Understanding The Possible Mechanisms of Hair Loss

TubZy

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ARL : Hair Loss, A Growing Concern

Introduction
Hair loss or alopecia is a common and embarrassing problem for many people. Catherine the Great, empress of Russia from 1762 to 1796, suffered from this problem and had to wear a wig. She was so fearful of gossip that she kept her hairdresser confined in an iron cage in her room for three years.


There are many reasons why hair loss occurs, including nutrient excesses and deficiencies, impaired circulation and hormonal imbalances. Let us begin by describing the structure and growth of hair.


The Structure Of Hair
Hair is a connective tissue composed of strands of protein. These are linked, or cross linked in various ways. The type of cross linking makes some individual's hair straight, while others are curly, waved, or kinky. (Permanents alter the cross linking of hair proteins.) The particular protein structure determines the health as well as the appearance of the hair.


The hair follicle goes through three different growing phases called anagen, catagen and felogen phases. If certain nutrients are deficient during any one of these phases, hair loss may occur.


Individual Nutrients And Hair Loss
Zinc and RNA Transferase
Zinc is required for RNA (ribonucleic acid) transferase; an enzyme involved in DNA (deoxyribonucleic acid) synthesis, or synthesis of all body proteins. Impairment of zinc metabolism will affect all protein structures of the body. Zinc is also required for synthesis of carboxypeptidase; a digestive enzyme required for digestion of dietary protein.


Copper and Lysyl Oxidase
Lysyl oxidase is a copper-dependent enzyme involved in connective tissue synthesis. Copper imbalance often leads to lackluster hair and hair loss. Excessive copper, by interfering with the sulfide bonds in the hair, literally causes a dissolution of the hair structure. This may cause certain individual's hair not to hold a permanent.


Copper is also required for tyrosinase; an enzyme required for melanin production. Melanin is a pigment substance which gives color to the hair.


B-Complex Vitamins
Many hair products contain B-complex vitamins, especially vitamin B6, PABA and biotin. These vitamins are involved with amino acid metabolism. Amino acids are the building blocks from which proteins are constructed.


Mucopolysaccharides
Mucopolysaccharides are a group of connective tissue compounds that have been found helpful to the growth of hair. Their synthesis depends on the bio-availability of copper and other nutrients.


Male Hormones
It has been noted that excessive male hormone levels can cause 'male pattern' hair loss in both men and women. Balancing body chemistry can often balance these hormone levels and restore hair growth.


Protein Deficiency
A protein deficiency is a well-known cause of hair loss. Protein deficiency causes a reduction in the linear rate of growth in the hair and in the diameter of the hair shaft, which causes the hair to shed easily. Poor digestion and utilization of protein can cause hair loss even if one's protein intake is adequate.


Other Important Nutrients
Deficiency of sulfur, vitamin B6 and B12 have also been shown to cause hair loss. Exceedingly high dosages of vitamin A can also cause hair loss.


Body Chemistry And Hair Loss
Fast Oxidation
Fast oxidizers have elevated sodium levels. Sodium is eliminated in part through the skin and hair. You may notice a salty taste to your skin if you are a fast oxidizer.


The first inch or two of the hair represents a section of active growth where minerals can be stored and called upon during stressful periods. As sodium accumulates in the tissue, it can 'petrify' the hair follicle resulting in hair loss.


Fast oxidizers are also prone to a deficiency of copper and zinc, which may contribute to hair loss. Excessive male hormone production by the adrenal glands is also associated with a fast oxidation rate.


Fast oxidizers have low glycogen reserves and commonly convert some of their body protein to sugar to burn as fuel. Thinning hair in fast oxidizers can be due to the breakdown of hair protein for fuel. A loss of the hair protein is much better than loss of protein from vital organs and tissues.


Slow Oxidation
Hair loss in slow oxidizers is associated with excess, or bio-unavailable tissue copper. A copper imbalance causes a dissolution of the hair structure, resulting in impairment of hair growth and 'lifeless' hair.


