you to downregulate 3 beta hsd and 450scc. Which is already downregulated. thus your iron is not being used HENCE no immune response.<br/>
<br/>
Same happens with POIS people. when POIS people get sick, their pois disappears. they dont get sick often since they are in alkalosis. In alkalosis there is no immune response. And when you have flu body tries to go into acidosis , which lowers cortisol since acidosis tanks potassium in the cell. When potassium is tanked , cortisol needs to be broken down. and it is broken down by 5 alpha reductase 2. Thus its activity goes UP and most PFS and POIS symptoms disappear. The only problem is this will raise progesterone requirement and wont allow 5 alpha reductase to go online fully. Thus you need to create an environment when both progesterone and cortisol ARE NOT NEEDED. only this will put 5 alpha reductase back online.<br/>
<br/>
Taking cortisol tanks immune system. And increases 5 alpha reducates 2. since it is needed to break down cortisol and progesterone into it metabolites.<br/>
<br/>
<br/>
taking high dose progesterone or dexamethasone at the same time would force the body to upregulate 5 alpha reductase 2.<br/>
<br/>
But it is much easier to do the same with mineral route which I outlined<br/>
<br/>
Copper keep thyroid low, while you increase potassium. This will allow both cortisol and progesterone to come down. And this will allow upregulation of 5 alpha reducate 2<br/>
<br/>
<br/>
<br/>
Bottom line. Finasteride blocks 5 alpha reductase 2. this happens since finasterid is progestine which effects both cortisol and progesterone. this causes the unsolvable alkalotic discrepancy between cortisol and progesterone.<br/>
<br/>
<br/>
Cortisol lowers potassium in the cell, progesterone increases potassium in the cell. HERE you have both high progesterone and high cortisol . And cortisol cant come down, since progesterone is retaining the potassium. And progesterone cant come down, since 5 alpha reductase 2 is down. 5 alpha reductase 2 cant go back up, since cortisol is needed, since potassium is sky high in the cell, because of alkalosis.<br/>
<br/>
You see the mechanism here. <br/>
<br/>
To break this mechanism. you need to create an environment when both cortisol and progesterone are satisfied.<br/>
<br/>
Progesterone is satisfied by potassium. Cortisol is satisfied by lower metabolism( copper) Mangesium gets rid of sodium retention which cortisol caused. B2 lowers serotonin<br/>
<br/>
<br/>
<br/>
INSULIN will go up , only when progesterone COMES DOWN. Since high progesterone signal the body potassium deficiency, and in potassium deficiency insulin secretion will be ZERO. Since insulin puts potassium in the CELL.<br/>
<br/>
<br/>
PROGESTERONE causes INSULIN TO BE ZERO and actually causes FRANK DIABETES.<br/>
<br/>
<URL url="http://www.pnas.org/content/99/24/15644.full">http://www.pnas.org/content/99/24/15644.full</URL> <br/>
<br/>
RU486 reverses this.<br/>
<br/>
<br/>
But progesterone is raised in the body when potassium is deficient. Thus you better off take the mineral route that I outlined
<e>

</e></QUOTE>

Actually we have a PFS group in Spain and we never got ill once while in PFS, we ususally got the flu once a year, now we didnt have it once... And thats typical with PFS.
<e>

</e></QUOTE>

I had the opposite. Picked up mono, constant sinus infections since PFS, allergies 20 times worse etc. Actually, got mono literally coming off of fin.</r>

 

[Helen]

Re: PFS and inmune connection

<r><QUOTE author="BeLikeWater" post_id="4443" time="1510933940" user_id="112"><s>

</s>
<QUOTE author="gbolduev" post_id="4402" time="1510915322" user_id="90"><s>

</s>
<QUOTE author="BeLikeWater" post_id="4401" time="1510913047" user_id="112"><s>

</s>
Can we relate to the thread theme dont interfere.<br/>
<br/>
For example take exogenous test or increase DHT with things like Sorghum end up with better 5arw activity (better sebum) but feeling worse mentally, brain fog, etc... Seems the key here is upgrade 5ar1 activity to have DHT in brain, allo, etc...
<e>

