Possible PFS Approach

[bruschi11]

I think the step between folate to bh4 might be the biggest thing.

This requires NADPH and folic acid.

I think a big misconception is how people choose b1 as the big one for nadph. But what if someone is short on acetyl CoA? B1 can deplete even more.

I think it’s more about allowing the body to use b1. Body can’t use it in many cases. For me… it’s been about fixing the system quite a bit before b1 can be taken. Which starts with acetyl coa. Which needs Coa (active b5 via carnitine and b5), NAD, and Pyruvate.

I think getting to nadph between b5 and carnitine might be the start along with a little biotin maybe manganese/zinc (these low dose) . This should get nadph working. Then get folate involved. As nadph uses folate to get to bh4.

I’ve been trying to fix urea cycle recently. Bunch of biotin amongst other urea cycle cofactors. Could tolerate like 10mg no problem. Now I started getting b5 carnitine in along with folate. Biotin just 1mg made me go insane! Extreme nitric oxide production and way too much carbon monoxide really burning my brain in worst of ways.

I went overboard clearly not knowing I was starting something up. The b5 carnitine folate (getting to bh4) caused biotin to become infinitely stronger. While neurologically it was too much on me. Libido exploded.

Some may need tiny amounts of b2. Some may need b12, b3. Electrolytes psycho important.

Again this is what sucks in all this. Having a lab on hand is best. And luckily I basically have that.

I watched folate go down on my screen as I got nadph working. Putting folate in changed something. Then biotin was psycho strong.

Remember… in pfs arginine goes down . And histidine. What I write above is route to arginine.

Histidine should work with NAD atp manganese carnitine in my experiences. Manganese can push histidine too hard.

We need iron for No production and histidine provides that iron that the nitric oxide system needs.

 

[bruschi11]

The problem here for me is carbon monoxide. I died yesterday and carbon monoxide went up crazy high. I wonder how many pfs guys have this problem. I honestly don’t think the number is high to be honest.

But if you have low Co2. Like I have chronically. You may need to keep Co2 up for awhile before getting to NO. Which is probably why you gotta keep biotin in low low dose. You can’t get zinc toxic either. I believe I’m a bit zinc toxic currently as well.

If you turn on NO in a system that cannot tolerate the carbon monoxide. You die. Ray Peat was against NO for a reason and that’s carbon monoxide. Hydroxy and possibly methyl b12 can help here. Manganese .

Another thing is getting to carnitine needs methionine and lysine. So again b12 biotin. Some may need to feed lysine if biotin isn’t getting there. I believe lysine is something I will be trying shortly taking demand off biotin there.

This also all dies without active b6. Which needs FMN (via b2 selenium) and magnesium. FMN can be given directly via R5p supplement. I’ve been giving legit 3mg of R5p every couple days.

Have to realize once you get nadph working, this takes demand off b2. As nadph is for glutathione reductase (recycling.) Leaving less pressure on glutathione peroxidase (gluth production/b2.)

Some may need molybdenum to get FmN to FAD. But we don’t want too much FAD. We want to work off nadph. FAD depletes b5 the route to NADPH.

 

[bruschi11]

Starting to think malic acid with all this. Taking pressure off carnitine (Fumarate) in Krebs.

Carnitine Keeps dropping in biofeedback. Body needs it so bad.

Now I think back to 2017 recovery. It really was October 2017 I became alive. Like I was dead headed prior. What started in late September? BOTH malic acid for liver flushes AND injectable carnitine.

These take pressure off biotin getting to Oxaloacetate retaining Pyruvate as well. Malic gets to Pyruvate.

Moritz helped a lot of people. With a vegan diet…. But tons of malic. Have to wonder… the guy was doing something right. And malic is located in a prime spot in the Krebs cycle.

I’m literally drinking some for first time since June 2022 where I did one flush and prior was legit early 2020. Not planning on flushing too sick for that right now. But malic when looking at the Krebs cycle really seems to make sense.

 

[bruschi11]

For normal people malic should be great as you’re both turning on nadph and retaining biotin.

But it can be pushed too hard. And it’s definitely not something I can push too hard right now. Nadph goes too hard depleting glycolysis, coenzyme A components. Along with folic cycle components.

But this was good to know. Lysine—-> carnitine + b5 /b3 probably best for right now when it comes to pushing nadph.

 

[bruschi11]

From testing myself it’s easy to see….

B12 is moving biotin to lysine. But lysine piles up and doesn’t get to carnitnine? Why?

B3/NAD dies. So biotin to lysine is via b12 (or maybe just methionine) lysine to carnitine via NAD.

