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To get back to this and your comment about ER overexpression. It could very well be so - upregulated ER but the transcription (binding of ER to ERE) can't happen properly. Just like when Helen talked about binding AR to ARE. Now the question is what to do about this if it is the case. Post AI...

Hey man, thanks a lot for this informative reply. This is quite interesting. My TSH levels border on hypo. I might actually be somewhat hypothyroid. Mind you, I'm a fit guy, always was. Could hardly gain weight. Muscles much easier, though (at least that's how it used to be; after crashing I've...

I was considering this as well but I'm not sure if this is the case for arimidex, it being a nonsteroidal inhibitor which is known for its rebound effect. So after inhibiting aromatase this would prompt the body to upregulate ER, aromatase and decrease SHBG to free up some testosterone that...

If you'll ever get to it - I'd definitely love to read what you came up with!

Yes, man, the vaccines can be quite horrifically unpredictable in their effects. And this is coming from someone that is reasonably pro-vax. It's just that one cannot ignore thousands of people that got seriously hurt by vaccines. In the discord server in my comment above there's a lot of folks...

I'm being a bit of a drama queen. I guess justifiably so considering all the horror stories of AI crashes I've read. Thanks for your words of encouragement. I'll do an OAT soon. And HTMA too. I'm just not sure how much TRT affects the markers so I'm holding off a bit. These tests cost shitload...

Oh, great, I see you joined. There's a lot of information there - a labyrinth of it, actually, but I think you'll be familiar with many things. The overall model seems to dovetail in many places with what Helen was proposing. But it's more focused on the infection aspect and how it induces a...

Hey man, I've discovered this place just few weeks ago. I'm learning a lot, especially from Helen. And you as well. I also found this discord server: https://discord.gg/PkW5mCvn If you don't know it yet I urge you to join. Many really knowledgeable people are there and they might help you. I...

This is obviously an older thread but I suppose I'll comment anyways. For the sake of our descendants, heh. This has been my experience as well after crashing my E2 with aromasin while natty (foolish, I'm aware). Unfortunately, it's now months after the crash and I still haven't recovered. So I...