Zadig777 Log(PSSD )

zadig777

Well-Known Member
Messages
161
only on pssd forum. mental benefits, not much on libido. will be cycling instead of continiously raising dose.
might try combinations if this doesnt help, still think it will be part of the solution.
smart thing about the cycling great job nice idea very nice

cycling a 5ht1a antagonists like metergoline would be even better i think

whats ur cycling regime?
 

Jaxx

Well-Known Member
Messages
683
raised 0,125mg every other day till 0,5 then slowing down to zero, weeks rest.
5ht1a antagonists have been discussed a long time on the PSSD forum, not with great results. I might consider something that lowers serotonine overall as augmentation however.
cycling progesterone, ella, licorice root etc in parallel is also on the table, but i try to keep it clean for now..
 

zadig777

Well-Known Member
Messages
161
what would lower serotonin?
do u plan on using cyproheptadine + prami as it was ur idea in the past when we spoke on pssd forum?

what about ru or ella,how would it help pssd in short explanation?

tnx jaxx, remember im willing to test anything atm :DD
 

MNK99

Well-Known Member
Messages
5,524
---JUST use TEI. AND the diet, exercise. If need be electrolytes later. IF in horrible health esp. mentally, water fast first. THEN TEI.
--right now you're getting an ADHD answer from someone who was barely an adult when it happened.

--Deleting.
-Wrote long answer.
-Basically, didn't exactly know what to focus on and didn't have the vocab I do now, bc I was partially lobotomized by Effexor and I was 19 or 20. ended 21. Fixed 23 or later.
-Basically: was an addict, untreated manic depressive (not so bad, can be severe less often), untreated ADHD (pretty G'd up regardless), and in a lot of trouble, and pssd, and some other stuff all at once....
---> did use one illegal stimulant, but really... dopamine agonists and NE help sexual drive and more imp for me: FOCUS... so focusing/ just did all those workouts, fasted training, quit alcohol, cut off friends (and actually didn't give a fuck at all), kept my head down, forced work and school, eventually better.
--made school and work and life more possible, but was really self-medication for sure. functional addiction., like alcohol before it but more productive. but was still sad.


-sex drive came back, but relnships and all that were still pretty tough. difficult to trust people and again, learned about ADHD like several yrs later, BPII even after that.
-But knew there was a couple issues. --started by leaving, then getting sober, ditching a bad situation, then just working out walking running lifting (a lot, more than now)...
-Like I worked out 320 + times this year. And couldn't stand till January 25 or so and was refeeding well into late March. i worked out MORE back then.

GLAD mostly worked or did work.
BUT TEI would have been better. esp., at 21 or so, to be able to trust some program? Plus helps render asthma, mood disorder, etc nearly insignificant. (and insomnia comes with the latter). Can't say same about ADHD, but who cares. ADHD is a joke versus PFS or suicidal ideation. Just don't be an engineer, electrician, pilot...

I believe they were both major set backs. I believe I got into Coke bc I didn't have coping mechanisms FOR ANY OF THE STUFF that transpired. ---> but it was also for adhd, plus new friends, self medication. But really, it was for mood too. TEI is better than that. ---hiding a drug addiction while remaking your academic career, finances, etc... and pssd, and avoiding/escaping some shady stuff that happened (also drug related), is pretty fucked up, looking back.

--I strongly believe TEI can cure PFS but 3 or more cycles. I think mood disorder etc too. Also PSSD. --- But the rest has to be there, strong work ethic... sports/gym, clean diet, correct calories, ideally correct sleep regimen also. and focusing on other things/ not only on recovery, seeing friends etc. sounds like bs, but best i can say rite now. PSSD was almost a third of my life ago.

-Took like 2.5 years to see a family doctor 4 years to get on ADD meds, another 3-6months to actually trust the situation enough to titrate them, and 2 more years to try a mood stabilizer. --that's how bad effexor xr was in my case. ---also why I obsessively worked out/ had to do something, also journalled/wrote a ton daily, music, etc too.

-Stims (Some basically 2 and long run 1, the rest are horrible in my experience and all the lives I've seen destroyed with them), work 8/10. Choline 7-8/10. myb more.
-sometimes essential like in law or a phd or some other (grinding work, necessity for some careers).
-BUT TEI actually works better for 4/5 issues. I.e. asthma, mood, insomnia, pfs. not so much adhd, but for the above hypotheticals/ do em when cured or use it then.
-I consider anavar but TEI is healthier.... and does it really actually matter to be 10 or 9% bodyfat versus 13 or 14.... not really.

EDIT: yes it does matter. LEANNESS VASCULARITY HAIR AND SHININESS OVER ALL. PLUS CAREER, MONEY, and TRUE FRIENDSHIP. INTEGRITY, FOCUS, DISCIPLINE, ETC.
AND THE PURSUIT OF A PURE SEXUAL HIGH.
 