Which is pretty crazy. My big improvements last fall were between b3 at first and then adding b12. B3 was needed for a short time after b12 then it was b12 and b2 then just b2 as b12 would hurt then b2 would hurt and I was dying for copper. I was dying for copper cuz I needed biotin (never touched it.)

Instead I just gave copper zinc and finally Dhea helped a lot with the cu deficiency. But crashed me 6 weeks into it.

My amino acids last fall agree with what I’m saying. I fixed arginine methionine lysine (the big 3 I call them) also histidine ornithine. But citrulline was down. Ya zinc helped (gets to citrulline) but zinc needed biotin for help.

When I was dealing with bad b3 deficiency in l fall 2022…. I would get horrid horrid armpit infection. Smelled sooo bad…. And here it is. It’s back! It smells horrrrible. It hurts. Lol this life.

I am going to try carnitine Fumarate and/or tartrate in place of acetyl. I’m being told acetyl groups can mitigate NAD. And I’ve been using a lot of acetyl carnitine 3-4 caps a day.

Today is my birthday. I just turned 35 overnight. I can’t believe how bad the last half decade has been. After the best year of my life being 29 when I recovered from Lyme/ pfs. I just hope it’s not too late now cuz I really feel I have a good view on this all.

Krebs and methylation go hand in hand. Krebs feeds methylation. That’s how I’m seeing it.

 

[bruschi11]

I was accurate about the first thing I said way above. It’s about nadph and folic acid getting us to bh4.

You can’t give much b2 or methylfolate until histidine drops if histidine is high. To lower histidine you b12 folic acid nadph NRF2. NRF2 can push nadph and require b1.

With hisitidine high, Cysteine is going to sulfite hard. Molybdenum required there.

I really messed up. I didn’t folllow this at all. I was focusing on non pfs stuff but the non pfs stuff was the same problem that needed to be fixed .

I honestly think BMAA toxicity and pfs need the same approach. Like so many neuro diseases. Get yourself in and recycling bh4. Vitamin C recycles bh4 too so that and E. NRF2 stuff like coq10 possibly ALA if tolerable.

With all this going on zinc, b6, Biotin are needed. Maybe copper or just vitamin A to move it from liver.

I’m in really big trouble. I feel I dumped iron severely after a phos choline IV and caused Mito damage a month ago. The iv wasn’t that bad. But I kept pushing b2 and phos serine (makes more choline) after the IV. Histidine inflated. I dumped iron so hard.

I’m realizing what had to be done. I might be too late. My head is dissolving but I turn system on and it’s clear I’m making the right chemicals. I got in a little rhythm today but made one mistake taking choline and that hit me really hard.

I think I need to take choline… but Tiny doses. Folic acid uses choline. But not too hard. It lowers it a little. But choline? It absolutely depletes folic acid sooo hard.

Last thing I write for a bit. Unless I know I’m coming back for this or dying . The very best I’ve felt in the last 3.5 years since I got rid of Lyme and this whole mitochondrial illness began… the very best was after taking royal jelly supp (b5), biotin and b1 in fall of 2020. Was taking E at the time a lot of chromium (NRF2). Folinic acid.

I was absolutely getting to bh4. There’s no doubt in my mind that’s what this is all about.

 

[bruschi11]

SaME is needed too. Hence why choline so big. Choline —> tmg—> SaME. B12 probably helps there. But I just feel like choline/tmg just keep that pathway up.

Today the worst supplement to hit me absolutely was choline and it has been repeatedly. Now that doesn’t mean I’m stopping taking it. I will cut the dose down to 1/4th of what I normally take. I still feel it is very much required here.

Choline took down folic acid. Flat out. Killed it. It must be SaME/ folate balance. SaME folinic nadph balance in some way or form.

Mario Vitali story who is now CFS researcher. Cured himself after 15 years with pfs/CFS. His approach was b1, b6, folate zinc I think some Biotin and he eventually dropped it. And I talked to him after and he said he liked mag.

The above is just such a simple way to keep methylation up and get yourself to bh4. But some people need some choline. Some need some b12. Some need both. Some need moly . Some need to control a pathogen load which frees up nutrients by clearing it. Some need all sorts of help and rest and just relax as much as possible for a long time to safe one’s life.

I really hope I’m fixable. I know I was. And I came so close with all of the above in mind. Understanding this now. You have to get to bh4 in methylation and doing that is very difficult when you’re very sick.

I hope to report back here soon with at least decent news. This is scary but I’m going to give this one last shot.