</e></QUOTE>

<br/>
This is related to this thread and immune response. PFS puts you into alkalosis and this does not allow immune response to happen. Usually when you get sick, you go into acidosis. In PFS you cant do it. And thus you are getting chronic infections, which when you start fixing alkalosis you will FEEL so much it is not even funny. You will be sick big time.<br/>
<br/>
taking exogenous test or DHT causes you to downregulate 3 beta hsd and 450scc. Which is already downregulated. thus your iron is not being used HENCE no immune response.<br/>
<br/>
Same happens with POIS people. when POIS people get sick, their pois disappears. they dont get sick often since they are in alkalosis. In alkalosis there is no immune response. And when you have flu body tries to go into acidosis , which lowers cortisol since acidosis tanks potassium in the cell. When potassium is tanked , cortisol needs to be broken down. and it is broken down by 5 alpha reductase 2. Thus its activity goes UP and most PFS and POIS symptoms disappear. The only problem is this will raise progesterone requirement and wont allow 5 alpha reductase to go online fully. Thus you need to create an environment when both progesterone and cortisol ARE NOT NEEDED. only this will put 5 alpha reductase back online.<br/>
<br/>
Taking cortisol tanks immune system. And increases 5 alpha reducates 2. since it is needed to break down cortisol and progesterone into it metabolites.<br/>
<br/>
<br/>
taking high dose progesterone or dexamethasone at the same time would force the body to upregulate 5 alpha reductase 2.<br/>
<br/>
But it is much easier to do the same with mineral route which I outlined<br/>
<br/>
Copper keep thyroid low, while you increase potassium. This will allow both cortisol and progesterone to come down. And this will allow upregulation of 5 alpha reducate 2<br/>
<br/>
<br/>
<br/>
Bottom line. Finasteride blocks 5 alpha reductase 2. this happens since finasterid is progestine which effects both cortisol and progesterone. this causes the unsolvable alkalotic discrepancy between cortisol and progesterone.<br/>
<br/>
<br/>
Cortisol lowers potassium in the cell, progesterone increases potassium in the cell. HERE you have both high progesterone and high cortisol . And cortisol cant come down, since progesterone is retaining the potassium. And progesterone cant come down, since 5 alpha reductase 2 is down. 5 alpha reductase 2 cant go back up, since cortisol is needed, since potassium is sky high in the cell, because of alkalosis.<br/>
<br/>
You see the mechanism here. <br/>
<br/>
To break this mechanism. you need to create an environment when both cortisol and progesterone are satisfied.<br/>
<br/>
Progesterone is satisfied by potassium. Cortisol is satisfied by lower metabolism( copper) Mangesium gets rid of sodium retention which cortisol caused. B2 lowers serotonin<br/>
<br/>
<br/>
<br/>
INSULIN will go up , only when progesterone COMES DOWN. Since high progesterone signal the body potassium deficiency, and in potassium deficiency insulin secretion will be ZERO. Since insulin puts potassium in the CELL.<br/>
<br/>
<br/>
PROGESTERONE causes INSULIN TO BE ZERO and actually causes FRANK DIABETES.<br/>
<br/>
<URL url="http://www.pnas.org/content/99/24/15644.full">http://www.pnas.org/content/99/24/15644.full</URL> <br/>
<br/>
RU486 reverses this.<br/>
<br/>
<br/>
But progesterone is raised in the body when potassium is deficient. Thus you better off take the mineral route that I outlined
<e>

</e></QUOTE>

Actually we have a PFS group in Spain and we never got ill once while in PFS, we ususally got the flu once a year, now we didnt have it once... And thats typical with PFS.
<e>

</e></QUOTE>

I got mono coming off PFS the first time. And then body went into alkalosis. and you dont get flu in alkalosis. <br/>
<br/>
Thus if you ever get sick you can just take baking soda. and your sick effects will go down immediately. NEVER do this , acidosis is needed to cure the infection</r>

 

[wuf]

Re: PFS and inmune connection

<t>"Actually we have a PFS group in Spain and we never got ill once while in PFS, we ususally got the flu once a year, now we didnt have it once... And thats typical with PFS."<br/>
<br/>
Same for me. Never had any flu symptoms. Very very rare in my PFS years state.</t>