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Here is a possible theory of what is going on.
Fins binds NADPH. ( it is a fact) which basically impairs at least 5-6 hormones. ( may be more) From the studies we know that it is 17 estradiol, which is converted from estrone with NADPH, it is DHT which is converted via 5 alpha reductase, then it is pregnenolone. and progesterone. I think there is actually more hormones, involved. cortisol for instance.
When hormones are severely diminished. brain upregulates their receptors expression in the brain big time.( may be upregulates methylation) And since brain senses and regulates these hormones. Then the signaling is increased big time into the brain when hormones are inhibited, since it is vital for survival of the brain.
After you quit finasteride hormones go up first, and then they go into the spinal cord. But since brain upregulated sensitivity to these hormones. Brain sends a signal to bind them in blood. to proteins. And binds them like you read about and inactivates them.. this is why tissues dont get any of these hormones and body is aging . this might explain overexpression in the skin studies.
And also explains disconnection of brain and dick. Also explains ( high libido, not low mental libido is high) people want sex. If libido were low, they would not be checking how their dick hangs or works. Libido and desire is high, the ability to perform is zero.
This is why we see high hormones in blood, and low in CSF. brain does not want them.
to get into CSF the hormones have to be in FREE form in plasma. Meaning free DHT, Free progesterone, Free thryoid, etc. Normal hormones cant get into CSF
This is how brain regulates uptake into CSF ( spinal fluid by freeing hormones.)
this is why fasting helps, since you run low on protein. and the binding mechanism loosens up. but then when you start eating again, it goes back up.
So basically just feed hormones which were inhibited by fin,( which are low in CSF) overwhelm binding mechanisms, and brain will downregulate. Plus you will feed all these needed hormones into tissues at the same time.
As brain downregulates, when you quit hormones, on the snap back. brain wont bind them anymore. Since it would want more of them.
Another possibility would be to increase NADPH production a lot with NADPH precursors.. 2 gm a day of B1. or may be niacin. you will feel bad, just stick with it. and after you get off. you will see all your hormones work again.
Do like 2-3 weeks on , and then off.
Also demethylation enzymes might be looked at as we talked about. where b2 could play a big role. I seem some people just taking B2 and improving over time.
Some discussion of this and CSF values also taking place in this thread. https://hackstasis.com/threads/neur...ways-to-fix-pfs-or-understand-it-better.1416/
Fins binds NADPH. ( it is a fact) which basically impairs at least 5-6 hormones. ( may be more) From the studies we know that it is 17 estradiol, which is converted from estrone with NADPH, it is DHT which is converted via 5 alpha reductase, then it is pregnenolone. and progesterone. I think there is actually more hormones, involved. cortisol for instance.
When hormones are severely diminished. brain upregulates their receptors expression in the brain big time.( may be upregulates methylation) And since brain senses and regulates these hormones. Then the signaling is increased big time into the brain when hormones are inhibited, since it is vital for survival of the brain.
After you quit finasteride hormones go up first, and then they go into the spinal cord. But since brain upregulated sensitivity to these hormones. Brain sends a signal to bind them in blood. to proteins. And binds them like you read about and inactivates them.. this is why tissues dont get any of these hormones and body is aging . this might explain overexpression in the skin studies.
And also explains disconnection of brain and dick. Also explains ( high libido, not low mental libido is high) people want sex. If libido were low, they would not be checking how their dick hangs or works. Libido and desire is high, the ability to perform is zero.
This is why we see high hormones in blood, and low in CSF. brain does not want them.
to get into CSF the hormones have to be in FREE form in plasma. Meaning free DHT, Free progesterone, Free thryoid, etc. Normal hormones cant get into CSF
This is how brain regulates uptake into CSF ( spinal fluid by freeing hormones.)
this is why fasting helps, since you run low on protein. and the binding mechanism loosens up. but then when you start eating again, it goes back up.
So basically just feed hormones which were inhibited by fin,( which are low in CSF) overwhelm binding mechanisms, and brain will downregulate. Plus you will feed all these needed hormones into tissues at the same time.
As brain downregulates, when you quit hormones, on the snap back. brain wont bind them anymore. Since it would want more of them.
Another possibility would be to increase NADPH production a lot with NADPH precursors.. 2 gm a day of B1. or may be niacin. you will feel bad, just stick with it. and after you get off. you will see all your hormones work again.
Do like 2-3 weeks on , and then off.
Also demethylation enzymes might be looked at as we talked about. where b2 could play a big role. I seem some people just taking B2 and improving over time.
Some discussion of this and CSF values also taking place in this thread. https://hackstasis.com/threads/neur...ways-to-fix-pfs-or-understand-it-better.1416/
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