An excess of tissue copper also contributes to low sodium levels in slow oxidizers. When the tissues are low in sodium, transport of vital nutrients into the hair follicle is impaired. When nutrients cannot be transported into the hair cells, hair loss will eventually occur.


An elevated copper level and/or adrenal exhaustion also causes calcium accumulation in the soft tissues of the body, including the hair. Calcium accumulation impairs transport across cell membranes, impairing the flow of nutrients to the hair.


Slow oxidation is also associated with sluggish thyroid activity, which is known to be associated with hair loss.


Blood pressure is often low in the slow oxidizer and circulation poor due to impaired adrenal and thyroid activity. Blood circulation to the scalp may be impaired, contributing to hair loss.


Hypothyroidism and Hair Loss
The alopecia of hypothyroidism is well known. Thinning of the hair is one of the recognized signs of low thyroid activity. On a hair analysis, high calcium is an indicator of lowered thyroid activity.


Pregnancy and Hair Loss
Loss of hair frequently occurs in a woman just after delivering a child. The accumulation of copper during pregnancy depresses the thyroid gland, which will result in hair loss.


Low Hair Sodium-to-Potassium Ratio
A sodium-to-potassium ratio on a tissue mineral test below 2.5:1 is indicative of protein breakdown. Potassium is released from cells, causing the potassium level to rise relative to sodium. Since hair is a protein structure, excessive protein breakdown can cause hair loss.


Stress and Hair Loss
Frequently, hair loss occurs directly following a stressful situation. Stress can be physical, such as an illness or chemotherapy, or it may be mental, or emotional. Reasons for hair loss resulting from stress are;


  • stress causes rapid zinc depletion,
  • in fast oxidizers, copper is lost also under acute stress,
  • in slow oxidizers, copper can become bio-unavailable due to stress,
  • stress can impair blood circulation to the scalp,
  • stress impairs protein digestion and utilization,
  • stress increases the demand for many "B" vitamins, which can lead to a deficiency.

Chemotherapy and Hair Loss
Certain cytotoxic drugs used in cancer chemotherapy result in hair loss. We have observed a reduction of hair loss in those persons undergoing chemotherapy when supplementary nutrients are given along with the chemotherapy. This leads us to suspect that the loss of hair associated with chemotherapy may be due to nutrient deficiencies, or imbalances, induced by the drug therapy.


Conclusion
Through a deeper understanding of the role of nutrients and metabolic balance in hair growth, it is often possible to prevent and even reverse the troubling symptom of hair loss.
 

Potion

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More than three quarters of white men I have seen that have at least 50/50 salt-and-pepper hair (silver foxes) have nearly no hair loss. I met such a man yesterday, and there is such a man ten meters from me right now: he is fifty years old, went salt-and-pepper at thirty, and has absolutely zero hair loss on his entire scalp; his hairline is immaculate and so dense it crowds his forehead. I have looked through the labs of both men and have found nothing outstanding. I can't recall the distribution of dark and light hairs in all such men I've encountered, but yesterday's man and today's man are both about 75% light hairs, with the residue being black or dark gray. The man yesterday eats all manner of foods, the predominance being red meat (he said he's a farm boy who eats also a lot of vegetables). The man here now is in a methadone drug rehab program; he too eats a lot of vegetables, but eats TV dinners every night. Both men enjoy the cruciferous vegetables, each mentioning broccoli and cauliflower. Broccoli is a known hyperaccumulator of selenium.

Why this remarkable association? I have seen many men with this feature. I am so confident in this correlation, I would bet great sums of money there is a definitive, mutual causation. Whatever leads to the change in their hair color is protecting them from gross alopecia.

Has anyone else noticed the same?
 