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Jaxx

Well-Known Member
Messages
683
what would lower serotonin?
do u plan on using cyproheptadine + prami as it was ur idea in the past when we spoke on pssd forum?

what about ru or ella,how would it help pssd in short explanation?

tnx jaxx, remember im willing to test anything atm :DD
Id say slow down a bit and try licorice root supplement. Will give you more energy and possibly better morning wood. Made me feel better mentally.
Thats a good start to trying more serious stuff and you will survive until new year :)
 

Jaxx

Well-Known Member
Messages
683
Ella/RU work on the progesterone receptor. Which seems to be involved too. Ella is OTC in many countries and safe.
Trying to find a link on the lowering serotonine part
 

Jaxx

Well-Known Member
Messages
683
what would lower serotonin?
do u plan on using cyproheptadine + prami as it was ur idea in the past when we spoke on pssd forum?

what about ru or ella,how would it help pssd in short explanation?

tnx jaxx, remember im willing to test anything atm :DD
Cypro is quite nasty, so im trying to avoid that. Jury isnt out of Tianeptine is a proper SSRE.
@Area-1255 had a nice overview of herbs to decrease serotonin, but its kinda hard to find atm
 
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MNK99

Well-Known Member
Messages
5,524
Honestly, Both were hellish. PFS destroyed me quicker and more severely. And TEI is great for that. SO IF I knew what I was doing... quicker, I'd water fast and TEI back then.
Training was always there, as was clean diet, and discipline (kind of mandatory given background). I should have not been manipulated into psychiatry, and just water fasted. Clearly wrong diagnosis, clearly worst med for mania, and ADHD too (maybe effexor has helped some with ADD, but surely they're not hyperactives).

TEI and water fast. I'm above 80-90% I think for PFS. Maybe RU and ella got me like 5-10%. Maybe they turned something back on. Water fasting got me most gains, then electrolytes (and all the fitness stuff), then randro and 4andro (and again all the fitness, diet stuff). TEI, finishing touches. BUT if I could have skipped A LOT of uncertainty, I think I'd be happier in Feb To like July. And ahead in other goals, instead of rushing to do them, year end (lots of unexpected things occurred, and still worked on them).

I am certain tei and water fast can get 80-95% as long as training and all that stuff is there too. Both PSSD (and mania) and PFS were bad enough that I moved thousands of km, and was in bed depressed. Not knowing what the hell is going on, at prime of life... was pretty bad. But for me sexual probs aside/ still addictive nature, even in pfs crash got laid a couple times painfully, and still had to work hard to run Nofap. Major shrinkage pretty hard to ignore tho, but I did most this year. Probably not so good at that until fasting tho. I don't think there was shrinkage or it was minor with PSSD. Probably rotation on axis tho and definitely hot/cold insensitivity. For each case for me, *mental* sides were the worst aspect. High sex drive and feeling like a different person/ extremely depressed... is not optimal. Balancing, actually makes a lot of sense... Even in good health... life's stressful. TEI works better for me than any shyt like seroquel (what, gain 40lb? GPA goes from A- to not applicable???), or Lamictal (lose 40000 hairs in days).

MANIA from Effexor 10/10 severe. PSSD relative 7-8/10. PFS and depression 11/10.
10/10 = near death exp. I don't think in the absence of shady people around me, Mania/Depression cycles would kill me, but ... it's dangerous anyways and was bad then.
If you're crazy, and outgoing and you attract other crazy people, and you want money fast................. lots of bad things can occur. Better to be alone, honestly sometimes.

Holy SHyt, thanks for bringing up good times @zadig777. :) Haha, just kidding.

#32

--Again, just to be concise and clear; Fix PSSD in 2.5-3years and dislike life. OR**** fix in one year with TEI. probably 1.75 or less years for me. But worked out, and did cardio like a super soldier. ---add time to quit bad habits tho. I must have literally ran away from 500 girls 20-24 that liked me. Acted like a fool. Some of that's shyness, ADD, Hypomania, and also no time. More before that too, but was a doofus before that.
 
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Jaxx

Well-Known Member
Messages
683
Neonatal citalopram exposure produces lasting changes in behavior which are reversed by adult imipramine treatment. - PubMed - NCBI


As I said SSRI probably causes upregulation of MAO, and also breaking down of dopamine in the brain , and noradrenaline is not working.


I am not pro drugs, I d rather use chelators or hormones in this case, than go on some other reuptake inhibitors)) But this is just to show that noradrenaline plays a major part here.

The article is rather weak in the sense that they only look at the effect while ON imipramine, and offer no real explanation why the effect occured.(Only in a 2006 article on citalopram, not why it PARTLY reverses).
 

zadig777

Well-Known Member
Messages
161
Honestly, Both were hellish. PFS destroyed me quicker and more severely. And TEI is great for that. SO IF I knew what I was doing... quicker, I'd water fast and TEI back then.
Training was always there, as was clean diet, and discipline (kind of mandatory given background). I should have not been manipulated into psychiatry, and just water fasted. Clearly wrong diagnosis, clearly worst med for mania, and ADHD too (maybe effexor has helped some with ADD, but surely they're not hyperactives).

