Quercetin inhibits the expression and function of the androgen receptor

[IHateFin]

after a lot of talk in the upregulated androgen thread by Helen i was looking into saw P to cure this shit once n for all and i stumbled on to this:

Cure PFS and Accutane Side Effects

actually i think @PFStinks linked this on another thread, but something said in it stuck out to me "This is why I included quercetin in the protocol since it has potent androgen receptor downregulating abilities"
i had no idea quercitin had this ability so i looked it up and found this:

Anti-androgenic effects of flavonols in prostate cancer

"Myricetin, quercetin, and fisetin have a catechol or pyrogallo configuration in the B-ring which may allow them to inhibit 5α-reductase isoenzyme 1,
Quercetin has been shown to compete with testosterone at high concentrations. However, the concentrations are higher than needed for cell growth inhibition, suggesting that this is unlikely to be its main cytostatic mechanism [30]. Another study found that quercetin increases serum testosterone, and after an initial rise, decreases DHT in a dose-dependent manner in a rat model."

Quercetin inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells. - PubMed - NCBI

Suppression of the androgen receptor function by quercetin through protein-protein interactions of Sp1, c-Jun, and the androgen receptor in human p... - PubMed - NCBI

"hese results suggested that c-Jun might play an important role in the suppression of AR expression and activity in the presence of quercetin, and association of a c-Jun/Sp1/AR protein complex induced by quercetin represented a novel mechanism that was involved in down-regulation of the AR function in prostate cancer cells."

this is interesting since quercitin is healthy for us and maybe could be something that can be loaded to see if any relief is felt from PFS. i assume this would only work for those who feel good when DHT is reduced.. meaning that that person has a pfs type where their recptors are either silenced or heavily upregulated... i have a feeling androgen receptro silencing is more so the issue than androgen receptor upregulation... ooooor it could be that they are in fact upregulated and thus a lot of them have been silenced due to that. who knows, but i think i want to try taking a lot of quercitin to see what happens.


what do you think @Helen

 

[Helen]

Ihatefin, buddy, you dont know which case you are , upregulated or downregulated.

 

[HerrFisch]

Looks like Histamine is involved in Androgen receptor up / downregulation?
I think I read Antihistamines can be antiandrogenic

 

[Helen]

I remember I took quercetin for a while when I was still really sick., it made me very strong and remember I was swimming in the sea like crazy. I think it was the first supplement that worked for me

 

[IHateFin]

Ihatefin, buddy, you dont know which case you are , upregulated or downregulated.

Not exactly, but I know that increasing dht or 5AR makes me feel worse and that some things that decrease make me feel good even tho it's usually only temporary.

I know for a fact that many of my receptors are silenced or upregulated to the point of silencing because when I actually heal new hairs sprout on face and hands and forearm. When that happens I feel great for a few days then it tapers off signifying that my body gets hit with new androgens in new receptor sites then body re-adjusts to a new homeostasis which is still a heavily silenced state and thus I'm at a better baseline, but still nothing special.

 

[PFStinks]

Not exactly, but I know that increasing dht or 5AR makes me feel worse and that some things that decrease make me feel good even tho it's usually only temporary.

I know for a fact that many of my receptors are silenced or upregulated to the point of silencing because when I actually heal new hairs sprout on face and hands and forearm. When that happens I feel great for a few days then it tapers off signifying that my body gets hit with new androgens in new receptor sites then body re-adjusts to a new homeostasis which is still a heavily silenced state and thus I'm at a better baseline, but still nothing special.

You should send an email to the guy that runs that blog or get in contact with him some other way and drag him to these forums.
Apparently he stopped experimenting with quercetin and now he's experimenting with "soy and saw palmetto (whole herb NOT extract)"
Although he said quercetin might still be useful.

 

[joekool]

Berberine Suppresses Androgen Receptor Signaling in Prostate Cancer

This shows berberine has a slightly similar effect but only on the prostate.

 

[Troy]

Berberine Suppresses Androgen Receptor Signaling in Prostate Cancer

This shows berberine has a slightly similar effect but only on the prostate.

Interesting. So berberine made me worse and quercitin whilst not as strong I think made me worse too by lowering estrogen.

I must need to increase my receptors.

But why then did potassium ultimately help me ? @Helen

 

[bruschi11]

@Cdsnuts used quercetin during his recovery for a bit.

Could you explain bud?!