Aleksandr

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1,285
More than three quarters of white men I have seen that have at least 50/50 salt-and-pepper hair (silver foxes) have nearly no hair loss. I met such a man yesterday, and there is such a man ten meters from me right now: he is fifty years old, went salt-and-pepper at thirty, and has absolutely zero hair loss on his entire scalp; his hairline is immaculate and so dense it crowds his forehead. I have looked through the labs of both men and have found nothing outstanding. I can't recall the distribution of dark and light hairs in all such men I've encountered, but yesterday's man and today's man are both about 75% light hairs, with the residue being black or dark gray. The man yesterday eats all manner of foods, the predominance being red meat (he said he's a farm boy who eats also a lot of vegetables). The man here now is in a methadone drug rehab program; he too eats a lot of vegetables, but eats TV dinners every night. Both men enjoy the cruciferous vegetables, each mentioning broccoli and cauliflower. Broccoli is a known hyperaccumulator of selenium.

Why this remarkable association? I have seen many men with this feature. I am so confident in this correlation, I would bet great sums of money there is a definitive, mutual causation. Whatever leads to the change in their hair color is protecting them from gross alopecia.

Has anyone else noticed the same?
Are you a doctor?

Ive noticed emotional type men and men who seem like fast oxidisers tend to have less hairloss. One i know of hasnt had sex in the last 12 months, he's 55 with a perfect hairline and grey hair. Slightly thinning maybe on top but its barelt noticable. I could be wrong. The Harline is untouched.

Seems like this guy would have decent zinc stores since he doesn't have sex, and maybe low copper since he's definitely a fast oxidiser. Also maybe low copper causes greying.

Btw i think maybe fast oxidisers like me who are fast through exercise can maybe suffer from diffuse thinning since we often have low protein.

I think you need a few things to avoid hairloss:
No excess copper
Plenty of zinc and protein (to make the hair, avoids diffuse thinning)
Not too much calcium, and higher magnesium than calcium (this improves blood flow and stops calcification i.e pattern baldness)
 

brix

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593
Are you a doctor?

Ive noticed emotional type men and men who seem like fast oxidisers tend to have less hairloss. One i know of hasnt had sex in the last 12 months, he's 55 with a perfect hairline and grey hair. Slightly thinning maybe on top but its barelt noticable. I could be wrong. The Harline is untouched.

Seems like this guy would have decent zinc stores since he doesn't have sex, and maybe low copper since he's definitely a fast oxidiser. Also maybe low copper causes greying.

Btw i think maybe fast oxidisers like me who are fast through exercise can maybe suffer from diffuse thinning since we often have low protein.

I think you need a few things to avoid hairloss:
No excess copper
Plenty of zinc and protein (to make the hair, avoids diffuse thinning)
Not too much calcium, and higher magnesium than calcium (this improves blood flow and stops calcification i.e pattern baldness)
I’m a fast oxidizer copper hurts my hair more than zinc.
 

Ivy

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@TubZy, wouldn't it be beneficial to add the two types of hairloss and the distinct approaches they call for, according to gbolduev? That info is scattered all over his old quotes. I'm also not absolutely sure he still subscribes to his original dichotomy of fast oxidation/protein wasting vs slow oxidation/aga. The latest version seemed to be protein wasting vs connective tissue degradation.

An update of his insights would be extremely helpful.
 

JDreamer

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55
I'm constantly re-tracing my steps as to when the my hair loss problem really began. It always points back to stress and digestion.

After working myself to the bone and living off energy drinks circa 2003-2005, I became violently ill. It took me 2-3 weeks to recover, as well as for a nasty gumline infection near a wisdom tooth to clear up. Ever since that day my digestion has been extremely poor - inconsistent pale stools (fluctuating between constipation/diarrhea), bloating, and eventually burping (started in 2014 when my hairline recession excellerated).

Keep in mind I've also been a very active workout guy, which puts major stresses and nutrient requirements on my body - especially now that I focus so hard on compound movements (i.e. squats, dead lifts, etc). I can't even imagine how poor my ability to absorb digest/proteins has been. I can tell because I lose my muscle gains so quickly - which I assume is in part to my body cannibalizing it for fuel. I could also tell I was having issues because of an ammonia like smell in my sweat during workouts. I ditched the protein supplements I was drinking - smell is gone, but now I imagine my body is getting even less than it needs.

