Phosphatidylserine & Phosphatidylcholine

[TubZy]

So we all know that [mention]gbolduev[/mention] likes sunflower lecithin (high in PC, PS etc.) for hair purposes so I decided to research it further and found some cool stuff.

PS/PC resetting cortisol sensitivity (pituitary)

A soy-based phosphatidylserine/ phosphatidic acid complex (PAS) normalizes the stress reactivity of hypothalamus-pituitary-adrenal-axis in chronica... - PubMed - NCBI
The effects of phosphatidylserine on endocrine response to moderate intensity exercise
Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress. - PubMed - NCBI
Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men. - PubMed - NCBI

PS/PC and 5AR

Specific stimulation of steroid 5 alpha-reductase solubilized from rat liver microsomes by endogenous phosphatidylserine. - PubMed - NCBI
Partial characterization of testosterone 5 alpha-reductase solubilized from rat testicular microsomes. - PubMed - NCBI
Modulation of epididymal delta 4-steroid 5 alpha-reductase activity in vitro by the phospholipid environment.
Phospholipase A2 degradation products modulate epithelial and stromal 5α‐reductase activity of human benign prostatic hyperplasia in vitro
Phospholipid requirement of progesterone 5 alpha-reductase from gastric mucosa microsomes of guinea pig. - PubMed - NCBI
Some properties of progesterone 5 alpha-reductase solubilized from rat liver microsomes. - PubMed - NCBI
Phosphatidylcholine - an overview | ScienceDirect Topics

Even egg lecithin too

http://www.jbc.org/content/260/12/7489.full.pdf

The inclusion of egg lecithin, a mixture of phosphatidylcholines, in assays of solubilized 5a-reductase enhanced activity. The 2.2-fold increase in nuclear 5a-reductase activity was sufficient to completely restore the membrane-bound specific activity, but the enhancement of the microsomal 5a-reductase (1.3-fold) was not sufficient in this respect.

 

[Aleksandr]

Thanks for the info Tubzy.

One thing i've noticed with the sunflower lecithin is that it makes my scalp / forehead / temples sunburn more easily. I've noticed this in the past too... the more PUFA i have, the more i get sunburnt. Zero pufa, zero sunburn... just tanning.

It seems like the opposite with cold tolerance, fatter people seem to be able to tolerate the cold really well. I'm pretty lean at the moment (13% bodyfat around) and I freeze quickly in cold water. Dunno if this is to do with PUFA of general fatness. One thing is for sure, 99% of overweight people you see are most definitely PUFA-laden.

 

[TubZy]

Thanks for the info Tubzy.

One thing i've noticed with the sunflower lecithin is that it makes my scalp / forehead / temples sunburn more easily. I've noticed this in the past too... the more PUFA i have, the more i get sunburnt. Zero pufa, zero sunburn... just tanning.

It seems like the opposite with cold tolerance, fatter people seem to be able to tolerate the cold really well. I'm pretty lean at the moment (13% bodyfat around) and I freeze quickly in cold water. Dunno if this is to do with PUFA of general fatness. One thing is for sure, 99% of overweight people you see are most definitely PUFA-laden.

Yeah man the liquid is rough. I was more interested in taking it orally in the form of powder or granules. Could be interesting, it seems like it is good for the liver as well which PFS (increases 5AR, can resensitize cortisol) seems to cause fatty liver. Supposley it can be good for the hair and skin internally but not sure how accurate that is.

 

[Continuous Heal]

PS supplementation was the largest and only clear cut victory for me in my battle with PFS.

Approximately 4-5 years ago, I had bloods done, saw high cortisol, and in a really uneducated way, sought out supplements known to lower it. Luckily I bought a bottle of PS and hoped to see my daytime stress level fall.

Rather than having that expectation materialize, within a week of beginning, I began to start to have real sleeps again, for the first time since my PFS issue began. I noticed movement in my scrotum again, which had at that point not been happening for years.

I continued to supplement daily for ~2 years after this happened, and it began my quest of knowledge into this subject that has ultimately led me here. I would recommend that anyone still suffering with PFS give it a try immediately.

I would also love to hear more about how the mechanism discussed above connects to gbolduev's theory of PFS. I do not supplement PS these days, as it seemed benefit had topped out. I am certainly not fully recovered however.

 

[Minime]

PS supplementation was the largest and only clear cut victory for me in my battle with PFS.

Approximately 4-5 years ago, I had bloods done, saw high cortisol, and in a really uneducated way, sought out supplements known to lower it. Luckily I bought a bottle of PS and hoped to see my daytime stress level fall.

Rather than having that expectation materialize, within a week of beginning, I began to start to have real sleeps again, for the first time since my PFS issue began. I noticed movement in my scrotum again, which had at that point not been happening for years.

I continued to supplement daily for ~2 years after this happened, and it began my quest of knowledge into this subject that has ultimately led me here. I would recommend that anyone still suffering with PFS give it a try immediately.

I would also love to hear more about how the mechanism discussed above connects to gbolduev's theory of PFS. I do not supplement PS these days, as it seemed benefit had topped out. I am certainly not fully recovered however.

Just curious...did the benefits from CS stick, or did you regress after you stopped supplementing with it?

