raven
Well-Known Member
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Some notable results from a 23andMe test I took and ran through Promethease
Finally got my results, here are some of them:
rs6311(C;C)
(All PSSD people seem to have this one)
3.6x increased risk of sexual dysfunction when taking SSRI Antidepressants. Selective Seratonin Reuptake Inhibitors (citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac), paroxetine (Paxil), or sertraline (Zoloft)) cause worse sexual dysfunction (a common side-effect) in people with this SNP. Note that research has shown Saffron is effective at reversing the sexual dysfunction from SSRI anti-depressants.
rs7158782(G;G)
4x higher risk of adverse side-effect if taking aromatase inhibitor
rs7158782 is one of 4 SNPs found on chromosome 14 near a gene known as T-cell leukemia/lymphoma 1A ( TCL1A). This gene appears to be estrogen dependent. In a study of ~300 patients with early-stage estrogen receptor–positive (ER+) breast cancer who were treated with the aromatase inhibitor (AI) anastrozole or exemestane and who developed musculoskeletal toxicity severe enough to prompt discontinuation, rs7158782(G) allele carriers were at ~2x higher risk for toxicity (CI: 1.5 - 2.9, p < 10e-6). The population attributable risk (i.e., the fraction of such adverse events that could be due to this allele) was estimated to be 11%. An editorial accompanying this article downplays the clinical utility of this finding, since testing for this allele, given its frequency and (mere) doubling of risk, has about equal odds of yielding a true positive and a false positive....
rs1800497(C;T)
A1/A2: Bad at avoidance of errors. 0.5x lower OCD risk, 0.87x lower Tardive Diskinesia risk, higher ADHD risk. More Alcohol Dependence. Lower risk of Postoperative Nausea. Increased obesity. Bupropion... The DRD2 TaqIA A1/A2 version causes less dopamine receptors. Doesn't learn from mistakes well. Reduced response to errors and increased addictive behavior Men may have half the risk of Obsessive Compulsive Disorder but higher risk of ADHD. Women have lower Persistence. 0.87x reduced risk of Tardive Diskinesia when taking dopamine receptor antagonists. Slightly increased risk of alcoholism and smoking addiction. Slower recovery from traumatic brain injury. Lower risk of postoperative nausea within 6 hours of surgery. Bupropion (Wellbutrin, Budeprion, Prexaton, Elontril, Aplenzin, Zyban, Voxra) doesn't help to quit smoking. Increased obesity due to decreased pleasure response to food. Single marker analysis the TaqIA rs1800497 and TaqIB rs1079597 variants were associated with heroin dependence....
rs9340799(G;G)
Women have 10x risk of Endometriosis, but half the risk of Endometrial Cancer and 0.76x less cognitive impairment. Men have zero risk, but can pass it on to daughters. Endometriosis means that womb tissue grows outside the womb. This SNP is a change in Estrogen Receptor 1 (alpha). It also lowers risk of cognitive impairment in aging women - on the East Boston Memory Test immediate recall test, women with this had about 1.5 to 2.0 times greater odds of remembering story elements.
rs10748045(G;G)
1.78x risk of Suicidal ideation in depression or bipolar disorder [] Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: a genome-wide association and polygenic scoring study.
gs290
You might have two short form 5-HTTLPR. You might have two short-form 5-HTTLPR (serotonin-transporter-linked polymorphic region). Variations in the region have been extensively investigated in connection with neuropsychiatric disorders. Identification of tag haplotypes for 5HTTLPR for different genome-wide SNP platforms
rs4825476(G;G)
1.9x higher risk of suicidal thoughts when taking citalopram
rs4148739(A;A)
7x less likely to respond to certain antidepressants
rs10248420(A;A)
7x less likely to respond to certain antidepressants
rs2235015(G;G)
somewhat less likely to respond to certain antidepressants
And some less PSSD specific but were flagged as important for me specifically:
rs5030868(T;T)
Homozygous/Hemizygous mutant Type II G6PD deficiency. <10% wildtype G6PD Activity. Oxidative stress induces acute hemolytic anemia.
gs308
G6PD Deficiency likely based on detection of homozygous/hemizygous mutation(s). This genoset is expected to be observed primarily in hemizygous males with a genotype containing a class I, II or III (pathogenic) G6PD deficiency-associated mutation. Individuals may be asymptomatic but should be aware of the dangers of hemolytic anemia and other adverse effects that can be triggered by certain factors and drugs. The genotype containing the specific mutation observed is listed separately in the individual's Promethease report.