 

[MNK99]

I may go thru later perhaps and draw conclusions... but that may be difficult:

Some articles on "quercetin":
1.
Acne vulgaris treatment regimen
BE Guthery - US Patent 8,679,552, 2014 - Google Patents

… In another embodiment, the 5AR inhibitor of the formulation of the invention comprises
(−)catechin-3-gallate, (−)epicatechin-3-gallate and … Other flavonoids that are potent inhibitors of
the type-1 5 alpha-reductase include myricetin, quercitin, baicalein, fisetin, alizarin, anthrarobin …
Cited by 16Related articlesAll 4 versions

2.
[PDF] Comparative evaluation of a modified acetic method for extraction of antioxidant compounds from black beans (Phaseolus vulgaris)
JF Islas, AJ Dávalos-Balderas… - Food and Nutrition …, 2012 - researchgate.net
… More- over, related flavonols like Myricetin, Quercitin and Kamp- ferol may act through antioxidant,
prooxidant, antiestro- genic, cell signaling … [5] AR Ness and JW Poulens, “Fruit, Vegetables, and
Cardiovascular Disease: A Review,” International Jour- nal of Epidemiology, Vol …

Cited by 2Related articlesAll 9 versions

3.
[PDF] Phyto-constituents as a lead moieties for alzheimer's: a mini review
NSS Chalichem, TK Praveen, M Chaitanya… - Indo Am J …, 2016 - researchgate.net

… Constituent Plant name / Family Possible MOA Induction agent Refer- ence through inhibition
of phosphorylations Quercitin Wide distribution In triple transgenic AD mice (3XTg) it was proved
to decreases β-amyloidosis and Tauopathy at 25 mg/kg dose, ip Transgenic [42] …
Cited by 1Related articlesAll 3 versions

4.
Can a microbial fuel cell resist the oxidation of Tomato pomace?
A Fogg, V Gadhamshetty, D Franco, J Wilder… - Journal of Power …, 2015 - Elsevier

 

[MNK99]

Some more articles on "quercetin" + "5ar":
1.
The facile formation of trioxanaphthacenes by a [4+ 2] addition of flavonols to 1, 2-benzoquinone
J Kaizer, G Speier, E Ősz, M Giorgi, M Réglier - Tetrahedron letters, 2004 - Elsevier

… Quercetin is one of the most abundant natural flavonoids in edible fruits and vegetables … The
X-ray single-crystal structure of 5a (5aS,11aS and 5aR,11aR diastereomers) was determined,
14 and its computer-generated drawing is shown in Figure 1. The structural determination …
Cited by 5Related articlesAll 5 versions

2.
Purification and catalytic properties of a tetrameric carbonyl reductase from rabbit heart
Y Imamura, T Migita, M Otagiri… - The Journal of …, 1999 - academic.oup.com

… and loxoprofen) or steroids (4-andro- stene-3,17-dione, 5a-androstane-3,17-dione, 5y3-andro-
stane-3,17-dione, Sff-androstan-l^/J-ol-S-one, 5ar-andro- stan-3«-ol … Flavonoids (quercetin and
quer- citrin), well-known inhibitors of carbonyl reductase, strongly inhibited the enzyme …
Cited by 26Related articlesAll 13 versions

4.
Prostate cancer: a serious disease suitable for prevention -what @joekool was referring to perhaps. --SIMILAR to the 2 studies you guys posted. @IHateFin
JM Fitzpatrick, C Schulman, AR Zlotta… - BJU …, 2009 - Wiley Online Library

… Reducing the risk of prostate cancer has gained increasing coverage in recent years,
with proof of principle shown in the Prostate Cancer Prevention Trial with the type
2 5α‐reductase (5AR) inhibitor, finasteride … 5AR INHIBITORS …

Cited by 51Related articlesAll 10 versions

5.
Managing Men's Health
R Rowe - Journal of Complementary Medicine: CM, The, 2009 - search.informit.com.au

… preclinical study found that saw palmetto inhibits the activity of human prostate-cancer cells but,
unlike pharmaceutical 5AR inhibitors, does … extracts of Serenoa repens in renoa repens
combination with nettle (Urtica dioica), curcumin (Curcuma longa) and quercetin were found …
Related articles

6.
Phytochemical investigation and hyphenated chromatographic analysis of bioactive lupeol and stigmasterol in Sespadula by validated high-performance thin layer …
M Hussain, S Fareed, M Ali… - International Journal of …, 2012 - search.ebscohost.com
… is only available regarding the analytical methods for the qualitative and/or quantitative estimation
of lupeol (LP; 1R, 3aR, 5aR, 5bR, 7aR, 9S … The absorbance of the mixture at 510 nm was measured
immediately in comparison to a standard curve prepared using quercetin …
Cited by 9Related articlesAll 3 versions

7.
[PDF] Phytochemical Investigations on Caragana Ambigua

 

[IHateFin]

You should send an email to the guy that runs that blog or get in contact with him some other way and drag him to these forums.
Apparently he stopped experimenting with quercetin and now he's experimenting with "soy and saw palmetto (whole herb NOT extract)"
Although he said quercetin might still be useful.

