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We still dont understand PFS PSSD exactly, but we do understand what possibilities we have . I will try to outline the possibilities what went wrong and different scenarios
1) as we know Italian study found AR receptors to be very overexpressed . So in this case we can assume that overexperssion of the receptors is the main problem. and this is why the body shuts down the whole axis, since it is too sensitive to DHT lets say.
2) we know that receptors are overexpressed but we assume that overexperssion of the receptors is the regulatory reaction, since there is not enough 5 alpha reductase and no enough DHT present.
3) although italian study showed the overexpression of the receptors we need to also assume that there could be also downregulated receptors in some cases. and DHT is not sensitive .
4) same cases we can assume with the cortisol receptor. Since some people feel totaly recovered when on dexamethasone.
This is to be continued.
1) as we know Italian study found AR receptors to be very overexpressed . So in this case we can assume that overexperssion of the receptors is the main problem. and this is why the body shuts down the whole axis, since it is too sensitive to DHT lets say.
2) we know that receptors are overexpressed but we assume that overexperssion of the receptors is the regulatory reaction, since there is not enough 5 alpha reductase and no enough DHT present.
3) although italian study showed the overexpression of the receptors we need to also assume that there could be also downregulated receptors in some cases. and DHT is not sensitive .
4) same cases we can assume with the cortisol receptor. Since some people feel totaly recovered when on dexamethasone.
This is to be continued.