Finally got my results, here are some of them:
rs6311(C;C)
(All PSSD people seem to have this one)
3.6x increased risk of sexual dysfunction when taking SSRI Antidepressants. Selective Seratonin Reuptake Inhibitors (citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac), paroxetine (Paxil), or sertraline (Zoloft)) cause worse sexual dysfunction (a common side-effect) in people with this SNP. Note that research has shown Saffron is effective at reversing the sexual dysfunction from SSRI anti-depressants.
rs7158782(G;G)
4x higher risk of adverse side-effect if taking aromatase inhibitor
rs7158782 is one of 4 SNPs found on chromosome 14 near a gene known as T-cell leukemia/lymphoma 1A ( TCL1A). This gene appears to be estrogen dependent. In a study of ~300 patients with early-stage estrogen receptor–positive (ER+) breast cancer who were treated with the aromatase inhibitor (AI) anastrozole or exemestane and who developed musculoskeletal toxicity severe enough to prompt discontinuation, rs7158782(G) allele carriers were at ~2x higher risk for toxicity (CI: 1.5 - 2.9, p < 10e-6). The population attributable risk (i.e., the fraction of such adverse events that could be due to this allele) was estimated to be 11%. An editorial accompanying this article downplays the clinical utility of this finding, since testing for this allele, given its frequency and (mere) doubling of risk, has about equal odds of yielding a true positive and a false positive....
rs1800497(C;T)
A1/A2: Bad at avoidance of errors. 0.5x lower OCD risk, 0.87x lower Tardive Diskinesia risk, higher ADHD risk. More Alcohol Dependence. Lower risk of Postoperative Nausea. Increased obesity. Bupropion... The DRD2 TaqIA A1/A2 version causes less dopamine receptors. Doesn't learn from mistakes well. Reduced response to errors and increased addictive behavior Men may have half the risk of Obsessive Compulsive Disorder but higher risk of ADHD. Women have lower Persistence. 0.87x reduced risk of Tardive Diskinesia when taking dopamine receptor antagonists. Slightly increased risk of alcoholism and smoking addiction. Slower recovery from traumatic brain injury. Lower risk of postoperative nausea within 6 hours of surgery. Bupropion (Wellbutrin, Budeprion, Prexaton, Elontril, Aplenzin, Zyban, Voxra) doesn't help to quit smoking. Increased obesity due to decreased pleasure response to food. Single marker analysis the TaqIA rs1800497 and TaqIB rs1079597 variants were associated with heroin dependence....
rs9340799(G;G)
Women have 10x risk of Endometriosis, but half the risk of Endometrial Cancer and 0.76x less cognitive impairment. Men have zero risk, but can pass it on to daughters. Endometriosis means that womb tissue grows outside the womb. This SNP is a change in Estrogen Receptor 1 (alpha). It also lowers risk of cognitive impairment in aging women - on the East Boston Memory Test immediate recall test, women with this had about 1.5 to 2.0 times greater odds of remembering story elements.
rs10748045(G;G)
1.78x risk of Suicidal ideation in depression or bipolar disorder [] Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: a genome-wide association and polygenic scoring study.
gs290
You might have two short form 5-HTTLPR. You might have two short-form 5-HTTLPR (serotonin-transporter-linked polymorphic region). Variations in the region have been extensively investigated in connection with neuropsychiatric disorders. Identification of tag haplotypes for 5HTTLPR for different genome-wide SNP platforms
rs4825476(G;G)
1.9x higher risk of suicidal thoughts when taking citalopram
rs4148739(A;A)
7x less likely to respond to certain antidepressants
rs10248420(A;A)
7x less likely to respond to certain antidepressants
rs2235015(G;G)
somewhat less likely to respond to certain antidepressants
And some less PSSD specific but were flagged as important for me specifically:
rs5030868(T;T)
Homozygous/Hemizygous mutant Type II G6PD deficiency. <10% wildtype G6PD Activity. Oxidative stress induces acute hemolytic anemia.
gs308
G6PD Deficiency likely based on detection of homozygous/hemizygous mutation(s). This genoset is expected to be observed primarily in hemizygous males with a genotype containing a class I, II or III (pathogenic) G6PD deficiency-associated mutation. Individuals may be asymptomatic but should be aware of the dangers of hemolytic anemia and other adverse effects that can be triggered by certain factors and drugs. The genotype containing the specific mutation observed is listed separately in the individual's Promethease report.
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