TEI and water fast. I'm above 80-90% I think for PFS. Maybe RU and ella got me like 5-10%. Maybe they turned something back on. Water fasting got me most gains, then electrolytes (and all the fitness stuff), then randro and 4andro (and again all the fitness, diet stuff). TEI, finishing touches. BUT if I could have skipped A LOT of uncertainty, I think I'd be happier in Feb To like July. And ahead in other goals, instead of rushing to do them, year end (lots of unexpected things occurred, and still worked on them).

I am certain tei and water fast can get 80-95% as long as training and all that stuff is there too. Both PSSD (and mania) and PFS were bad enough that I moved thousands of km, and was in bed depressed. Not knowing what the hell is going on, at prime of life... was pretty bad. But for me sexual probs aside/ still addictive nature, even in pfs crash got laid a couple times painfully, and still had to work hard to run Nofap. Major shrinkage pretty hard to ignore tho, but I did most this year. Probably not so good at that until fasting tho. I don't think there was shrinkage or it was minor with PSSD. Probably rotation on axis tho and definitely hot/cold insensitivity. For each case for me, *mental* sides were the worst aspect. High sex drive and feeling like a different person/ extremely depressed... is not optimal. Balancing, actually makes a lot of sense... Even in good health... life's stressful. TEI works better for me than any shyt like seroquel (what, gain 40lb? GPA goes from A- to not applicable???), or Lamictal (lose 40000 hairs in days).

MANIA from Effexor 10/10 severe. PSSD relative 7-8/10. PFS and depression 11/10.
10/10 = near death exp. I don't think in the absence of shady people around me, Mania/Depression cycles would kill me, but ... it's dangerous anyways and was bad then.
If you're crazy, and outgoing and you attract other crazy people, and you want money fast................. lots of bad things can occur. Better to be alone, honestly sometimes.

Holy SHyt, thanks for bringing up good times @zadig777. :) Haha, just kidding.

hahah this must be the best user at the forum
skol! hahah
 

Jaxx

Well-Known Member
Messages
683
@zadig777 so going to try imipramine then? Im still reading about it to understand it better and check similar profiles why this would work while others failed
 

zadig777

Well-Known Member
Messages
161
@zadig777 so going to try imipramine then? Im still reading about it to understand it better and check similar profiles why this would work while others failed
im willing to try it yes
i have used TCA's before
that amitryplitine and doxepin
both fucked my errection and ejaculation

im willing to try imipramine cause although its a TCA its used for retrograde ejaculation which we all have

my plan is to try every single dopamine agonist out there before i try imipramine cause imipramine might fuck me up further
i saw a post on pssd forum where some user named Gonzo had success with bromocriptin

honestly the most realistic idea would be cycling different DA till we find the right one
ur on the right track although pramipexole might not be the best joice so u have to jump on other DA


regarding imipramine i judge its not safe to use as first line treatment for shure
Im willing to use pseudoephedrine before imipramine cause its also used for retrograde ejaculation and increases norephinephrine in the body
 

Jaxx

Well-Known Member
Messages
683
im willing to try it yes
i have used TCA's before
that amitryplitine and doxepin
both fucked my errection and ejaculation

im willing to try imipramine cause although its a TCA its used for retrograde ejaculation which we all have

my plan is to try every single dopamine agonist out there before i try imipramine cause imipramine might fuck me up further
i saw a post on pssd forum where some user named Gonzo had success with bromocriptin

honestly the most realistic idea would be cycling different DA till we find the right one
ur on the right track although pramipexole might not be the best joice so u have to jump on other DA


regarding imipramine i judge its not safe to use as first line treatment for shure
Im willing to use pseudoephedrine before imipramine cause its also used for retrograde ejaculation and increases norephinephrine in the body
You are one of the few with retrogade ejaculation, which makes me wonder if you are standard pssd in the first place.
Yes tca’s cause sexual side effects, most of them at least. Its about receptor profile in this case, not about a group. Im all for trying things, but slow and steady. Not full blown and short term, thats also not what they did in the article.

Prami had a broad receptor profile so i dont want to switch just yet, especially since it is known to take up to 3 months to work
 

zadig777

Well-Known Member
Messages
161
im also planning on using reboxetine which is NRI targeting more the norephinephrine aspect of pssd
 

zadig777

Well-Known Member
Messages
161
just popped 10 mg tamoxifen for gaining my balls back?
anyone has any idea how to continue dosing this
i know tamoxifen and clomid bring testicles back so i decided to take it
is it taken once weekly and at what dosage?

regards
 

Pedro melo

Well-Known Member
Messages
430
Ive used tamoxifen for my gino. Didn't work tho. I was taking 10 mg 2x a day... Who said that is bringing your balls back lol?
 

bruschi11

Administrator
Staff member
Messages
2,841
anyone with tamoxifen protocol dosage and frequency?
@bruschi11 u have knowledge from solve
any suggestions?

No idea. Not something I’ve worked with and don’t know why I’m being questioned for it smh.