 

[Continuous Heal]

Just curious...did the benefits from CS stick, or did you regress after you stopped supplementing with it?

I feel like some of the benefits may have blunted through time, however I never went back to the horrible condition I was in prior to it. My sleep has remained well above where I was then, as well as the feel in the scrotum / improvement in sexual activity.

I was truly in horrible condition before it, and that has definitely not come back.

 

[Minime]

I feel like some of the benefits may have blunted through time, however I never went back to the horrible condition I was in prior to it. My sleep has remained well above where I was then, as well as the feel in the scrotum / improvement in sexual activity.

I was truly in horrible condition before it, and that has definitely not come back.

I took PC a few different times at the advice of my doctor. The first time, I experienced some good benefits initially. They subsided however. The other two times I took PC I did not feel any benefit whatsoever. That is one of the most frustrating things for me in my battle with PFS. If I get any positive benefits from something, they are always temporary and I do not seem to re-experience those benefits even if I stop taking the supplement for a few months and jump back on it. Very strange. I’m happy for you though...glad your positive benefits have stuck!

 

[Continuous Heal]

I took PC a few different times at the advice of my doctor. The first time, I experienced some good benefits initially. They subsided however. The other two times I took PC I did not feel any benefit whatsoever. That is one of the most frustrating things for me in my battle with PFS. If I get any positive benefits from something, they are always temporary and I do not seem to re-experience those benefits even if I stop taking the supplement for a few months and jump back on it. Very strange. I’m happy for you though...glad your positive benefits have stuck!

Try PS. After my good experience with it, I tried PC, and didn't see significant improvement.

 

[joekool]

I've wanted to try and did once but the oil capsuled gave me diarrhea. I don't mind I guess if what everyone is saying outweighs that but I'd love a powdered or pill form

 

[joekool]

I found some dry examples on Amazon. I'll order in a week.

 

[joekool]

Phosphatidylserine 500mg Memory Ultimate plus Ginkgo and DMAE 100 capsules Best Value Phosphatidyl Serine https://www.amazon.com/dp/B01I1YS9DG/ref=cm_sw_r_cp_apa_bN9uAb6338RB3

Ordered this one. Has some extras for nerves including dmae. I'm going to dose 2 pills twice a day.

 

[Continuous Heal]

Phosphatidylserine 500mg Memory Ultimate plus Ginkgo and DMAE 100 capsules Best Value Phosphatidyl Serine https://www.amazon.com/dp/B01I1YS9DG/ref=cm_sw_r_cp_apa_bN9uAb6338RB3

Ordered this one. Has some extras for nerves including dmae. I'm going to dose 2 pills twice a day.

I used natural factors, which itself seemed to license a version called "Sharp-PS Green", which I saw from other companies as well. It was oil capsule though.

 

[joekool]

Cool , I'm hoping this one is equal in PS content & strength as the one you're using... though I'll need two pills to equal the potent of 1 from your choice ... but I'm going to double dosage taking 2 pills AM and 2 more PM. Thanks man... stick around on this forum...

 

[Bankai900]

Thanks for the info Tubzy.

One thing i've noticed with the sunflower lecithin is that it makes my scalp / forehead / temples sunburn more easily. I've noticed this in the past too... the more PUFA i have, the more i get sunburnt. Zero pufa, zero sunburn... just tanning.

It seems like the opposite with cold tolerance, fatter people seem to be able to tolerate the cold really well. I'm pretty lean at the moment (13% bodyfat around) and I freeze quickly in cold water. Dunno if this is to do with PUFA of general fatness. One thing is for sure, 99% of overweight people you see are most definitely PUFA-laden.

@Aleksandr

Sorx for digging up old stuff
After crash I was as pale as a corpse, looked horrific when I saw myself around others in the gym and remember I couldn't get a tan even when I was out in the sun quite awhile.

But now I'm tanning ultrafast, I get barely any sunburn and I'm not out much in the sun, yet I'm tanned as if I'd lay 6h a day in the sun.
(dk if this is worth a mention, my skin started sweating a bit more (good I think), even precrash I was barely sweating at all.)

So is getting tanned as awful in that sense? Or is getting sunburned (red/pink) the enemy? I remember precrash I'd usually be red for quite awhile before getting bronze but with quite some sunexposure, but now I'm like instantly dark without even being much out and with daily spf15 on face. So am I fakd or is this good haha

 

[Aleksandr]

@Aleksandr

Sorx for digging up old stuff
After crash I was as pale as a corpse, looked horrific when I saw myself around others in the gym and remember I couldn't get a tan even when I was out in the sun quite awhile.

But now I'm tanning ultrafast, I get barely any sunburn and I'm not out much in the sun, yet I'm tanned as if I'd lay 6h a day in the sun.
(dk if this is worth a mention, my skin started sweating a bit more (good I think), even precrash I was barely sweating at all.)

So is getting tanned as awful in that sense? Or is getting sunburned (red/pink) the enemy? I remember precrash I'd usually be red for quite awhile before getting bronze but with quite some sunexposure, but now I'm like instantly dark without even being much out and with daily spf15 on face. So am I fakd or is this good haha

Dunno lol sounds like a good thing?