RANDOM QUESTIONS

[D4n]

Does anyone know what would happen if you antagonise and agonise a receptor at the same time ?

 

[Niles]

Here's a random question:

Does anyone know how much elemental copper is in ghk-cu in terms of percent of total weight?

 

[MNK99]

Does anyone know what would happen if you antagonise and agonise a receptor at the same time ?

I am not sure of an exact answer - @D4n, but I'm sure a lot of people do this by accident without even considering it. When they take something to counteract side effects, or to restore sensitivity, or prevent Excitotoxicity. It could be more beneficial in certain cases. I'm not talking about PFS, but more about "drugs"/dopamine, serotonin, norepinephrine. PFS etc affects so so many different things in seemingly very confusing ways.

Maybe also, neurotoxicity or excitotoxicity occurs depending which side "wins".

People who use drugs, do this all the time and then reuptake with smoking, preventing clearing of the synapses. After say X, MDMA, COKE, AMPS, etc.
People who use uppers and downers (that's a bad idea), or alcohol, or any number of things for "come downs".

(-BY the way lots of words, I use are shown as spelling errors when in fact they are spelled correctly. BUT* that would happen on near all word editors too -No big deal) .
Like Excitotoxicity above.

-Went to banff. It was ok most part.

Here's an OLD study, from 1992:

Concurrent agonist-antagonist administration for the analysis and treatment of drug dependence.
Rose JE1, Levin ED.
Author information

Abstract

"Two key strategies for the treatment of drug dependence involve the use of agonists to substitute for the abused drug and the use of antagonists to block the reinforcing actions maintaining drug self-administration. A different strategy for the treatment of drug dependence is outlined, comprising the concurrent administration of an agonist and an antagonist. Concurrent administration of an agonist with an antagonist, in the proper ratio, should produce maximal occupancy of receptors and attenuation of the reinforcing actions of the abused drug. The addict would be relatively "insulated" from the reinforcing effects of the abused drug; at the same time the balance of agonist and antagonist effects is predicted to prevent withdrawal symptoms or intoxication resulting from an under- or over-stimulation of drug receptors. Advantages over the use of agonists alone and antagonists alone, and over mixed agonist-antagonist molecules, are discussed. Application of concurrent agonist-antagonist administration to the analysis of mechanisms underlying nondrug reinforcement and to the treatment of disorders involving receptor disregulation is also described."

 

[MNK99]

1. VANiTy can KILL.
2. PEOPLE AGE.
3. CHANGING YOUR EYEBROW SHAPE IS GOING TOO FAR, RITE?
4. BREAKING TOES TO RESET THEM INTO BETTER SHAPE IS ALSO GOING TOO FAR, RITE? ---NO SANE DOC would approve that.
-ASKING FOR A FRIEND.

 

[bruschi11]

1. VANiTy can KILL.
2. PEOPLE AGE.
3. CHANGING YOUR EYEBROW SHAPE IS GOING TOO FAR, RITE?
4. BREAKING TOES TO RESET THEM INTO BETTER SHAPE IS ALSO GOING TOO FAR, RITE? ---NO SANE DOC would approve that.
-ASKING FOR A FRIEND.

My barber shaped my right eye brow about 2 months ago. This respective eye brow made me insecure around 7th-8th grade through mid high school. Hadn’t thought about it since.

One day after hair cut having known barber was working on eye brows I checked it out and was like “wow, guy did a good job! Now I’m a 7.4/10 before a 6.9”. Right Eye brow now looks great!

Sucks I had to lose the 6.9 out of 10 looks rating. Love saying 69. But 1/2 a point on the looks scale can be huge So I can’t complain.

 

[Niles]

Random question:

If I'm doing just a 24hr fast, should I be careful about what I eat to break it? Or just eat the usual? Any recommendations?

Now that my energy is up, I'm trying to do one 24hr fast/week.

 

[MNK99]

- @Niles
-Bro different for us, but friends do this all the time. Tubzy was less strict with shorter fast than what I was recommended for long fast. For my 48h fasts, mostly vegan and some protein if getting hungry or worked out, but this is like 9months later almost, for me.
-The egg soup or vegan a few days if it's first 24 hrs fast for some time.
-Or vegiie juice for a bit. ****Or veggie broth even safer. Broil veggies 24-48 hrs only have the soup***** --> slowly (7d to 14d getting back to ideal diet). -Or 3-6days.
If you want to be really really careful. ideally have a juicer and or a "slow-cooker"/"crockpot" on hand (you know what I'm saying, those large pots).

 

[RebelWithACause]

Random question:

If I'm doing just a 24hr fast, should I be careful about what I eat to break it? Or just eat the usual? Any recommendations?

Now that my energy is up, I'm trying to do one 24hr fast/week.

24 hour is intermittent fasting. IMO you can eat whatever you want after only 24hr fast. I have done that a lot in past.

 

[MNK99]

--1. Will TEI INCREASE RADIANCE?
--2. WIll TEI fix Gluthianoione (sp?), and Bile production?
--3. Do you guys and girls (1 or 2 or maybe 8. I can think of 6-7 names) believe in FATE/DESTINY?
--4. Are you fatalistic? Do you try not to be?
--5. Fate or Destiny doesn't always have to be bad... nor what you think it is, right?
--6. What if there's no such thing as "good" or "bad"?
--7. What if there's multiple fates? (you make your own luck in life, I usually said... up to a point). But some things you cannot change. You must accept the good and the bad.

 

[HerrFisch]

Anybody else getting stomach pain from folinic acid? (not sure, trying to find the culprit)

 

[Orion]

Any time frame on sending hair sample --> Catherine/TEI and then awaiting results?

Took exactly 2 weeks with Catherine, both times were ARL.

 

[RebelWithACause]

What pathway/minerals are lowered by exogonous DHT or DHT-derivatives like drostanolone?

 

[MNK99]

-1. Did TEI turn anyone into a homosexual? 1.b. Or make them pansexual?
-2. Did it increase their proclivity towards homoeroticisim or omnisexuality??
-3. IS OXI RATE ASSOCIATED WITH GENDER ROLES??
-4. Is Oxi rate directly or inversely related to daintiness?
-5. Is my jaw pain and knee pain and other pain (stretching... like things pop out, like charlie-horse pain), even abs sometimes electrolyte caused (imbalance)?
-6. Is it Ok to induce vomiting to stay thin forever?? Asking for a friend. What do you need? Ipakak? Ipececk? IpiCack?

Ipicat?

 

[RebelWithACause]

When I eat liver I feel like shit afterwards. How come? I get irritated feeling.

 

[vicecaz]

When I eat liver I feel like shit afterwards. How come? I get irritated feeling.

Most likely from its high copper content, do you have the same reaction after eating a lot of pure dark chocolate for instance ? I too felt like shit on high copper foods
Moreover liver is high in purines and I was advised against eating it by TEI on my hair test

 

[MNK99]

-1. No priors (after minor).
-2. Drive no license - no one cares right?
-3. No jail, no one cares rite? @HS @Niles @Chapman?
-3.b., I'm supposed to wait for new license in mail?? -asking for a friend.

 

[SwaZ]

@Helen
Is benfotiamine okay to use as a source of thiamine?

 

[Helen]

@Helen
Is benfotiamine okay to use as a source of thiamine?

yes

 

[RebelWithACause]

- How does progesterone keep potassium high if your intake for example is low?
- Is the reason why finasteride works because it keeps potassium high in the cell? Or is it because it blocks 5AR primarily? Or is it the increase of estrogen by finasteride?

 

[RebelWithACause]

Why is it bad for fast oxidisers to fast?