I'm sure I also compounded matters when a few years ago I completely cut out carbs and sugars to try and fix my bloating issues. I was probably getting no more than 60% of the caloric intake my body was starving for. I'm not going to lie, I still struggle with that because of my stomach issues and my work schedule.

There's a lot of wisdom on this site and intriguing supplement regimens ......... but I don't want to be so dependent on pills/powders. I need to fix my gut. I've even read a poor gut also causes serotonin to get out of control, which would explain some of the cognitive/mental issues I notice sometimes.
 
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Scenes

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88
So @TubZy isn’t the same theory for hair as for everything else right now?

Eat protein and kale/spinach
Add liquid hcl diluted
After a little while add gelatin as well

Is that too simplistic a summary?
 

TubZy

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So @TubZy isn’t the same theory for hair as for everything else right now?

Eat protein and kale/spinach
Add liquid hcl diluted
After a little while add gelatin as well

Is that too simplistic a summary?

It honestly depends really.

What you described is basically electrolyte protocol, which can help balance your body in general through providing your body the ability to retain minerals and aminos again. Although, getting a hair test first would be the first priority. To at least understand, zinc versus copper ratio along with any toxicities in terms of hair.

But to your point, yes it pretty much the same theory, this thread just outlines it in a more detailed way.
 

TubZy

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@TubZy, wouldn't it be beneficial to add the two types of hairloss and the distinct approaches they call for, according to gbolduev? That info is scattered all over his old quotes. I'm also not absolutely sure he still subscribes to his original dichotomy of fast oxidation/protein wasting vs slow oxidation/aga. The latest version seemed to be protein wasting vs connective tissue degradation.

An update of his insights would be extremely helpful.

I can see what I can gather, it will take me a bit though, still trying to smooth out the site.

What you are talking about, he talks in this thread (his quotes) you can just use control + F and search for what keywords you are looking for. For example, the protein wasting hair loss is in that thread.

Gbolduev's Summary of Quotes & Ideas (all topics)
 

Aleksandr

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1,285
So @TubZy isn’t the same theory for hair as for everything else right now?

Eat protein and kale/spinach
Add liquid hcl diluted
After a little while add gelatin as well

Is that too simplistic a summary?
Dont forget the electrolytes which seem to be rec'd mostly from food now; potassium, magnesium and in some cases (like athletes) sodium from salt. Water is also a big one for athletes

BTW ive found slow cooked meat (4+ hours cooked in water) the absolute best protein to digest. You want it so its like falling apart in your mouth. Then add tomato paste for potassium.
 

Scenes

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Messages
88
Dont forget the electrolytes which seem to be rec'd mostly from food now; potassium, magnesium and in some cases (like athletes) sodium from salt. Water is also a big one for athletes

BTW ive found slow cooked meat (4+ hours cooked in water) the absolute best protein to digest. You want it so its like falling apart in your mouth. Then add tomato paste for potassium.

Gbold used to say that the whole goal is to get potassium in the cell, but you can’t do that by eating/supplementing more potassium.

Then he introduced supplementing potassium alongside copper, to avoid copper crashing the thyroid.

Now it seems it’s just eat all the good foods (proteins and super foods like kale and electrolytes and brewers yeast and gelatin) and take hcl to make sure they digest properly.

When people asked if we could just eat well and take hcl weeks ago gbold said no, it’s not that simple.

Can anyone comment on this change? Have I missed anything?
 

Aleksandr

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1,285
Going to need your recipes here man ;)
Buy the cheapest cut you can get. Chuck stake etc is usually pretty good. Or even a roast. Just the cheapest per kg price with no bones.


Put it in a pot with fat, brown the outside on high heat, then pour water in so its all submerged. Then put the lid on, put on low heat. Let it cook for 4+ hrs.

