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Guys I have a theory about PFS: I think that people who get PFS side effects are all copper deficient. My reasoning is the following: Copper is the strongest 5AR inhibitor in the human body and also controls iron. https://www.jidonline.org/article/S0022-202X(15)42127-X/pdf What happens if...

@Helen Is it possible for cells to get stuck in a high potassium state when hormones are low? And could this lead to thiamine depletion because there is very high sugar oxidation inside the cell (high intracellular CO2). So no thiamine -> no NADPH -> AR/GR get upregulated to the max to try to...

Trees cannot solve this problem in less than a few thousand years. The mathematics is simple. The human civilization has depended on oil, coal and natural gas for energy production for the last 200 years. Those three are hydrocarbons which are the product of photosynthesis (CO2 + H20 + sunlight...

I wouldn't say physical activity correlates with ventilation unless you force yourself to breath out. If your acetylcholine is high and it is inhibiting your autonomic breathing drive, CO2 levels will go up with exercise not down. When I eat a lot of pineapple the manganese stops acetylcholine...

If you are the opposite case (alkalosis with low CO2) taking vitamin K would be very bad idea.

@Nina I could be wrong here but it sounds to me like you have a vitamin K deficiency. You say you get bruises easily and you have a narrow lower jaw which are pretty obvious symptoms. What vitamin K does in the body is carboxylation. This is the process of integrating CO2 into proteins in order...

This is from low histamine. I am sure. Helen talked about it and it matches my experience. The less histamine you make the more your receptors become sensitive to it so during sexual stimulation it makes you come crazy fast. Either copper is breaking it down too much or synthesis is low (b2/b6...

I fully agree with you there. It is a pitfall that many men fall into once they start reading TRP. They adopt this pump-and-dump mindset towards women which benefits neither women neither men in the long run. But this is a problem with morality and integrity. The theory in itself is amoral. How...

I've been reading TRP for 7 years already and right from its inception it has never really been about manipulating women. It has always been about building yourself to be a better man. Just like this forum. Exposing the workings of female instincts and biology is just a necessary part of it. To...

Nice post @HerrFisch I agree zinc/manganese should be the core focus of most people with copper problems. I was low in both of them but couldn't take any zinc until my manganese levels got up. One is crucial for the other. At least in my case when I eat a pineapple or take manganese my...

heavy metals from the mother/ imbalanced dietary mineral ratios / b vitamins drain / pollution / amalgams / high PUFA pressuring antioxidant status

Easy to answer, not easy to solve lol. low NADPH production -> low androgens + low vitamin K recycling + low vitamin K induction by androgens. You cant fix it by giving vitamin K because it will lower already low NADPH and kill ionized calcium -> alkalosis. Pretty much everything else has to be...

Very nice. I'm surprised you were able to take so much manganese for so long. How much do you think it helped you?

It's going down pretty fast.

Maybe you need some more arginine to bind the extra manganese?

You said you did 75mg of manganese for a while? Maybe this inhibited 3beta-HSD too much and you retained zinc, b2 and b6 to make progesterone? So now they are making a lot of histamine and you get too much acidity in your stomach and too much intestinal movement. Manganese also inhibits...

@Nina Wild guess here but you probably retained too much magnesium with coffee usage. Your body tried to reduce adrenaline signaling because you had caffeine floating around. Now you are dumping the magnesium but potassium is leaving with it so progesterone rises and estrogen falls during a...

Cold hands and feet are from low cortisol not high LOL. People on Ray Peat forum are totally wrong about this. You see there are 2 cases here. Either potassium is high but you are missing NADPH and progesterone cant be converted to cortisol so you run on adrenaline only. In that case we feed...

beware of pickup artists sprinkling salt on their head before going out

@Helen can you give your input on the following context? Fast oxidizer in respiratory alkalosis because of high adrenaline. Cortisol is low. I pee out any b2 I take within 30 minutes. Stomach acid is low (low hydrogen because of alkalosis). Hydrogen water makes me feel good briefly but anything...