I might have to see if I could reach out, but I don't like soy at all... maybe quarcitin and saw p would be better..
I once took saw p for a few days before fin and it did nothing to me.. although I did have a huge spike in libido when I hopped off but could also have been a coincidence.

 

[Area-1255]

Looks like Histamine is involved in Androgen receptor up / downregulation?
I think I read Antihistamines can be antiandrogenic

Antihistamines like Cimetidine (Tagamet) - although H2-antagonists; that is, antacids/Anti-Acid pills. For stomach acid/GERD/Acid Reflux. These are anti-androgenic. But that's unique to those drugs "other" properties. Has NOTHING to do with Histamine. With that being said, Histamine H2R's stimulate cyclic AMP (cAMP) - which, like Forskolin (but to a Greater Degree) increases Androgen Receptors, and Testosterone Synthesis.

 

[IHateFin]

Antihistamines like Cimetidine (Tagamet) - although H2-antagonists; that is, antacids/Anti-Acid pills. For stomach acid/GERD/Acid Reflux. These are anti-androgenic. But that's unique to those drugs "other" properties. Has NOTHING to do with Histamine. With that being said, Histamine H2R's stimulate cyclic AMP (cAMP) - which, like Forskolin (but to a Greater Degree) increases Androgen Receptors, and Testosterone Synthesis.

Dang good find! It's no wonder histidine helps so much, but maybe it's not the best to take if one is trying to lower dht.. guess it depends on which type of PFS you find yourself.

Although histidine seems to help me, but I'll have to cut it out for a tad n see what happens.
Might dose some quercitin tomorrow.

 

[Area-1255]

Dang good find! It's no wonder histidine helps so much, but maybe it's not the best to take if one is trying to lower dht.. guess it depends on which type of PFS you find yourself.

Although histidine seems to help me, but I'll have to cut it out for a tad n see what happens.
Might dose some quercitin tomorrow.

Use Lactobacilus Rhamnosus Probiotics...they downregulate the Histamine H4-Receptor [STUDY] which normally STOPS/INHIBITS Testosterone/Testicular Function [STUDY]. Use it long-term, then L-Histidine only hits the H1/H2/H3. If you block H3 too, with Kutaj/Conessine. Then you get only H1/H2 activation - thus you get TOTAL whole-body Histaminergic-stimulation. I'd warn you though. That could be a Recipe for an uncontrollable sex-binge. Something you might Regret later, heheheheh. @Helen

 

[IHateFin]

Use Lactobacilus Rhamnosus Probiotics...they downregulate the Histamine H4-Receptor [STUDY] which normally STOPS/INHIBITS Testosterone/Testicular Function [STUDY]. Use it long-term, then L-Histidine only hits the H1/H2/H3. If you block H3 too, with Kutaj/Conessine. Then you get only H1/H2 activation - thus you get TOTAL whole-body Histaminergic-stimulation. I'd warn you though. That could be a Recipe for an uncontrollable sex-binge. Something you might Regret later, heheheheh. @Helen

Sex binge eh? Sounds like something I'd rather enjoy actually haha

 

[jacknap]

I use the rhamonisis rheuteri poweder from now foods. got my ball size back to normal. cant say it helps my libido though.

there are a lot of different strains of it. not sure if they all act the same

 

[Chapman]

You should send an email to the guy that runs that blog or get in contact with him some other way and drag him to these forums.
Apparently he stopped experimenting with quercetin and now he's experimenting with "soy and saw palmetto (whole herb NOT extract)"
Although he said quercetin might still be useful.

I think this is Ihatefin88 on solvepfs' blog.

 

[tanedout]

Been taking 3 x 200mg of quercetin daily for a few months, basically due to its anti inflammatory properties, but can’t say I’ve really noticed much from it. I did run out for a week or two, and there was no snap back or anything in that period.

Might require high doses for the effects being discusssed here

 

[IHateFin]

I think this is Ihatefin88 on solvepfs' blog.

its not lol im not ihatefin88 nor am i ihatefin from propecia help haha im a different ihatefin