Then take the lid off when youre ready to eat, put on high heat so the water boils down, and eat when all the water is boiled out. You need to watch it for this last part so it doesn't burn.



Man... so delicious. The meat should just fall apart on your fork. I've been having it with tomato paste (lots of potassium) and spinach. Usually just in bread like a burger. I pop 1 hcl capsule before the meal too.
 

Aleksandr

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Messages
1,285
Gbold used to say that the whole goal is to get potassium in the cell, but you can’t do that by eating/supplementing more potassium.

Then he introduced supplementing potassium alongside copper, to avoid copper crashing the thyroid.

Now it seems it’s just eat all the good foods (proteins and super foods like kale and electrolytes and brewers yeast and gelatin) and take hcl to make sure they digest properly.

When people asked if we could just eat well and take hcl weeks ago gbold said no, it’s not that simple.

Can anyone comment on this change? Have I missed anything?
I think all of gbolds stuff is just actively developing, so he changes his mind.

The solid things we have right now which wont seem to change:

Eat well
Eat foods to balance your lifestyle (like athlete-specific, or sedentary specific)
Get a hair test and follow your ARL supplements for a few months
 

TubZy

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Staff member
Messages
2,590
Gbold used to say that the whole goal is to get potassium in the cell, but you can’t do that by eating/supplementing more potassium.

Then he introduced supplementing potassium alongside copper, to avoid copper crashing the thyroid.

Now it seems it’s just eat all the good foods (proteins and super foods like kale and electrolytes and brewers yeast and gelatin) and take hcl to make sure they digest properly.

When people asked if we could just eat well and take hcl weeks ago gbold said no, it’s not that simple.

Can anyone comment on this change? Have I missed anything?

I honestly don't want to speak for him in this instance, so I will tag him. @gbolduev

Have you got a hair test yet @Scenes ?
 

brix

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Messages
593
I haven’t done a hair test yet but what do y’all think about hair loss that occurs on top/sides/back of head equally? My scalp is loose with no calcification.
 

JDreamer

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Messages
55
I thinks few people were, although I forget who. Someone did have decent success with polysorbate, I think it was @JDreamer
What about the sea-salt rubbing and Polysorbate-80 thing, is anyone still trying it?

I'm still using the Polysorbate 80. Some things to note:

- The scalp acne is still gone
- Circulation on the top is noticeably better. I honestly have only dermarolled my scalp 2-3 times in the last four months, but each time I did it there was significantly more blood than what I remembered.
- I've maintained my crown. Granted, it's still thin in the back, but I haven't lost any ground.
- After not seeing any recession in the front - it has suddenly reared its ugly head again
- Doesn't seem to straighten my hair as well as it used to

Most importantly, there's been no regrowth and my hair has been extremely dry lately. The tick up in hairline recession has me very concerned. I'm wondering if my scalp is too dry and perhaps it's part of the problem. Keep in mind, not only do I use the P80 - I then wash it out with a Tea Tree-based shampoo before conditioning and then styling (I blow dry my hair and commonly use a flatiron). I know for a fact my sebaceous glands were working overtime prior to P80, due to how oily everything would get up there. Is a little bit of oil excretion necessary for healthy hair growth?

During the last four months I've also ditched protein supplements and have experimented with Aminos, as well as some Milk Thistle (for what I believe is a congested liver). I use Modern BCAA, as well as an extra 2000mg of Taurine, and some Vitamin C. My hair was doing a bit better when I was trying to increase dopamine, but the problem was I also felt too agitated on that protocol.

One more thing - I always feel a ton of pressure in my forehead and temples of my scalp. It's like it can never relax up there.
 
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ballheadbuddha

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Messages
86
One more thing - I always feel a ton of pressure in more forehead and temples of my scalp. It's like it can never relax up there

Always had this feeling.. what I think is having a impact on maintaining my hair is vigorously knuckle-massaging my scalp, it's incredible how my scalp feels more flexible and less tight than before.
I'm still shedding and having scalp-aches, but less.